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ES8205858A1 - Process for Preparing Insulin Esters - Google Patents

Process for Preparing Insulin Esters

Info

Publication number
ES8205858A1
ES8205858A1 ES499238A ES499238A ES8205858A1 ES 8205858 A1 ES8205858 A1 ES 8205858A1 ES 499238 A ES499238 A ES 499238A ES 499238 A ES499238 A ES 499238A ES 8205858 A1 ES8205858 A1 ES 8205858A1
Authority
ES
Spain
Prior art keywords
insulin
preparing insulin
insulin esters
esters
threonine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES499238A
Other languages
Spanish (es)
Other versions
ES499238A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novo Nordisk AS
Original Assignee
Novo Industri AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8095095&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES8205858(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novo Industri AS filed Critical Novo Industri AS
Publication of ES499238A0 publication Critical patent/ES499238A0/en
Publication of ES8205858A1 publication Critical patent/ES8205858A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Forklifts And Lifting Vehicles (AREA)

Abstract

Insulin and insulin-like compounds from certain species can in the presence of an L-threonine ester, water, a water miscible organic solvent, and trypsin be transpeptidized into a threonine<B30> ester of human insulin in which the protecting group(s) can be removed whereby human insulin is formed.
ES499238A 1980-02-11 1981-02-09 Process for Preparing Insulin Esters Expired ES8205858A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK57480A DK147109C (en) 1980-02-11 1980-02-11 METHOD FOR PREPARING HUMAN INSULIN OR HUMAN INSULINESTERS OR A SALT OR COMPLEX THEREOF

Publications (2)

Publication Number Publication Date
ES499238A0 ES499238A0 (en) 1982-08-01
ES8205858A1 true ES8205858A1 (en) 1982-08-01

Family

ID=8095095

Family Applications (1)

Application Number Title Priority Date Filing Date
ES499238A Expired ES8205858A1 (en) 1980-02-11 1981-02-09 Process for Preparing Insulin Esters

Country Status (19)

Country Link
JP (1) JPS56135452A (en)
AR (1) AR231277A1 (en)
AU (1) AU541528B2 (en)
BE (1) BE887480A (en)
CA (1) CA1162868A (en)
CH (1) CH655949A5 (en)
DE (1) DE3104949C2 (en)
DK (3) DK147109C (en)
ES (1) ES8205858A1 (en)
FI (1) FI77876C (en)
GB (1) GB2069502B (en)
GR (1) GR73844B (en)
IT (1) IT1195038B (en)
NL (1) NL178797C (en)
NO (1) NO156247C (en)
NZ (1) NZ196224A (en)
PT (1) PT72485B (en)
SE (2) SE451143B (en)
ZA (1) ZA81898B (en)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK147437A (en) 1980-02-11 1900-01-01 Process for preparing human insulin or threonine B30 esters of human insulin, or a salt or complex thereof
DE3101382A1 (en) * 1981-01-17 1982-09-02 Hoechst Ag, 6000 Frankfurt "METHOD FOR PRODUCING HUMANISULIN OR ITS DERIVATIVES FROM PIG INSULIN OR ITS DERIVATIVES"
EP0088117B1 (en) * 1981-09-15 1986-09-24 Nordisk Insulinlaboratorium Process for preparing human insulin or b-30 esters thereof
DK149824C (en) * 1982-01-22 1987-03-16 Carlsberg Biotechnology Ltd PROCEDURE FOR ENZYMATIC REPLACEMENT OF B-30 AMINO ACIDS IN INSULINES
EP0087238A1 (en) * 1982-02-08 1983-08-31 Biogen N.V. Am improved method for preparing human insulin from non-human insulin
DE3209184A1 (en) * 1982-03-13 1983-09-15 Hoechst Ag, 6230 Frankfurt METHOD FOR CONVERTING PRAEPROINSULIN ANALOGS TO INSULINES
NL8201650A (en) * 1982-04-21 1983-11-16 Akzo Nv SEMISYNTHETIC PREPARATION OF HUMANE INSULIN.
DK182483A (en) * 1982-04-23 1983-10-24 Wako Pure Chem Ind Ltd METHOD OF SEMI SYNTHESIS OF HUMAN INSULIN AND ALKALIC PROTEASE FOR USE THEREOF
DK55183D0 (en) * 1983-02-09 1983-02-09 Nordisk Insulinlab METHOD OF MANUFACTURING HUMAN INSULIN
DE3334407A1 (en) * 1983-09-23 1985-04-04 Hoechst Ag, 6230 Frankfurt INSULINE DERIVATIVES MODIFIED IN POSITION B 30, METHOD FOR THE PRODUCTION AND USE THEREOF AND PHARMACEUTICAL AGENTS FOR THE TREATMENT OF THE DIABETES MELLITUS
DK119785D0 (en) * 1985-03-15 1985-03-15 Nordisk Gentofte INSULIN PREPARATION
US5157021A (en) * 1985-03-15 1992-10-20 Novo Nordisk A/S Insulin derivatives and pharmaceutical preparations containing these derivatives
SE449472B (en) * 1985-10-15 1987-05-04 Mth Gruppen Ab EQUIPMENT AT FLOOR STORES
DE10075034I1 (en) * 1987-02-25 2001-05-23 Novo Nordisk As Insulin derivatives
DK134189D0 (en) * 1989-03-20 1989-03-20 Nordisk Gentofte INSULIN COMPOUNDS
FI96503C (en) * 1994-08-26 1996-07-10 Hymatic Ltd Oy Method and apparatus for controlling a mast
WO2005072803A1 (en) 2004-01-16 2005-08-11 Biodel, Inc. Sublingual drug delivery device
US20080090753A1 (en) 2004-03-12 2008-04-17 Biodel, Inc. Rapid Acting Injectable Insulin Compositions
US8084420B2 (en) 2005-09-29 2011-12-27 Biodel Inc. Rapid acting and long acting insulin combination formulations
US7713929B2 (en) 2006-04-12 2010-05-11 Biodel Inc. Rapid acting and long acting insulin combination formulations
CA2649109A1 (en) 2006-04-12 2007-10-25 Biodel, Inc. Rapid acting and long acting insulin combination formulations
US9060927B2 (en) 2009-03-03 2015-06-23 Biodel Inc. Insulin formulations for rapid uptake

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0017938B1 (en) * 1979-04-13 1983-08-03 Shionogi & Co., Ltd. Process for preparing a b30-threonine insulin
DK147437A (en) 1980-02-11 1900-01-01 Process for preparing human insulin or threonine B30 esters of human insulin, or a salt or complex thereof
DE3101382A1 (en) * 1981-01-17 1982-09-02 Hoechst Ag, 6000 Frankfurt "METHOD FOR PRODUCING HUMANISULIN OR ITS DERIVATIVES FROM PIG INSULIN OR ITS DERIVATIVES"

Also Published As

Publication number Publication date
FI810385L (en) 1981-08-12
PT72485A (en) 1981-03-01
AR231277A1 (en) 1984-10-31
CA1162868A (en) 1984-02-28
IT8119620A0 (en) 1981-02-10
DE3104949C2 (en) 1984-04-26
DK54081A (en) 1981-08-12
IT1195038B (en) 1988-09-28
NZ196224A (en) 1984-08-24
GR73844B (en) 1984-05-07
BE887480A (en) 1981-08-11
CH655949A5 (en) 1986-05-30
DK147437C (en) 1986-12-08
GB2069502B (en) 1984-08-08
GB2069502A (en) 1981-08-26
SE8100926L (en) 1982-08-11
AU541528B2 (en) 1985-01-10
DK147437B (en) 1984-08-06
SE8100928L (en) 1981-08-12
FI77876B (en) 1989-01-31
SE427025B (en) 1983-02-28
ES499238A0 (en) 1982-08-01
ZA81898B (en) 1982-03-31
NL178797C (en) 1986-05-16
NO156247B (en) 1987-05-11
JPS56135452A (en) 1981-10-22
DK147109C (en) 1986-12-08
DE3104949A1 (en) 1981-11-26
NL178797B (en) 1985-12-16
DK57480A (en) 1981-08-12
IT8119620A1 (en) 1982-08-10
JPH0211240B2 (en) 1990-03-13
NO810443L (en) 1981-08-12
PT72485B (en) 1982-10-14
SE451143B (en) 1987-09-07
FI77876C (en) 1989-05-10
AU6718081A (en) 1981-08-20
DK147437A (en) 1900-01-01
DK147109B (en) 1984-04-09
NL8100624A (en) 1981-09-01
NO156247C (en) 1987-08-19

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20020304