[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

ES8200871A1 - Procedimiento para la obtencion de derivados de 2-amino-3,4-dihidropiridina - Google Patents

Procedimiento para la obtencion de derivados de 2-amino-3,4-dihidropiridina

Info

Publication number
ES8200871A1
ES8200871A1 ES497579A ES497579A ES8200871A1 ES 8200871 A1 ES8200871 A1 ES 8200871A1 ES 497579 A ES497579 A ES 497579A ES 497579 A ES497579 A ES 497579A ES 8200871 A1 ES8200871 A1 ES 8200871A1
Authority
ES
Spain
Prior art keywords
amino
substituted
medicaments
preparation
dihydropyridine derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES497579A
Other languages
English (en)
Other versions
ES497579A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19792949701 external-priority patent/DE2949701A1/de
Priority claimed from DE19803016874 external-priority patent/DE3016874A1/de
Application filed by Bayer AG filed Critical Bayer AG
Publication of ES8200871A1 publication Critical patent/ES8200871A1/es
Publication of ES497579A0 publication Critical patent/ES497579A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO DE OBTENCION DE DERIVADOS DE 2-AMINO-3, 4-DIHIDROPIRIDINA DE FORMULA (I), DONDE R ES HIDROGENO, ALQUILO O UN GRUPO DE FORMULA (II), SIENDO R'' Y R'''' HIDROGENO, ALQUILO O ARALQUILO; R1 Y R2 SON ARILO O HEROARILO Y R3 Y R4 HIDROGENO, ALQUILO, ARALQUILO, ALQUENILO O ALQUINILO. SE HACE REACCIONAR, A TEMPERATURA DE 20-150 C, CANTIDADES EQUIMOLARES DE UN COMPUESTO OXO, -B-INSATURADO, DE FORMULA (III), Y DE UN ESTER DE ACIDO 3,3-DIAMINO-ACRILICO DE FORMULA (IV); O BIEN, CON SU FORMA IMINO TAUTOMERA, SIENDO R7 UN RESTO ALQUILO O ARALQUILO. LA REACCION SE EFECTUA EN UN DISOLVENTE ORGANICO INERTE Y OPCIONALMENTE EN PRESENCIA DE CATALIZADORES ACIDOS O BASICOS. DE APLICACION EN EL TRATAMIENTO DE LA HIPERLIPOPROTEINEMIAS, ARTEROESCLEROSIS, ADIPOSITAS Y TRASTORNOS DEL METABOLISMO.
ES497579A 1979-12-11 1980-12-10 Procedimiento para la obtencion de derivados de 2-amino-3,4-dihidropiridina Granted ES497579A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19792949701 DE2949701A1 (de) 1979-12-11 1979-12-11 Substituierte 2-amino-3,4-dihydropyridinderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE19803016874 DE3016874A1 (de) 1980-05-02 1980-05-02 Substituierte 2-amino-3,4-dihydropyridinderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel

Publications (2)

Publication Number Publication Date
ES8200871A1 true ES8200871A1 (es) 1981-11-16
ES497579A0 ES497579A0 (es) 1981-11-16

Family

ID=25782339

Family Applications (1)

Application Number Title Priority Date Filing Date
ES497579A Granted ES497579A0 (es) 1979-12-11 1980-12-10 Procedimiento para la obtencion de derivados de 2-amino-3,4-dihidropiridina

Country Status (9)

Country Link
US (1) US4442100A (es)
EP (1) EP0030343B1 (es)
AU (1) AU540498B2 (es)
CA (1) CA1181402A (es)
DE (1) DE3064716D1 (es)
DK (1) DK527180A (es)
ES (1) ES497579A0 (es)
GR (1) GR70670B (es)
NO (1) NO154840C (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3212736A1 (de) * 1982-04-06 1983-10-13 Bayer Ag, 5090 Leverkusen Verwendung von dihydropyridinen in arzneimitteln mit salidiuretischer wirkung
GB8431119D0 (en) * 1984-12-10 1985-01-16 Fujisawa Pharmaceutical Co Anti-arteriosclerotic composition
DE3447169A1 (de) * 1984-12-22 1986-07-03 Bayer Ag, 5090 Leverkusen Optisch aktive nitrodihydropyridine, verfahren zur herstellung und ihre verwendung in arzneimitteln
HU213257B (en) * 1991-06-11 1997-04-28 Boehringer Ingelheim Pharma Process for producing 4-alkyl-3-amino-2-chloropyridines
US5200522A (en) * 1991-06-11 1993-04-06 Boehringer Ingelheim Pharmaceuticals, Inc. Method for preparing 3-amino-2-chloro-4-alkylpyridines
DK2592934T3 (en) 2010-07-16 2015-10-26 Nivalis Therapeutics Inc NOVEL dihydropyridin-2 (1H) -one compounds as S-NITROSOGLUTATHIONREDUKTASEINHIBITORER and neurokinin-3 receptor antagonists

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4136187A (en) * 1972-08-12 1979-01-23 Bayer Aktiengesellschaft Antihypertensive 2-amino-4,5-dihydropyridine derivatives
DE2239815C2 (de) * 1972-08-12 1983-02-10 Bayer Ag, 5090 Leverkusen 2-Alkylamino-dihydropyridine, Verfahren zu ihrer Herstellung sowie diese enthaltende Arzneimittel

Also Published As

Publication number Publication date
NO154840B (no) 1986-09-22
EP0030343B1 (de) 1983-08-31
GR70670B (es) 1982-12-06
NO803551L (no) 1981-06-12
AU540498B2 (en) 1984-11-22
AU6527980A (en) 1981-06-18
US4442100A (en) 1984-04-10
ES497579A0 (es) 1981-11-16
NO154840C (no) 1987-01-07
DK527180A (da) 1981-06-12
EP0030343A1 (de) 1981-06-17
CA1181402A (en) 1985-01-22
DE3064716D1 (en) 1983-10-06

Similar Documents

Publication Publication Date Title
ES8104228A1 (es) Procedimiento para la obtencion de 1,4-dihidropiridinas op- ticamente activas
ES8402591A1 (es) Procedimiento para la obtencion de pirazolooxacinas, pirazolotiacinas y pirazoloquinolinas.
IL72120A0 (en) 2-pyrimidinyl-1-piperazine derivatives,their preparation and pharmaceutical compositions containing them
ES463633A1 (es) Procedimiento de preparacion de derivados de la piperidina.
IL58775A0 (en) Hydroxyethyl-azole compounds,their production and pharmaceutical compositions containing them
ES8203888A1 (es) Procedimiento para la obtencion de dihidropiridinas susti- tuidas en la posicion 4 del hetero-anillo
ES2052603T3 (es) Derivados de bencimidazol, procedimiento para su produccion y composicion farmaceutica que los contienen.
IL58782A (en) Hydroxypropyl-triazole compounds,their production and pharmaceutical compositions containing them
ES475633A1 (es) Procedimiento para la obtencion de derivados de 1-n-4,6-di-0-(aminoglicosil)-1,3-diamino-ciclitol.
ES8200094A1 (es) Procedimiento para la obtencion de alquilureas
IL64472A0 (en) Pharmaceutical compositions containing tricyclic cytosin derivatives,certain new compounds of this class and their production
AU6319480A (en) 2-hydroxyalkyl-3,4,5-trihydroxypiperidines
ES8103043A1 (es) Procedimiento para la obtencion de derivados de 2-hidroxime-til-3,4,5-trihidroxipiperidinas
ES478048A1 (es) Procedimiento para la obtencion de difenil-imidazolil-meta- nos sustituidos.
ES8106003A1 (es) Procedimiento para la obtencion de acido fosfonohidroxiace- tico
ES8200871A1 (es) Procedimiento para la obtencion de derivados de 2-amino-3,4-dihidropiridina
ES8102096A1 (es) Procedimiento para la obtencion de derivados de 3,4,5-trihi-droxipiperidina
ES8103112A1 (es) Procedimiento para la obtencion de pseudo-trisacaridos
ES8305783A1 (es) Procedimiento para la obtencion de derivados de aminociclitol saturados.
ES8203334A1 (es) Procedimiento para la obtencion de dehidropeptidos
ES8304937A1 (es) Procedimiento para la obtencion de derivados de 2-amino-piridina sustituidos.
ES474052A1 (es) Procedimiento para la obtencion de 1,4-dihidropiridazinas 1-n-sustituidas.
ES8203843A1 (es) Procedimiento para la obtencion de amidas de acido 1,4-dihi-dropiridin-4-carboxilico
ES471125A1 (es) Procedimiento para preparar derivados de 1-aminoindolina
IT1114485B (it) Derivati dell'idantoina procedimento per la loro produzione e composizioni che li contengono come ingrediente attivo

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970519