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ES8304096A1 - "procedimiento para la preparacion de nuevas piriimidinonas". - Google Patents

"procedimiento para la preparacion de nuevas piriimidinonas".

Info

Publication number
ES8304096A1
ES8304096A1 ES82511835A ES511835A ES8304096A1 ES 8304096 A1 ES8304096 A1 ES 8304096A1 ES 82511835 A ES82511835 A ES 82511835A ES 511835 A ES511835 A ES 511835A ES 8304096 A1 ES8304096 A1 ES 8304096A1
Authority
ES
Spain
Prior art keywords
carbon atoms
hydrogen
alkoxy
alkylene
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES82511835A
Other languages
English (en)
Other versions
ES511835A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Dr Karl Thomae GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19803046871 external-priority patent/DE3046871A1/de
Priority claimed from DE19813115447 external-priority patent/DE3115447A1/de
Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH
Publication of ES511835A0 publication Critical patent/ES511835A0/es
Publication of ES8304096A1 publication Critical patent/ES8304096A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C07D239/91—Oxygen atoms with aryl or aralkyl radicals attached in position 2 or 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/20—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 4
    • C07D265/22—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE PIRIMIDINONAS Y DE SUS SALES, DE FORMULA (I), EN LA QUE D ES ALCOHILENO O HIDROXIALCOHILENO; R Y R SON HIDROGENO O ALCOHILO; R ES HIDROXI O ALCOXI; Y A, B Y R PUEDEN SER VARIOS RADICALES; COMPUESTOS QUE TIENEN APLICACIONES FARMACOLOGICAS POR SU EFECTO HIPOTENSOR, ANTIARRITMICO Y BLOQUEANTE DE ~J-RECEPTORES. CONSISTE EN LA REACCION DE ALCOHILACION DE UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE FORMULA Z-Y, EN LAS QUE Z ES UN GRUPO SUSTITUIBLE NUCLEOFILICAMENTE; Y ES R , R O R ; Y TODOS LOS DEMAS SIMBOLOS TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). LA REACCION SE LLEVA A CABO EN UN DISOLVENTE ORGANICO, A UNA TEMPERATURA ENTRE 0 C Y 180 C.
ES82511835A 1980-12-12 1982-04-30 "procedimiento para la preparacion de nuevas piriimidinonas". Expired ES8304096A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19803046871 DE3046871A1 (de) 1980-12-12 1980-12-12 Neue chinazolinone, ihre herstellung und ihre verwendung als arzneimittel
DE19813115447 DE3115447A1 (de) 1981-04-16 1981-04-16 Neue pyrimidinone, ihre herstellung und ihre verwendung als arzneimittel

Publications (2)

Publication Number Publication Date
ES511835A0 ES511835A0 (es) 1983-02-16
ES8304096A1 true ES8304096A1 (es) 1983-02-16

Family

ID=25789685

Family Applications (2)

Application Number Title Priority Date Filing Date
ES507761A Expired ES8207156A1 (es) 1980-12-12 1981-12-07 Procedimiento para la preparacion de nuevas pirimidinonas .
ES82511835A Expired ES8304096A1 (es) 1980-12-12 1982-04-30 "procedimiento para la preparacion de nuevas piriimidinonas".

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES507761A Expired ES8207156A1 (es) 1980-12-12 1981-12-07 Procedimiento para la preparacion de nuevas pirimidinonas .

Country Status (22)

Country Link
US (1) US4379788A (es)
EP (1) EP0054132B1 (es)
AR (1) AR227567A1 (es)
AU (1) AU543568B2 (es)
CA (1) CA1217767A (es)
CS (1) CS227024B2 (es)
DD (1) DD208151A5 (es)
DE (1) DE3166627D1 (es)
DK (1) DK525481A (es)
ES (2) ES8207156A1 (es)
FI (1) FI813971L (es)
GB (1) GB2090249B (es)
GR (1) GR76952B (es)
HU (1) HU187384B (es)
IL (1) IL64504A (es)
MY (1) MY8700562A (es)
NO (1) NO814239L (es)
NZ (1) NZ199254A (es)
PH (1) PH18930A (es)
PL (1) PL135330B1 (es)
PT (1) PT74116B (es)
SU (1) SU1056900A3 (es)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4460589A (en) * 1980-10-03 1984-07-17 The Upjohn Company Process for treating hypertension
US4379778A (en) * 1980-10-10 1983-04-12 Air Products And Chemicals, Inc. Hydrogen peroxide synthesis
DE3428476A1 (de) * 1984-08-02 1986-02-13 Basf Ag, 6700 Ludwigshafen 4h-pyrido(2,3-d)(1,3)oxazin-4-on-derivate, verfahren zu ihrer herstellung und ihre verwendung zur bekaempfung unerwuenschten pflanzenwuchses
DE3631294A1 (de) * 1986-09-13 1988-03-24 Thomae Gmbh Dr K Neue synergistische kombination bestehend aus einem phosphodiesterase-hemmer und einem thromboxan-a(pfeil abwaerts)2(pfeil abwaerts)-antagonisten und deren verwendung bzw. herstellung
US5037980A (en) * 1988-04-18 1991-08-06 American Cyanamid Company Phenyl imidazo[1,2-a]pyrimidines
GB8928346D0 (en) * 1989-12-15 1990-02-21 Smith Kline French Lab Chemical compounds
GB9126260D0 (en) * 1991-12-11 1992-02-12 Pfizer Ltd Therapeutic agents
GB9404485D0 (en) * 1994-03-09 1994-04-20 Cancer Res Campaign Tech Benzamide analogues
CH693954A5 (de) 1997-11-12 2004-05-14 Bayer Ag 2-Phenyl-substituierte Imidazotriazinone als Phosphodiesterase Inhibitoren.
WO2000029389A1 (fr) * 1998-11-18 2000-05-25 Elena Alexandrovna Izaxon 6-(3-carboxymethylphenyl)-amino-uracyle ayant une action biologique
US20040102324A1 (en) 2002-02-28 2004-05-27 Annis Gary David Heterocyclic diamide invertebrate pest control agents
US6642244B2 (en) 2001-03-16 2003-11-04 Bristol-Myers Squibb Co. Pyrazolopyridopyrimidine inhibitors of cGMP phosphodiesterase
CA2444704C (en) * 2001-04-23 2012-07-10 University Of Virginia Patent Foundation Synthesis and evaluation of phthalimide mimics as anti-angiogenic agents
EP1392314B1 (de) * 2001-05-09 2006-12-20 Bayer HealthCare AG NEUE VERWENDUNG VON 2-[2-Ethoxy-5-(4-methyl-piperazin-1-sulfonyl)-phenyl]-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-on
DE10232113A1 (de) * 2002-07-16 2004-01-29 Bayer Ag Vardenafil Hydrochlorid Trihydrat enthaltende Arzneimittel
US20070060601A1 (en) * 2003-12-19 2007-03-15 Arrington Kenneth L Mitotic kinesin inhibitors
SE0401345D0 (sv) * 2004-05-25 2004-05-25 Astrazeneca Ab Therapeutic compounds: Pyridine as scaffold
SE0401342D0 (sv) * 2004-05-25 2004-05-25 Astrazeneca Ab Therapeutic compounds
CA2569081A1 (en) * 2004-05-31 2005-12-08 Takashi Mizutani Quinazoline derivative
DE102005001989A1 (de) * 2005-01-15 2006-07-20 Bayer Healthcare Ag Intravenöse Formulierungen von PDE-Inhibitoren
DE102005009241A1 (de) * 2005-03-01 2006-09-07 Bayer Healthcare Ag Arzneiformen mit kontrollierter Bioverfügbarkeit
DE102005009240A1 (de) * 2005-03-01 2006-09-07 Bayer Healthcare Ag Arzneiformen mit verbesserten pharmakokinetischen Eigenschaften
WO2007039075A2 (en) * 2005-09-29 2007-04-12 Bayer Healthcare Ag Pde inhibitors and combinations thereof for the treatment of urological disorders
MX2009003673A (es) * 2006-10-04 2009-04-22 Pfizer Prod Inc Derivados de piridido[4,3-d]pirimidin-4(3h)-ona como antagonistas de los receptores de calcio.
US20100184769A1 (en) * 2007-06-13 2010-07-22 Bayer Schering Pharma Aktiengesellschaft Pde inhibitors for the treatment of hearing impairment
CN101531638B (zh) * 2008-03-13 2011-12-28 中国科学院广州生物医药与健康研究院 用作雌激素相关受体调节剂的化合物及其应用
WO2009139834A1 (en) * 2008-05-13 2009-11-19 Poniard Pharmaceuticals, Inc. Bioactive compounds for treatment of cancer and neurodegenerative diseases
CN101628913B (zh) 2008-07-18 2013-01-23 中国科学院广州生物医药与健康研究院 用作雌激素相关受体调节剂的化合物及其应用
AU2013324681B2 (en) * 2012-09-26 2017-08-10 Merck Patent Gmbh Quinazolinone derivatives as PARP inhibitors

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3265697A (en) * 1964-09-04 1966-08-09 Shulton Inc 2-p-dialkylaminoalkoxyphenyl-2, 3-dihydro-4 (1h)-quinazolinones and their derivatives
DE1939109A1 (de) * 1968-08-31 1970-03-05 Troponwerke Dinklage & Co 2-Methyl-3-[2-(2-diaethylaminoaethoxy)-phenyl]-chinazolinon-(4) und Verfahren zu seiner Herstellung
US3862191A (en) * 1972-09-27 1975-01-21 Pfizer Pyrido{8 2,3-d{9 pyrimidin-4(3H)-one

Also Published As

Publication number Publication date
PL135330B1 (en) 1985-10-31
EP0054132B1 (de) 1984-10-10
DD208151A5 (de) 1984-03-28
AU543568B2 (en) 1985-04-26
AU7847381A (en) 1982-06-17
MY8700562A (en) 1987-12-31
ES511835A0 (es) 1983-02-16
GB2090249A (en) 1982-07-07
SU1056900A3 (ru) 1983-11-23
GB2090249B (en) 1984-08-22
DE3166627D1 (en) 1984-11-15
CS227024B2 (en) 1984-04-16
US4379788A (en) 1983-04-12
GR76952B (es) 1984-09-04
PL234175A1 (es) 1982-08-16
IL64504A0 (en) 1982-03-31
DK525481A (da) 1982-06-13
IL64504A (en) 1985-02-28
PH18930A (en) 1985-11-11
PT74116A (de) 1982-01-01
ES507761A0 (es) 1982-09-01
EP0054132A1 (de) 1982-06-23
PT74116B (de) 1983-12-19
NZ199254A (en) 1985-02-28
NO814239L (no) 1982-06-14
AR227567A1 (es) 1982-11-15
ES8207156A1 (es) 1982-09-01
CA1217767A (en) 1987-02-10
FI813971L (fi) 1982-06-13
HU187384B (en) 1985-12-28

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