[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

ES8308571A1 - Inclusion complexes of steroids with delta -cyclodextrin - Google Patents

Inclusion complexes of steroids with delta -cyclodextrin

Info

Publication number
ES8308571A1
ES8308571A1 ES516840A ES516840A ES8308571A1 ES 8308571 A1 ES8308571 A1 ES 8308571A1 ES 516840 A ES516840 A ES 516840A ES 516840 A ES516840 A ES 516840A ES 8308571 A1 ES8308571 A1 ES 8308571A1
Authority
ES
Spain
Prior art keywords
cyclodextrin
steroids
delta
reichstein
complexes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES516840A
Other languages
Spanish (es)
Other versions
ES516840A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Richter Gedeon Vegyeszeti Gyar Nyrt
Original Assignee
Richter Gedeon Vegyeszeti Gyar RT
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszeti Gyar RT filed Critical Richter Gedeon Vegyeszeti Gyar RT
Publication of ES8308571A1 publication Critical patent/ES8308571A1/en
Publication of ES516840A0 publication Critical patent/ES516840A0/en
Granted legal-status Critical Current

Links

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J21/00Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/001Lactones
    • C07J21/003Lactones at position 17
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J5/00Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Nanotechnology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The title complexes have 3-100 times the water-solubility of the uncomplexed steroids, e.g. spironolactone, nortestosterone, methyltestosterone, androst-4-ene- 3,17-dione, progesterone, Reichstein S, Reichstein S aceate, 16-methyl- Reichstein S, Hydrocortisone, estrone, dexamethasone, prednisolone, triamcinolone, pregnenetriolone triacetate. Pharmaceutical compositions containing the title complexes are free from the nephrotoxic effects of the corresponding alpha - and beta -cyclodextrin complexes owing to the faster enzymatic decomposition of delta -cyclodextrin.
ES516840A 1981-10-27 1982-10-26 PROCEDURE TO PREPARE INCLUSION COMPLEXES OF POORLY SOLUBLE STEROIDS IN WATER WITH -CYCLODEXTRIN. Granted ES516840A0 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU813147A HU190356B (en) 1981-10-27 1981-10-27 Process for preparing steroid-gamma-cyclodextrin inclusion complexes with high water-solubility

Publications (2)

Publication Number Publication Date
ES8308571A1 true ES8308571A1 (en) 1983-09-16
ES516840A0 ES516840A0 (en) 1983-09-16

Family

ID=10962794

Family Applications (1)

Application Number Title Priority Date Filing Date
ES516840A Granted ES516840A0 (en) 1981-10-27 1982-10-26 PROCEDURE TO PREPARE INCLUSION COMPLEXES OF POORLY SOLUBLE STEROIDS IN WATER WITH -CYCLODEXTRIN.

Country Status (12)

Country Link
JP (1) JPS5883699A (en)
BE (1) BE894825A (en)
DD (1) DD208549A5 (en)
DE (1) DE3238800A1 (en)
DK (1) DK474782A (en)
ES (1) ES516840A0 (en)
FR (1) FR2515187A1 (en)
GB (1) GB2109381A (en)
HU (1) HU190356B (en)
IT (1) IT1191049B (en)
NL (1) NL8204122A (en)
SE (1) SE8206055L (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU196230B (en) * 1983-12-29 1988-10-28 Chinoin Gyogyszer Es Vegyeszet Process for producing water-soluble forms of polyene antibiotics and pharmaceutics comprising such active ingredient and plant protective with antifungal effect
GB2162529B (en) * 1984-06-08 1988-03-02 Nitrokemia Ipartelepek B-cyclodextrin complex of benzene sulphonyl urea derivatives
US5223295A (en) * 1988-01-22 1993-06-29 Asterol International Process for the elimination of steroid compounds contained in substance of biological origin
WO1990001320A1 (en) * 1988-08-15 1990-02-22 American Maize-Products Company Water soluble branched beta cyclodextrin steroid complex
US5229370A (en) * 1988-08-15 1993-07-20 Ammeraal Robert N Water soluble branched beta cyclodextrin steroid complex
WO1992020699A1 (en) * 1991-05-20 1992-11-26 Eisai Co., Ltd. Steroid compound combined with polysaccharide
US20040152664A1 (en) * 1998-09-02 2004-08-05 Allergan, Inc. Prednisolone compositions
ES2269504T3 (en) * 2000-11-02 2007-04-01 Akzo Nobel N.V. USE OF COMPLEXING AGENTS WITH CORTISOL IN TABLES OF TREATMENT OF DISORDERS RELATED TO HYPERCORTISOLEMIA.
EP1216712A1 (en) 2000-12-20 2002-06-26 Schering Aktiengesellschaft Cyclodextrin-drospirenone inclusion complexes
EP1216713A1 (en) 2000-12-20 2002-06-26 Schering Aktiengesellschaft Compositions of estrogen-cyclodextrin complexes
EP1353699B1 (en) * 2000-12-20 2012-02-01 Bayer Pharma Aktiengesellschaft Beta-cyclodextrin-drospirenone inclusion complexes
US20070020298A1 (en) * 2003-12-31 2007-01-25 Pipkin James D Inhalant formulation containing sulfoalkyl ether gamma-cyclodextrin and corticosteroid
US20070020299A1 (en) * 2003-12-31 2007-01-25 Pipkin James D Inhalant formulation containing sulfoalkyl ether cyclodextrin and corticosteroid
WO2013135248A2 (en) * 2012-03-13 2013-09-19 Amphidex A/S Production of stabilized channel type cyclodextrin crystals

Also Published As

Publication number Publication date
NL8204122A (en) 1983-05-16
DK474782A (en) 1983-04-28
IT1191049B (en) 1988-02-24
FR2515187A1 (en) 1983-04-29
DD208549A5 (en) 1984-04-04
DE3238800A1 (en) 1983-05-05
SE8206055D0 (en) 1982-10-25
HU190356B (en) 1986-08-28
ES516840A0 (en) 1983-09-16
JPS5883699A (en) 1983-05-19
GB2109381A (en) 1983-06-02
BE894825A (en) 1983-02-14
SE8206055L (en) 1983-04-28
IT8223942A0 (en) 1982-10-26

Similar Documents

Publication Publication Date Title
ES8308571A1 (en) Inclusion complexes of steroids with delta -cyclodextrin
DE10199030I1 (en) Substituted androsta-1, 4-diene-3, 17-diones and process for their preparation
KR950016715A (en) Sugar-Type Pharmaceutical Dosage Units
GB1092145A (en) Microbiological conversion of steroids
GB1291205A (en) A novel pregnane derivative, processes for its preparation, and compositions incorporating it
Kime Steroid biosynthesis by the testes of the dogfish Scyliorhinus caniculus
GB1208078A (en) Process for the microbiological degradation of the 17-side chain of steroids
JPS5798300A (en) Manufacture of pregnane derivative
CA1028952A (en) Method of preparing sterol and steroid glycoside compositions
GB1328998A (en) Process of corticosteroids
GB1495531A (en) 11beta-alkyl steroids of the estrane series
CA2096020A1 (en) 2.beta.,19-methyleneamino bridged steroids as aromatase inhibitors
ES363997A1 (en) 3-silyl-ether steroids
IL51370A (en) Microbiological process for preparing a mixture of androsta-1,4-diene-3,17-dione and androst-4-ene-3,17-dione and novel mycobacterium fortuitum nrrl b-8153
GB1244143A (en) Trialkyl-silyloxy-steroids
CA729157A (en) Process for preparing androst-4-ene-3,17-dione and androsta-1,4-diene-3,17-dione from steroidal compounds by the action of micro-organisms
JPS52136157A (en) Preparation of steroid 17-esters
EP0402963A3 (en) 17-alpha ethynyl steroids
AT272536B (en) Process for the preparation of androsta-1,4-diene-3,17-dione
GB2018257A (en) 11 beta -Silylation in corticoid synthesis
GB1267915A (en) Ring a-substituted ring a-aromatic steroids
GB1009918A (en) Improvements in or relating to 6ªš-lower alkanoylthio-4-en-3-one steroids and their preparation
GB1291036A (en) 7-methyl-7-hydroxy-steroids
GB1008274A (en) Process for the manufacture of steroid-dienes
AU607565C (en) Improvement in the synthesis of 6-methylene derivatives of androsta-1, 4-diene-3,17-dione