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ES8308855A1 - Preparation of 4-(3-methyl-2- butenyl)-1,2-diphenyl-3,5- dioxopyrazolidine - Google Patents

Preparation of 4-(3-methyl-2- butenyl)-1,2-diphenyl-3,5- dioxopyrazolidine

Info

Publication number
ES8308855A1
ES8308855A1 ES516902A ES516902A ES8308855A1 ES 8308855 A1 ES8308855 A1 ES 8308855A1 ES 516902 A ES516902 A ES 516902A ES 516902 A ES516902 A ES 516902A ES 8308855 A1 ES8308855 A1 ES 8308855A1
Authority
ES
Spain
Prior art keywords
dioxopyrazolidine
diphenyl
methyl
butenyl
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES516902A
Other languages
Spanish (es)
Other versions
ES516902A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Instituto de Angeli SpA
Original Assignee
Instituto de Angeli SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Instituto de Angeli SpA filed Critical Instituto de Angeli SpA
Publication of ES8308855A1 publication Critical patent/ES8308855A1/en
Publication of ES516902A0 publication Critical patent/ES516902A0/en
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C07D233/74—Two oxygen atoms, e.g. hydantoin with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to other ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/28—Two oxygen or sulfur atoms
    • C07D231/30—Two oxygen or sulfur atoms attached in positions 3 and 5
    • C07D231/32—Oxygen atoms
    • C07D231/34—Oxygen atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

4-(3-Methyl-2-butenyl)-1,2- diphenyl-3,5-dioxopyrazolidine (Feprazone) is prepared by reacting 3- methyl-2-butenyl acetate with an alkali metal salt of 1,2-diphenyl-3,5- dioxopyrazolidine in the presence of a catalyst, preferably a palladium complex, and a ligand.
ES516902A 1981-10-29 1982-10-28 A PROCEDURE FOR THE PREPARATION OF 4- (3-METHYL-2-BUTENYL) -1,2-DIPHENYL-3,5-DIOXOPYRAZOLIDINE. Granted ES516902A0 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT24772/81A IT1168184B (en) 1981-10-29 1981-10-29 PROCESS FOR THE PREPARATION OF 4- (3-METHYL-2-BUTANYL) -1,2-DIPHENYL-3,5 DICHETOPYRAZOLIDINE

Publications (2)

Publication Number Publication Date
ES8308855A1 true ES8308855A1 (en) 1983-10-01
ES516902A0 ES516902A0 (en) 1983-10-01

Family

ID=11214682

Family Applications (1)

Application Number Title Priority Date Filing Date
ES516902A Granted ES516902A0 (en) 1981-10-29 1982-10-28 A PROCEDURE FOR THE PREPARATION OF 4- (3-METHYL-2-BUTENYL) -1,2-DIPHENYL-3,5-DIOXOPYRAZOLIDINE.

Country Status (19)

Country Link
JP (1) JPS5888365A (en)
KR (1) KR840001955A (en)
AR (1) AR231832A1 (en)
AT (1) AT379151B (en)
CA (1) CA1179354A (en)
CH (1) CH651555A5 (en)
DK (1) DK477882A (en)
ES (1) ES516902A0 (en)
FI (1) FI823545L (en)
FR (1) FR2515646B1 (en)
GB (1) GB2108125B (en)
GR (1) GR77724B (en)
IT (1) IT1168184B (en)
NL (1) NL8204170A (en)
NO (1) NO823596L (en)
PH (1) PH19644A (en)
PT (1) PT75755B (en)
SE (1) SE8206143L (en)
YU (1) YU240282A (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107778247A (en) * 2016-08-30 2018-03-09 天津太平洋制药有限公司 A kind of preparation method of feprazone and its intermediate

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1301857A (en) * 1969-06-27 1973-01-04

Also Published As

Publication number Publication date
NL8204170A (en) 1983-05-16
FR2515646A1 (en) 1983-05-06
NO823596L (en) 1983-05-02
YU240282A (en) 1985-03-20
GR77724B (en) 1984-09-25
GB2108125B (en) 1985-03-20
FI823545L (en) 1983-04-30
PT75755A (en) 1982-11-01
CA1179354A (en) 1984-12-11
DK477882A (en) 1983-04-30
AT379151B (en) 1985-11-25
AR231832A1 (en) 1985-03-29
JPS5888365A (en) 1983-05-26
FR2515646B1 (en) 1986-02-14
CH651555A5 (en) 1985-09-30
SE8206143D0 (en) 1982-10-28
FI823545A0 (en) 1982-10-18
ES516902A0 (en) 1983-10-01
SE8206143L (en) 1983-04-30
PH19644A (en) 1986-06-04
KR840001955A (en) 1984-06-07
PT75755B (en) 1985-11-20
ATA370382A (en) 1985-04-15
GB2108125A (en) 1983-05-11
IT8124772A0 (en) 1981-10-29
IT1168184B (en) 1987-05-20

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