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ES8500256A1 - Un procedimiento para preparar s-2-acetil-7-2,3-epoxipropoxi benzofurano. - Google Patents

Un procedimiento para preparar s-2-acetil-7-2,3-epoxipropoxi benzofurano.

Info

Publication number
ES8500256A1
ES8500256A1 ES520595A ES520595A ES8500256A1 ES 8500256 A1 ES8500256 A1 ES 8500256A1 ES 520595 A ES520595 A ES 520595A ES 520595 A ES520595 A ES 520595A ES 8500256 A1 ES8500256 A1 ES 8500256A1
Authority
ES
Spain
Prior art keywords
benzofuran
acetyl
isopropylaminopropoxy
hydroxy
salts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES520595A
Other languages
English (en)
Other versions
ES520595A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kaken Pharmaceutical Co Ltd
Original Assignee
Kaken Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kaken Pharmaceutical Co Ltd filed Critical Kaken Pharmaceutical Co Ltd
Publication of ES8500256A1 publication Critical patent/ES8500256A1/es
Publication of ES520595A0 publication Critical patent/ES520595A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D301/00—Preparation of oxiranes
    • C07D301/02—Synthesis of the oxirane ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/86—Benzo [b] furans; Hydrogenated benzo [b] furans with an oxygen atom directly attached in position 7

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE S-2-ACETIL-7-(2-HIDROXI-3-ISOPROPILAMINOPROPOXI)BENZOFURANO Y DE SUS SALES FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I).CONSISTE EN LA REACCION DE CONDENSACION CON DESHIDRATACION Y OXIDACION-REDUCCION DEL 2-ACETIL-7-HIDROXIBENZOFURANO Y R-GLICIDOL, EN UN DISOLVENTE INERTE, EN PRESENCIA DE TRIFENILFOSFINA Y DE UN AZODICARBOXILATO DE DIALCOHILO SEGUIDA DE LA REACCION DEL PRODUCTO FORMADO CON ISOPROPILAMINA.ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE ENFERMEDADES CARDIACAS Y DE GLAUCOMA.
ES520595A 1982-03-16 1983-03-15 Un procedimiento para preparar s-2-acetil-7-2,3-epoxipropoxi benzofurano. Granted ES520595A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP57042145A JPS58157784A (ja) 1982-03-16 1982-03-16 光学活性な〔ｓ〕−（＋）−２−アセチル−７−（２，３−エポキシプロポキシ）ベンゾフランの製造法

Publications (2)

Publication Number Publication Date
ES8500256A1 true ES8500256A1 (es) 1984-10-01
ES520595A0 ES520595A0 (es) 1984-10-01

Family

ID=12627767

Family Applications (1)

Application Number Title Priority Date Filing Date
ES520595A Granted ES520595A0 (es) 1982-03-16 1983-03-15 Un procedimiento para preparar s-2-acetil-7-2,3-epoxipropoxi benzofurano.

Country Status (6)

Country Link
US (1) US4515977A (es)
EP (1) EP0089037B1 (es)
JP (1) JPS58157784A (es)
CA (1) CA1190238A (es)
DE (1) DE3365967D1 (es)
ES (1) ES520595A0 (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2065278A1 (es) * 1993-06-24 1995-02-01 Medichem Sa Procedimiento de obtencion enantioselectivo del levobunolol.

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5629345A (en) * 1993-07-23 1997-05-13 Vide Pharmaceuticals Methods and compositions for ATP-sensitive K+ channel inhibition for lowering intraocular pressure
US5965620A (en) * 1993-07-23 1999-10-12 Vide Pharmaceuticals Methods and compositions for ATP-sensitive K+ channel inhibition for lowering intraocular pressure
US7964613B2 (en) 2007-02-28 2011-06-21 Asahi Kasei Pharma Corporation Sulfonamide compound
JP5650211B2 (ja) * 2009-06-30 2015-01-07 ビーエーエスエフ ソシエタス・ヨーロピアＢａｓｆ Ｓｅ ホスフィンが初期装入される超分岐ポリオールの製造方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA989411A (en) * 1971-05-13 1976-05-18 Kakenyaku Kako Co. Benzofuran derivatives and preparation thereof
JPS5719110B2 (es) * 1972-08-30 1982-04-20

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2065278A1 (es) * 1993-06-24 1995-02-01 Medichem Sa Procedimiento de obtencion enantioselectivo del levobunolol.

Also Published As

Publication number Publication date
JPS58157784A (ja) 1983-09-19
US4515977A (en) 1985-05-07
JPS6320434B2 (es) 1988-04-27
DE3365967D1 (en) 1986-10-16
ES520595A0 (es) 1984-10-01
CA1190238A (en) 1985-07-09
EP0089037B1 (en) 1986-09-10
EP0089037A2 (en) 1983-09-21
EP0089037A3 (en) 1984-05-23

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Legal Events

Date Code Title Description
MM4A Patent lapsed

Effective date: 19960506