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ES8307751A1 - "un procedimiento para la preparacion de derivados de piridinona". - Google Patents

"un procedimiento para la preparacion de derivados de piridinona".

Info

Publication number
ES8307751A1
ES8307751A1 ES510908A ES510908A ES8307751A1 ES 8307751 A1 ES8307751 A1 ES 8307751A1 ES 510908 A ES510908 A ES 510908A ES 510908 A ES510908 A ES 510908A ES 8307751 A1 ES8307751 A1 ES 8307751A1
Authority
ES
Spain
Prior art keywords
amino
cardiotonics
sec
hydrogen
carbamyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES510908A
Other languages
English (en)
Other versions
ES510908A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
STWB Inc
Original Assignee
Sterling Drug Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sterling Drug Inc filed Critical Sterling Drug Inc
Publication of ES510908A0 publication Critical patent/ES510908A0/es
Publication of ES8307751A1 publication Critical patent/ES8307751A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/73—Unsubstituted amino or imino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/84—Nitriles
    • C07D213/85—Nitriles in position 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)

Abstract

UN PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE PIRIDINONA. SE HACE REACCIONAR UNA 1,2-DIHIDRO-2-OXO-5(3-R -4-R -FENIL)-6-R-NICOTINAMIDA O UN COMPUESTO DE ESTA NATURALEZA, CON UN REACTIVO CAPAZ DE CONVERTIR EL CARBAMILO A AMINO. EN EL CASO DE OBTENERSE UN COMPUESTO (I) DONDE R Y/O R SON ALCOXI INFERIOR Y/O NITRO, SE PUEDE HACER REACCIONAR DICHO COMPUESTO PARA TRANSFORMAR DE ALCOXI INFERIOR A HIDROXI O BIEN EL NITRO A AMINO. ASI MISMO PUEDE TRANSFORMARSE UNA BASE LIBRE OBTENIDA EN LA SAL DE ADICION DE ACIDO CORRESPONDIENTE. ACTIVIDAD CARDIOTONICA.
ES510908A 1981-03-30 1982-03-29 "un procedimiento para la preparacion de derivados de piridinona". Expired ES8307751A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24884081A 1981-03-30 1981-03-30
US30029481A 1981-09-08 1981-09-08

Publications (2)

Publication Number Publication Date
ES510908A0 ES510908A0 (es) 1983-07-01
ES8307751A1 true ES8307751A1 (es) 1983-07-01

Family

ID=26939613

Family Applications (1)

Application Number Title Priority Date Filing Date
ES510908A Expired ES8307751A1 (es) 1981-03-30 1982-03-29 "un procedimiento para la preparacion de derivados de piridinona".

Country Status (8)

Country Link
EP (1) EP0061774A3 (es)
AU (1) AU8211482A (es)
DK (1) DK142382A (es)
ES (1) ES8307751A1 (es)
FI (1) FI821092L (es)
IL (1) IL65278A0 (es)
NO (1) NO821046L (es)
PT (1) PT74664B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4559352A (en) * 1981-03-30 1985-12-17 Sterling Drug Inc. 1,2-Dihydro-2-oxo-5-(hydroxy-and/or amino-phenyl)-nicotinonitriles and cardiotonic use thereof
US4524149A (en) * 1982-03-15 1985-06-18 Sterling Drug Inc. 5-Alkanoyl-6-alkyl-2(1H)-pyridinones, their preparation and their cardiotonic use
FR2527206B1 (fr) * 1982-05-18 1986-12-05 Sandoz Sa Nouveaux derives de la 2(1h)-pyridinone, leur preparation et leur utilisation comme medicaments
IL69407A (en) * 1982-08-23 1987-10-20 Warner Lambert Co 2(1h)-pyridinones,their preparation and pharmaceutical compositions containing them
US4769380A (en) * 1983-04-29 1988-09-06 Merrell Dow Pharmaceuticals Inc. Cardiotonic 5-benzoyl-1,2-dihydro-2-oxo-3-pyridinecarboxylates
US5212314A (en) * 1983-11-03 1993-05-18 Merrell Dow Pharmaceuticals Inc. Alkoxyimino ether derivatives of 5-acyl-2(1H)-pyridinones
US4732982A (en) * 1983-11-03 1988-03-22 Merrell Dow Pharmaceuticals Inc. Novel alkoxyimino ether derivatives of 5-acyl-2(1H)-pyridinones
ATE77817T1 (de) 1985-04-30 1992-07-15 Dresden Arzneimittel 3-cyan-pyridine, verfahren zu ihrer herstellung und ihre pharmazeutische verwendung.
US5308854A (en) * 1990-06-18 1994-05-03 Merck & Co., Inc. Inhibitors of HIV reverse transcriptase

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3718743A (en) * 1970-11-19 1973-02-27 Merck & Co Inc 5-phenyl-2-piperidones and 5-phenyl-2-thiopiperidones in compositions and methods for treating pain, fever and inflammation
US4072746A (en) * 1975-10-14 1978-02-07 Sterling Drug Inc. 3-Amino-5-(pyridinyl)-2(1H)-pyridinones
DE3106460A1 (de) * 1980-03-03 1982-01-28 Sandoz-Patent-GmbH, 7850 Lörrach 2(1h)-pyridinon-derivate, ihre herstellung und sie enthaltende pharmazeutische zubereitungen

Also Published As

Publication number Publication date
ES510908A0 (es) 1983-07-01
PT74664B (en) 1983-11-08
FI821092L (fi) 1982-10-01
NO821046L (no) 1982-10-01
AU8211482A (en) 1982-10-07
DK142382A (da) 1982-10-01
PT74664A (en) 1982-04-01
EP0061774A3 (en) 1983-09-07
EP0061774A2 (en) 1982-10-06
FI821092A0 (fi) 1982-03-29
IL65278A0 (en) 1982-05-31

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