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ES8307258A1 - "procedimiento para la preparacion de nuevas cefalosporinas". - Google Patents

"procedimiento para la preparacion de nuevas cefalosporinas".

Info

Publication number
ES8307258A1
ES8307258A1 ES509555A ES509555A ES8307258A1 ES 8307258 A1 ES8307258 A1 ES 8307258A1 ES 509555 A ES509555 A ES 509555A ES 509555 A ES509555 A ES 509555A ES 8307258 A1 ES8307258 A1 ES 8307258A1
Authority
ES
Spain
Prior art keywords
cephalosporins
compounds
processes
preparation
pharmaceutical compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES509555A
Other languages
English (en)
Other versions
ES509555A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BESCHRANKTER HAFTUNG
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
BESCHRANKTER HAFTUNG
Dr Karl Thomae GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BESCHRANKTER HAFTUNG, Dr Karl Thomae GmbH filed Critical BESCHRANKTER HAFTUNG
Publication of ES509555A0 publication Critical patent/ES509555A0/es
Publication of ES8307258A1 publication Critical patent/ES8307258A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/587—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with aliphatic hydrocarbon radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms, said aliphatic radicals being substituted in the alpha-position to the ring by a hetero atom, e.g. with m >= 0, Z being a singly or a doubly bound hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • External Artificial Organs (AREA)
  • Bidet-Like Cleaning Device And Other Flush Toilet Accessories (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Peptides Or Proteins (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE NUEVAS CEFALOSPORINAS. SE HACE REACCIONAR UN COMPUESTO (I) EN EL QUE EN LUGAR DE OCH SE ENCUENTRA UN ATOMO DE HIDROGENO, EN PRESENCIA DE METANOL, CON UN METILATO DE UN METOL ALCALINO M>+OCH Y DESPUES SE HACE REACCIONAR CON UN AGENTE DE HALOGENACION EN UN DISOLVENTE INERTE A TEMPERATURAS COMPRENDIDAS ENTRE -120 Y -10 C. OPCIONALMENTE, EL COMPUESTO OBTENIDO (I) EN QUE E ES UN GRUPO PROTECTOR SEPARABLE ~AIN VITRO~B O ~AIN VIVO~B SE TRANSFORMA EN EL ACIDO CARBOXILICO LIBRE CORRESPONDIENTE. UNA VEZ TERMINADA LA HALOGENACION SE INTERRUMPE LA REACCION POR MEDIO DE LA ADICION DE UN ACIDO.
ES509555A 1980-02-29 1982-02-12 "procedimiento para la preparacion de nuevas cefalosporinas". Expired ES8307258A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19803007685 DE3007685A1 (de) 1980-02-29 1980-02-29 Neue cephylosporine, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel

Publications (2)

Publication Number Publication Date
ES509555A0 ES509555A0 (es) 1983-06-16
ES8307258A1 true ES8307258A1 (es) 1983-06-16

Family

ID=6095889

Family Applications (4)

Application Number Title Priority Date Filing Date
ES499864A Expired ES8303425A1 (es) 1980-02-29 1981-02-27 Procedimiento para la preparacion de nuevas cefalosporinas
ES509554A Expired ES8307821A1 (es) 1980-02-29 1982-02-12 "procedimiento para la preparacion de nuevas cefalosporinas".
ES509553A Expired ES8307257A1 (es) 1980-02-29 1982-02-12 "procedimiento para la preparacion de nuevas cefalosporinas".
ES509555A Expired ES8307258A1 (es) 1980-02-29 1982-02-12 "procedimiento para la preparacion de nuevas cefalosporinas".

Family Applications Before (3)

Application Number Title Priority Date Filing Date
ES499864A Expired ES8303425A1 (es) 1980-02-29 1981-02-27 Procedimiento para la preparacion de nuevas cefalosporinas
ES509554A Expired ES8307821A1 (es) 1980-02-29 1982-02-12 "procedimiento para la preparacion de nuevas cefalosporinas".
ES509553A Expired ES8307257A1 (es) 1980-02-29 1982-02-12 "procedimiento para la preparacion de nuevas cefalosporinas".

Country Status (18)

Country Link
US (1) US4370327A (es)
EP (1) EP0035161B1 (es)
JP (1) JPS56135491A (es)
AT (1) ATE5408T1 (es)
AU (1) AU541190B2 (es)
CA (1) CA1150726A (es)
DE (2) DE3007685A1 (es)
DK (1) DK87281A (es)
ES (4) ES8303425A1 (es)
FI (1) FI810618L (es)
GR (1) GR73684B (es)
HU (1) HU184390B (es)
IL (1) IL62226A (es)
NO (1) NO810678L (es)
NZ (1) NZ196370A (es)
PH (1) PH17062A (es)
PT (1) PT72582B (es)
ZA (1) ZA811316B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3038501A1 (de) * 1980-10-11 1982-05-19 Dr. Karl Thomae Gmbh, 7950 Biberach Neue cephalosporine, verfahren zu ihrer herstellung und diese verbindung enthaltende arzneimittel
EP0053276A3 (de) * 1980-12-02 1983-08-03 Dr. Karl Thomae GmbH Neue Cephalosporine, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
DE3047082A1 (de) * 1980-12-13 1982-07-29 Dr. Karl Thomae Gmbh, 7950 Biberach Neue cephalosporine, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
JPS5874680A (ja) * 1981-10-01 1983-05-06 Kyowa Hakko Kogyo Co Ltd β−ラクタム化合物
US4758557A (en) * 1985-06-26 1988-07-19 Meiji Seika Kaisha, Ltd. Cephalosporin derivatives and bactericides containing the same

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK154939C (da) 1974-12-19 1989-06-12 Takeda Chemical Industries Ltd Analogifremgangsmaade til fremstilling af thiazolylacetamido-cephemforbindelser eller farmaceutisk acceptable salte eller estere deraf
JPS5919114B2 (ja) * 1975-08-25 1984-05-02 武田薬品工業株式会社 セフアロスポリンの製造法
US4063019A (en) * 1976-03-30 1977-12-13 E. R. Squibb & Sons, Inc. [[[(2,4-Dioxo-1-imidazolidinyl)amino]carbonyl]amino]-acetylcephalosporin derivatives
JPS5344585A (en) * 1976-10-02 1978-04-21 Meiji Seika Kaisha Ltd Cephalosporin derivatives and their preparation
JPS54117494A (en) * 1978-03-03 1979-09-12 Takeda Chem Ind Ltd Cephalosporin compound and its preparation
ZA792724B (en) 1978-06-16 1980-08-27 Squibb & Sons Inc Iminothiazolyl ureido cephalosporins
DE2828261A1 (de) * 1978-06-28 1980-01-10 Thomae Gmbh Dr K Neue penicilline, ihre salze, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
JPS6058239B2 (ja) 1978-07-20 1985-12-19 山之内製薬株式会社 新規セフアロスポリン誘導体
DE2924948A1 (de) * 1979-06-21 1981-01-22 Thomae Gmbh Dr K Neue cephalosporine, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE2928344A1 (de) 1979-07-13 1981-02-05 Thomae Gmbh Dr K Neue lactame, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel

Also Published As

Publication number Publication date
HU184390B (en) 1984-08-28
PT72582B (pt) 1982-10-21
DE3007685A1 (de) 1981-10-01
NO810678L (no) 1981-08-31
DE3161462D1 (en) 1983-12-29
ES509553A0 (es) 1983-06-16
DK87281A (da) 1981-08-30
ZA811316B (en) 1982-11-24
CA1150726A (en) 1983-07-26
ES499864A0 (es) 1983-02-01
EP0035161A2 (de) 1981-09-09
US4370327A (en) 1983-01-25
GR73684B (es) 1984-04-02
PT72582A (pt) 1981-03-01
ES509555A0 (es) 1983-06-16
ES509554A0 (es) 1983-07-16
AU541190B2 (en) 1984-12-20
IL62226A0 (en) 1981-03-31
EP0035161A3 (en) 1981-11-04
AU6792681A (en) 1981-09-03
ES8307821A1 (es) 1983-07-16
ES8303425A1 (es) 1983-02-01
EP0035161B1 (de) 1983-11-23
FI810618L (fi) 1981-08-30
IL62226A (en) 1984-03-30
PH17062A (en) 1984-05-24
ES8307257A1 (es) 1983-06-16
JPS56135491A (en) 1981-10-22
NZ196370A (en) 1984-03-30
ATE5408T1 (de) 1983-12-15

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