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ES8106482A1 - Un procedimiento para la preparacion de nuevos acidos feni- lalcanoicos - Google Patents

Un procedimiento para la preparacion de nuevos acidos feni- lalcanoicos

Info

Publication number
ES8106482A1
ES8106482A1 ES492955A ES492955A ES8106482A1 ES 8106482 A1 ES8106482 A1 ES 8106482A1 ES 492955 A ES492955 A ES 492955A ES 492955 A ES492955 A ES 492955A ES 8106482 A1 ES8106482 A1 ES 8106482A1
Authority
ES
Spain
Prior art keywords
phenyl
compound
group
preparation
pharmaceutical compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES492955A
Other languages
English (en)
Other versions
ES492955A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujisawa Pharmaceutical Co Ltd
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Publication of ES8106482A1 publication Critical patent/ES8106482A1/es
Publication of ES492955A0 publication Critical patent/ES492955A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • C07D213/643—2-Phenoxypyridines; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/56—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups bound to carbon atoms of six-membered aromatic rings and carboxyl groups bound to acyclic carbon atoms of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/14—Preparation of carboxylic acid nitriles by reaction of cyanides with halogen-containing compounds with replacement of halogen atoms by cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Toxicology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

PROCEDIMIENTO DE OBTENCION DE ACIDOS FENILALCANOICOS. CONSISTE EN SOMETER A HIDROLISIS A UN COMPUESTO DE FORMULA GENERAL (I). SE OBTIENE EL COMPUESTO (II), QUE OPCIONALMENTE SE HACE REACCIONAR CON UN AGENTE ACILANTE O ALQUILANTE, O BIEN DICHO COMPUESTO, O UN DERIVADO REACTIVO EN EL GRUPO CARBOXI O UNA SAL DEL MISMO, SE HACE REACCIONAR CON UNA AMIDA (III) PARA FORMAR UN GRUPO N-HETEROCICLICO; R'' ES FENILO O BENCILO; R CUADRADO ES HIDROGENO O HALOGENO; R ELEVADO A 4 ES UN GRUPO DE FORMULA CNH2NC SIENDO "N" DE 1 A 7; A ES OXI, SULFINILO, SULFONILO O *FORMULA*. ACTIVIDAD ANTINFLAMATORIA, ANALGESICA Y ANTIPIRETICA.
ES492955A 1978-08-08 1980-06-30 Un procedimiento para la preparacion de nuevos acidos feni- lalcanoicos Granted ES492955A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB7832609 1978-08-08

Publications (2)

Publication Number Publication Date
ES8106482A1 true ES8106482A1 (es) 1981-07-01
ES492955A0 ES492955A0 (es) 1981-07-01

Family

ID=10498927

Family Applications (3)

Application Number Title Priority Date Filing Date
ES483252A Expired ES483252A1 (es) 1978-08-08 1979-08-08 Un procedimiento para la preparacion de nuevos acidos feni- lalcanoicos.
ES492954A Granted ES492954A0 (es) 1978-08-08 1980-06-30 Un procedimiento para la preparacion de nuevos acidos feni- lalcanoicos
ES492955A Granted ES492955A0 (es) 1978-08-08 1980-06-30 Un procedimiento para la preparacion de nuevos acidos feni- lalcanoicos

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES483252A Expired ES483252A1 (es) 1978-08-08 1979-08-08 Un procedimiento para la preparacion de nuevos acidos feni- lalcanoicos.
ES492954A Granted ES492954A0 (es) 1978-08-08 1980-06-30 Un procedimiento para la preparacion de nuevos acidos feni- lalcanoicos

Country Status (15)

Country Link
US (1) US4472433A (es)
EP (1) EP0008226B1 (es)
JP (1) JPS5551041A (es)
AR (2) AR228019A1 (es)
AT (1) ATE5188T1 (es)
AU (1) AU526877B2 (es)
CA (1) CA1127160A (es)
DE (1) DE2966364D1 (es)
DK (1) DK331679A (es)
ES (3) ES483252A1 (es)
GR (1) GR68102B (es)
HU (1) HU184114B (es)
IE (1) IE48676B1 (es)
PH (1) PH22340A (es)
SU (2) SU1199197A3 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4333951A (en) * 1977-11-15 1982-06-08 A. H. Robins Company, Inc. 2-Amino-6-biphenylacetic acids
US4477556A (en) * 1982-08-18 1984-10-16 E. I. Du Pont De Nemours And Company Acidic o-nitroaromatics as photoinhibitors of polymerization in positive working films
JPS61206716A (ja) * 1985-03-12 1986-09-13 Sato Hisao 搬送ロ−ル
US4911754A (en) * 1987-07-16 1990-03-27 American Cyanamid Company Herbicidally active aryloxy saturated 5-membered benzo fused hetero-cyclic compounds
ES2058024B1 (es) * 1992-11-10 1995-05-01 Menarini Lab Nuevo derivado arilpropionico, procedimiento de fabricacion del mismo y su utilizacion como analgesico.
AU7070694A (en) * 1993-06-07 1995-01-03 Zeneca Limited Aniline derivatives
AU2001285311B2 (en) 2000-08-29 2005-09-15 Biocon, Ltd Immunoregulatory compounds, derivatives thereof and their use
JP2004529110A (ja) 2001-03-06 2004-09-24 アストラゼネカ アクチボラグ 脈管損傷活性を有するインドール誘導体
US8048924B2 (en) 2001-08-29 2011-11-01 Biocon Limited Methods and compositions employing 4-aminophenylacetic acid compounds
WO2006014549A2 (en) 2004-07-07 2006-02-09 Nobex Corporation Synthesis of azo bonded immunoregulatory compounds
US10980807B2 (en) 2016-02-09 2021-04-20 Inventisbio Llc Inhibitor of indoleamine-2,3-dioxygenase (IDO)

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1072998B (de) * 1960-01-14 Farbwerke Hoechst Aktiengesellschaft vormals Meister Lucius &. Brüning, Frankfurt/M Verfahren zur Herstellung von substituierten Diphenyläthern
FR1657M (fr) * 1961-01-14 1963-02-15 Merck Ag E 5-aleoxy-oxindoles
FR1516142A (fr) * 1967-01-24 1968-03-08 Rhone Poulenc Sa Nouveau procédé de préparation de dérivés de la phénothiazine
US3981905A (en) * 1970-03-16 1976-09-21 Boots Pure Drug Company Limited 2-(Substituted phenyl) propionic acids
JPS512358Y2 (es) * 1971-05-08 1976-01-23
BE795159A (fr) * 1972-02-08 1973-08-08 Thomae Gmbh Dr K Nouveaux acides butendiques, sels et derives de ces acides et procedes pour les preparer
CH569013A5 (es) * 1972-07-21 1975-11-14 Hoffmann La Roche
US4006161A (en) * 1973-12-26 1977-02-01 Eli Lilly And Company Thio-substituted 2-oxo-indolines
JPS511441A (ja) * 1974-06-19 1976-01-08 Fujisawa Pharmaceutical Co Fuenokishifuenirusakusanjudotaino seizoho
JPS511442A (ja) * 1974-06-19 1976-01-08 Fujisawa Pharmaceutical Co Fuenokishifuenirusakusanruino seizoho
JPS5487136A (en) * 1977-12-23 1979-07-11 Fujitsu Ltd Coupler between channels

Also Published As

Publication number Publication date
AR226446A1 (es) 1982-07-15
ATE5188T1 (de) 1983-11-15
PH22340A (en) 1988-08-12
GR68102B (es) 1981-10-30
SU1053743A3 (ru) 1983-11-07
ES483252A1 (es) 1980-09-01
ES8105690A1 (es) 1981-06-16
EP0008226A3 (en) 1980-03-05
EP0008226B1 (en) 1983-11-02
JPS5551041A (en) 1980-04-14
JPS6256861B2 (es) 1987-11-27
ES492955A0 (es) 1981-07-01
EP0008226A2 (en) 1980-02-20
DK331679A (da) 1980-02-09
SU1199197A3 (ru) 1985-12-15
ES492954A0 (es) 1981-06-16
CA1127160A (en) 1982-07-06
IE48676B1 (en) 1985-04-17
AU4946179A (en) 1981-02-05
US4472433A (en) 1984-09-18
AU526877B2 (en) 1983-02-03
IE791490L (en) 1980-02-08
HU184114B (en) 1984-07-30
DE2966364D1 (en) 1983-12-08
AR228019A1 (es) 1983-01-14

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