[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

ES8200887A1 - PROCEDURE FOR THE PREPARATION OF NEW 2- (PERHI-DRO-1,4-DIAZINO) -PIRIMIDO (5,4-D) PIRIMIDINAS - Google Patents

PROCEDURE FOR THE PREPARATION OF NEW 2- (PERHI-DRO-1,4-DIAZINO) -PIRIMIDO (5,4-D) PIRIMIDINAS

Info

Publication number
ES8200887A1
ES8200887A1 ES493016A ES493016A ES8200887A1 ES 8200887 A1 ES8200887 A1 ES 8200887A1 ES 493016 A ES493016 A ES 493016A ES 493016 A ES493016 A ES 493016A ES 8200887 A1 ES8200887 A1 ES 8200887A1
Authority
ES
Spain
Prior art keywords
formula
diazino
procedure
pirimidinas
perhi
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES493016A
Other languages
Spanish (es)
Other versions
ES493016A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Dr Karl Thomae GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19792926804 external-priority patent/DE2926804A1/en
Priority claimed from DE19803013930 external-priority patent/DE3013930A1/en
Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH
Publication of ES8200887A1 publication Critical patent/ES8200887A1/en
Publication of ES493016A0 publication Critical patent/ES493016A0/en
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE 2-(PERHIDRO-1,4-DIAZINO)-PIRIMIDO(5,4-D)-PIRIDINAS DE FORMULA (I) Y DE SUS SALES CON ACIDOS INORGANICOS Y ORGANICOS FISIOLOGICAMENTE COMPATIBLES, EN LA QUE R1, R2 Y R3 PUEDEN SER VARIOS TIPOS DE RADICALES Y N VALE 2 O 3. CONSISTE EN LA REACCION DE UNA PIRIMIDO(5,4-D)PIRIMIDINA DE FORMULA (II), EN LA QUE R1 Y R2 TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I), Y X ES UN GRUPO NUCLOFILO, CON UNA PERHIDRO-1,4-DIAZINA DE FORMULA (III), EN LA QUE N VALE 2 O 3 Y R3 TIENE EL MISMO SIGNIFICADO QUE R3 O REPRESENTA UN GRUPO PROTECTOR. LA REACCION SE LLEVA A CABO EN UN DISOLVENTE INERTE, EN PRESENCIA DE UNA BASE INORGANICA O UNA ORGANICA TERCIARIA Y DE UN CATALIZADOR A UNA TEMPERATURA COMPRENDIDAD ENTRE 20 Y 150 C.PROCEDURE FOR OBTAINING 2-(PERHYDRO-1,4-DIAZINO)-PYRIMID(5,4-D)-PYRIDINES OF FORMULA (I) AND ITS SALTS WITH PHYSIOLOGICALLY COMPATIBLE INORGANIC AND ORGANIC ACIDS, IN WHICH R1, R2 AND R3 CAN BE VARIOUS TYPES OF RADICALS AND N IS VALUE 2 OR 3. IT CONSISTS OF THE REACTION OF A PYRIMID(5,4-D)PYRIMIDINE OF FORMULA (II), IN WHICH R1 AND R2 HAVE THE SAME MEANING AS IN FORMULA ( I), AND X IS A NUCLOPHILIC GROUP, WITH A PERHYDRO-1,4-DIAZINE OF FORMULA (III), IN WHICH N IS VALUE 2 OR 3 AND R3 HAS THE SAME MEANING AS R3 OR REPRESENTS A PROTECTIVE GROUP. THE REACTION IS CARRIED OUT IN AN INERT SOLVENT, IN THE PRESENCE OF AN INORGANIC OR A TERTIARY ORGANIC BASE AND A CATALYST AT A TEMPERATURE BETWEEN 20 AND 150 C.

ES493016A 1979-07-03 1980-07-02 PROCEDURE FOR THE PREPARATION OF NEW 2- (PERHI-DRO-1,4-DIAZINO) -PIRIMIDO (5,4-D) PIRIMIDINAS Granted ES493016A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19792926804 DE2926804A1 (en) 1979-07-03 1979-07-03 NEW 2- (PERHYDRO-1,4-DIAZINO) -PYRIMIDO- SQUARE CLAMP ON 5.4-D SQUARE CLAMP FOR PYRIMIDINE, THEIR PRODUCTION AND USE AS MEDICINAL PRODUCT
DE19803013930 DE3013930A1 (en) 1980-04-11 1980-04-11 2-Per:hydro:diazine-pyrimido-pyrimidine derivs. - with antithrombotic activity, used e.g for prophylaxis of thromboembolic and arteriosclerosis

Publications (2)

Publication Number Publication Date
ES8200887A1 true ES8200887A1 (en) 1981-11-16
ES493016A0 ES493016A0 (en) 1981-11-16

Family

ID=25779815

Family Applications (1)

Application Number Title Priority Date Filing Date
ES493016A Granted ES493016A0 (en) 1979-07-03 1980-07-02 PROCEDURE FOR THE PREPARATION OF NEW 2- (PERHI-DRO-1,4-DIAZINO) -PIRIMIDO (5,4-D) PIRIMIDINAS

Country Status (15)

Country Link
US (3) US4518596A (en)
EP (1) EP0023559B1 (en)
AU (1) AU541307B2 (en)
CA (1) CA1145746A (en)
DE (1) DE3069211D1 (en)
DK (1) DK153487C (en)
ES (1) ES493016A0 (en)
FI (1) FI67220C (en)
GR (1) GR69326B (en)
IE (1) IE50139B1 (en)
IL (1) IL60454A (en)
NO (1) NO152843C (en)
NZ (1) NZ194228A (en)
PH (1) PH25388A (en)
PT (1) PT71478B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3049207A1 (en) * 1980-12-27 1982-07-29 Dr. Karl Thomae Gmbh, 7950 Biberach NEW TRISUBSTITUTED PYRIMIDO (5,4-D) PYRIMIDINE, THEIR PRODUCTION AND USE AS A MEDICINAL PRODUCT
DE3423092A1 (en) * 1984-06-22 1986-01-02 Dr. Karl Thomae Gmbh, 7950 Biberach NEW 8-ALKYLTHIO-2-PIPERAZINO-PYRIMIDO (5,4-D) PYRIMIDINE, THEIR PRODUCTION AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS
US4963541A (en) * 1989-02-22 1990-10-16 Abbott Laboratories Pyrimido-pyrimidine lipoxygenase inhibiting compounds
DE4325900A1 (en) * 1993-08-02 1995-02-09 Thomae Gmbh Dr K Trisubstituted pyrimido [5,4-d] pyrimidines for the modulation of multidrug resistance, pharmaceutical compositions containing them and methods for their preparation
TW414798B (en) * 1994-09-07 2000-12-11 Thomae Gmbh Dr K Pyrimido (5,4-d) pyrimidines, medicaments comprising these compounds, their use and processes for their preparation
DE19608653A1 (en) * 1996-03-06 1997-09-11 Thomae Gmbh Dr K Pyrimido [5,4-d] pyrimidines, medicaments containing these compounds, their use and processes for their preparation
DE102004002557A1 (en) * 2004-01-17 2005-08-04 Boehringer Ingelheim Pharma Gmbh & Co. Kg Use of substituted pyrimido (5,4-d) pyrimidines for the treatment of respiratory diseases

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT209344B (en) * 1958-06-26 1960-05-25 Thomae Gmbh Dr K Process for the preparation of derivatives of pyrimido [5,4-d] pyrimidine
US3031450A (en) * 1959-04-30 1962-04-24 Thomae Gmbh Dr K Substituted pyrimido-[5, 4-d]-pyrimidines

Also Published As

Publication number Publication date
PH25388A (en) 1991-06-03
DK284280A (en) 1981-01-04
DK153487B (en) 1988-07-18
NZ194228A (en) 1984-09-28
GR69326B (en) 1982-05-17
DK153487C (en) 1988-11-28
IL60454A0 (en) 1980-09-16
IE50139B1 (en) 1986-02-19
NO801989L (en) 1981-01-05
PT71478B (en) 1981-12-11
AU541307B2 (en) 1985-01-03
PT71478A (en) 1980-08-01
FI67220B (en) 1984-10-31
EP0023559A1 (en) 1981-02-11
EP0023559B1 (en) 1984-09-19
FI802102A (en) 1981-01-04
US4728646A (en) 1988-03-01
NO152843B (en) 1985-08-19
ES493016A0 (en) 1981-11-16
NO152843C (en) 1985-11-27
FI67220C (en) 1985-02-11
CA1145746A (en) 1983-05-03
US4518596A (en) 1985-05-21
IE801354L (en) 1981-01-03
DE3069211D1 (en) 1984-10-25
US4690923A (en) 1987-09-01
AU6004480A (en) 1981-01-15
IL60454A (en) 1985-04-30

Similar Documents

Publication Publication Date Title
ES8400415A1 (en) "A PROCEDURE FOR THE PREPARATION OF DERIVATIVES OF 2,4-DIAMINOQUINAZOLINE".
ES8705400A1 (en) A PROCEDURE FOR THE PREPARATION OF NEW DERIVATIVES OF PHENOXIALKYLAMINOPYRIMIDINE.
AR248138A1 (en) Heterocyclic derivatives of acylaminothiazole, their preparation and pharmaceutical compositions containing them
UY25671A1 (en) PROCEDURE FOR PREPARING 2-PHENYL SUBSTITUTED IMIDAZOTRAZINONES
ES8301998A1 (en) 7-(substituted or unsubstituted amino) 3-substituted methyl-3cephem-4-carboxylic acid
BG33153A3 (en) Method for obtaining of 1- aryloxy- 2- hydroxy- 3- alkylene
NO855134L (en) 6,7-DISUBSTITUTED 1-CYCLOPROPYL-1,4-DIHYDRO-4-OXO-1,8-NAFTYRIDINE-3-CARBOXYLIC ACIDS.
ES8200887A1 (en) PROCEDURE FOR THE PREPARATION OF NEW 2- (PERHI-DRO-1,4-DIAZINO) -PIRIMIDO (5,4-D) PIRIMIDINAS
ES2046384T3 (en) PREPARATION OF DYE FOR THE HAIR.
DE3782347D1 (en) HETARYL-OXY-BETA-CARBOLINE DERIVATIVES, THEIR PRODUCTION AND USE AS MEDICINAL PRODUCTS.
IT7828802A0 (en) PROCESS FOR THE PREPARATION OF AN AMINE.
BG31227A4 (en) Method for obtaining of racemic oropticallj active pjromido (1,2a) heterocjlic commpounds
AR220733A1 (en) PROCEDURE FOR PREPARING ACID DERIVATIVES 7- (2- (2-AMINO-4-THIAZOLYL) -METOXIMINO-ACETAMIDO) -3 (4-METHYL-5-OXO-6-HIDROXI-4,5-DIHIDRO-1,2, 4-TRIAZIN-3-IL-TIO) -METIL-3-CEFEM-4-CARBOXILICOS AND ITS SALTS
ES8606321A1 (en) Benzofuran derivatives, processes for preparing the same and antihypertensive agents containing the same.
SE7704616L (en) WAY TO PRODUCE NEW 11-DESOXY-PROSTAGLANDIN-FŸ2-DERIVATIVES
ES8704468A1 (en) PROCEDURE FOR PREPARING NEW 1,2,4-TRIAZOLE-CARBAMATES
IT7919819A0 (en) USE OF WATER-SOLUBLE BENZOXANTHENIC DYES FOR FLUORESCENT INKS.
IT8020504A0 (en) ISONICOTINOIL DERIVATIVES OF AMINO ACIDS WITH HERBICIDE ACTION.
ES8401969A1 (en) A PROCEDURE FOR THE PREPARATION OF A QUATERNARY AMMONIUM SALT.
ES476837A1 (en) Antiallergic nitrogen bridge-head compounds
ES8402157A1 (en) A PROCEDURE FOR THE PREPARATION OF CERTAIN CARBONATES OF 6- (2-AMINO-2-PHENYL-ACETAMIDE-PENICILANOYLOXIMETIL) -1,1-DIOXOPENICILANOILOXIMETILO AS ANTIBACTERIAL AGENTS.
BG30929A3 (en) Metod for obtaining of derivatives of 1, 3- benzoxazine- 2, 4- dion
ES8306154A1 (en) "PROCEDURE FOR THE PREPARATION OF NEW 6-METHODI-PENICILLINS".
AR247882A1 (en) Pyrimidin derivatives, process for their preparation, agents containing them and their use as fungicides
JPS5283652A (en) Benzanthrone derivatives

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970303