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ES8107211A1 - Un procedimiento para la preparacion de nuevos derivados de benzoxocina. - Google Patents

Un procedimiento para la preparacion de nuevos derivados de benzoxocina.

Info

Publication number
ES8107211A1
ES8107211A1 ES494130A ES494130A ES8107211A1 ES 8107211 A1 ES8107211 A1 ES 8107211A1 ES 494130 A ES494130 A ES 494130A ES 494130 A ES494130 A ES 494130A ES 8107211 A1 ES8107211 A1 ES 8107211A1
Authority
ES
Spain
Prior art keywords
group
hydrogen atom
alkyl
compounds
methano
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES494130A
Other languages
English (en)
Other versions
ES494130A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of ES494130A0 publication Critical patent/ES494130A0/es
Publication of ES8107211A1 publication Critical patent/ES8107211A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
    • C07C45/74—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups combined with dehydration
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/24—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing hydroxy groups
    • C07C49/245—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing hydroxy groups containing six-membered aromatic rings
    • C07C49/248—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing hydroxy groups containing six-membered aromatic rings having unsaturation outside the aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE BENZOXOCINA, DE SUS SALES Y BIOPRECURSORES FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE R1, R2 Y R5 PUEDEN SER VARIOS TIPOS DE RADICALES; R3 ES UN RADICAL ALQUILO C1-4 O BENCILO, Y R4 ES HIDROGENO O HALOGENO; COMPUESTOS QUE TIENEN APLICACION EN MEDICINA POR SU ACTIVIDAD ANSIOLITICA Y ANTILCONVULSIVA. SE BASA EN LA REACCION DE REDUCCION DE UN COMPUESTO DE FORMULA (II), EN LA QUE R3, R4 Y R5 TIENEN LA MISMA SIGNIFICACION QUE EN LA FORMULA (I), Y X ES EL GRUPO NOR6, SIENDO R6 HIDROGENO O UN RADICAL ACILO O ALQUILO. LA REDUCCION SE LLEVA A CABO EMPLEANDO UN METAL ALCALINO EN UN ALCOHOL Y/O AMONIACO LIQUIDO, O HIDRUROS METALICOS COMPLEJOS. DE ESTE MODO SE OBTIENE UN COMPUESTO DE FORMULA (I) EN LA QUE R1 Y R2 SON HIDROGENO, A PARTIR DEL CUAL SE PUEDEN OBTENER SUS DERIVADOS POR METODOS CONVENCIONALES. *FORMULA* E
ES494130A 1979-08-09 1980-08-08 Un procedimiento para la preparacion de nuevos derivados de benzoxocina. Expired ES8107211A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB7927800 1979-08-09
GB8014559 1980-05-01

Publications (2)

Publication Number Publication Date
ES494130A0 ES494130A0 (es) 1981-10-01
ES8107211A1 true ES8107211A1 (es) 1981-10-01

Family

ID=26272490

Family Applications (1)

Application Number Title Priority Date Filing Date
ES494130A Expired ES8107211A1 (es) 1979-08-09 1980-08-08 Un procedimiento para la preparacion de nuevos derivados de benzoxocina.

Country Status (5)

Country Link
US (1) US4315006A (es)
EP (1) EP0024843A1 (es)
AU (1) AU6119980A (es)
DK (1) DK344180A (es)
ES (1) ES8107211A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1582884A (en) * 1977-05-19 1981-01-14 Beecham Group Ltd Clavulanic acid derivatives their preparation and use
DK330880A (da) * 1979-08-03 1981-02-04 Beecham Group Ltd Fremgangsmaade til fremstilling af clavulansyrederivater
NZ199061A (en) * 1980-12-09 1984-10-19 Beecham Group Ltd 9-(n-tetrazolyl)-deoxyclavulanic acids,salts,esters,and pharmaceutical compositions
US4562182A (en) * 1980-12-23 1985-12-31 Beecham Group P.L.C. Compounds containing beta-lactams
DE3630539A1 (de) * 1986-09-08 1988-03-10 Madaus & Co Dr Derivate von 2,3,4,5,6,7-hexahydro-2,7-methano-1,5-benzoxazonin (bzw. -1,4-benzoxazonin), verfahren zu ihrer herstellung und arzneimittel, die diese verbindung enthalten
AU9102991A (en) * 1990-11-29 1992-06-25 Rhone-Poulenc Rorer International (Holdings) Inc. 2,6-methano-2h-1-benzoxocincarboxamides as 5-ht3-antagonists
FR2910002B1 (fr) * 2006-12-13 2009-01-30 Sanofi Aventis Sa Nouveau procede pour l'obtention diastereoselective d'une amine primaire chirale sur un steroide
US10898476B2 (en) 2016-04-13 2021-01-26 Orphazyme A/S Heat shock proteins and cholesterol homeostasis

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL132138C (es) * 1966-05-20
US3869475A (en) * 1973-04-05 1975-03-04 Yissum Res Dev Co 2,6-methano-benzoxacin compounds
GB1579137A (en) * 1976-07-06 1980-11-12 Lilly Co Eli 5-isopropylidene-2,6-methano-3,4,5,6-tetrahydro-2h-1-benzoxocins

Also Published As

Publication number Publication date
DK344180A (da) 1981-02-10
ES494130A0 (es) 1981-10-01
EP0024843A1 (en) 1981-03-11
AU6119980A (en) 1981-02-12
US4315006A (en) 1982-02-09

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