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ES8106129A1 - Un procedimiento para la preparacion de derivados de ciclo- hexadieno - Google Patents

Un procedimiento para la preparacion de derivados de ciclo- hexadieno

Info

Publication number
ES8106129A1
ES8106129A1 ES493544A ES493544A ES8106129A1 ES 8106129 A1 ES8106129 A1 ES 8106129A1 ES 493544 A ES493544 A ES 493544A ES 493544 A ES493544 A ES 493544A ES 8106129 A1 ES8106129 A1 ES 8106129A1
Authority
ES
Spain
Prior art keywords
cyclohexadienyl
phenyl
preparation
compositions containing
pharmaceutical compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES493544A
Other languages
English (en)
Other versions
ES493544A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of ES8106129A1 publication Critical patent/ES8106129A1/es
Publication of ES493544A0 publication Critical patent/ES493544A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/225—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing six-membered aromatic rings and other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
    • C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
    • C07C29/147—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of carboxylic acids or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/36—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal
    • C07C29/38—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal by reaction with aldehydes or ketones
    • C07C29/40—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal by reaction with aldehydes or ketones with compounds containing carbon-to-metal bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/29—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/20—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms
    • C07C47/235—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms containing six-membered aromatic rings and other rings
    • C07C47/238—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms containing six-membered aromatic rings and other rings having unsaturation outside the aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE CICLOHEXADIENO Y SUS SALES DE ADICION DE ACIDO, DE FORMULA (I), DONDE R ELEVADO A 1 Y R ELEVADO A 4 SON HIDROGENO O METILO, R CUADRADO ES HIDROGENO, METILO O ETILO Y R CUBO ES METILO O ETILO, CON LA SALVEDAD DE QUE UNO, AL MENOS, DE R ELEVADO A 1 Y R ELEVADO A 4 SEA HIDROGENO. CONSISTE EN ALQUILAR UNA AMINA DE FORMULA (II) CON HALURO DE AQLUILO O SULFATO DE DIALQUILO. LA ALQUILACION PUEDE LLEVARSE A CABO REDUCTIVAMENTE UTILIZANDO FORMALDEHIDO Y ACIDO FORMICO O MEDIANTE ACILACION Y REDUCCION. LOS COMPUESTOS OBTENIDOS PUEDEN TRANSFORMARSE EN LAS SALES CORRESPONDIENTES POR ADICION DE ACIDOS ORGANICOS O INORGANICOS. LOS DERIVADOS OBTENIDOS TIENEN APLICACION COMO ANALGESICOS. *FORMULA*
ES493544A 1978-10-11 1980-07-21 Un procedimiento para la preparacion de derivados de ciclo- hexadieno Granted ES493544A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH1055278 1978-10-11

Publications (2)

Publication Number Publication Date
ES8106129A1 true ES8106129A1 (es) 1981-07-16
ES493544A0 ES493544A0 (es) 1981-07-16

Family

ID=4364419

Family Applications (3)

Application Number Title Priority Date Filing Date
ES484890A Expired ES8200859A1 (es) 1978-10-11 1979-10-10 Un procedimiento para la preparacion de derivados de ciclo- hexadieno
ES493543A Expired ES8106128A1 (es) 1978-10-11 1980-07-21 Un procedimiento para la preparacion de derivados de ciclo- hexadieno
ES493544A Granted ES493544A0 (es) 1978-10-11 1980-07-21 Un procedimiento para la preparacion de derivados de ciclo- hexadieno

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES484890A Expired ES8200859A1 (es) 1978-10-11 1979-10-10 Un procedimiento para la preparacion de derivados de ciclo- hexadieno
ES493543A Expired ES8106128A1 (es) 1978-10-11 1980-07-21 Un procedimiento para la preparacion de derivados de ciclo- hexadieno

Country Status (23)

Country Link
US (1) US4269788A (es)
EP (1) EP0012801B1 (es)
JP (1) JPS5553248A (es)
AR (1) AR224135A1 (es)
AT (1) ATE817T1 (es)
AU (1) AU5163679A (es)
BR (1) BR7906487A (es)
CA (1) CA1130318A (es)
CS (1) CS213395B2 (es)
CU (1) CU35135A (es)
DE (1) DE2962464D1 (es)
DK (1) DK428079A (es)
ES (3) ES8200859A1 (es)
FI (1) FI792998A (es)
GR (1) GR72475B (es)
HU (1) HU180248B (es)
IE (1) IE48847B1 (es)
IL (1) IL58391A0 (es)
MC (1) MC1287A1 (es)
NO (1) NO147273C (es)
PH (1) PH15443A (es)
PT (1) PT70302A (es)
ZA (1) ZA795301B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH644580A5 (de) * 1980-01-29 1984-08-15 Hoffmann La Roche Cyclohexen-derivate.
US4535186A (en) * 1983-04-19 1985-08-13 American Home Products Corporation 2-Phenyl-2-(1-hydroxycycloalkyl or 1-hydroxycycloalk-2-enyl)ethylamine derivatives
WO2008044628A1 (fr) * 2006-10-06 2008-04-17 Tokai University Educational System Procédé de production de peptide thioester
CN106349128A (zh) * 2016-08-24 2017-01-25 天津德凯化工股份有限公司 一种新型染料中间体及由其制得的活性染料
CN106336368A (zh) * 2016-08-24 2017-01-18 天津德凯化工股份有限公司 一种染料中间体及其制备方法
US10654979B2 (en) 2017-08-18 2020-05-19 Becton, Dickinson And Company Amphiphilic graft copolymers

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1298527B (de) * 1962-06-09 1969-07-03 Knoll Ag Verfahren zur Herstellung bicyclisch substituierter Aminoalkane
DE1284421B (de) * 1962-06-09 1968-12-05 Knoll Ag Bicyclisch substituierte Aminoalkane und Verfahren zu ihrer Herstellung
DE1518545A1 (de) * 1965-04-01 1970-01-15 Boehringer Mannheim Gmbh Verfahren zur Herstellung neuer Phenylcyclohexylalkylamine und ihrer Salze
US3320283A (en) * 1965-07-06 1967-05-16 Parke Davis & Co Phenylcyclohexylmethylamine compounds
DE1518663A1 (de) * 1965-08-02 1969-12-18 Gruenenthal Chemie Basisch substituierte Cycloalken-derivate und Verfahren zu ihrer Herstellung
GB1122050A (en) * 1966-07-14 1968-07-31 Labofina Sa Process for the resolution of alpha-arylalkylamines into their optical antipodes
FR310213A (es) * 1968-01-17 1902-12-08
DE1907909A1 (de) * 1969-02-17 1970-12-03 Goedecke Ag Verfahren zur Herstellung neuer Cyclohexenderivate
US3928603A (en) * 1970-10-28 1975-12-23 Fuveau Sa New derivatives of alpha-methyl benzylamine in treating inflammation
US3864391A (en) * 1972-10-02 1975-02-04 Du Pont 2,5-Diphenylcycloaliphatic Alkylamines
GB1549174A (en) * 1975-05-08 1979-08-01 Lilly Industries Ltd Amine derivatives

Also Published As

Publication number Publication date
EP0012801A1 (de) 1980-07-09
IL58391A0 (en) 1980-01-31
ZA795301B (en) 1980-09-24
DK428079A (da) 1980-04-12
IE791930L (en) 1980-04-11
ES493543A0 (es) 1981-07-16
HU180248B (en) 1983-02-28
ATE817T1 (de) 1982-04-15
ES484890A0 (es) 1981-11-01
MC1287A1 (fr) 1980-07-22
PH15443A (en) 1983-01-18
PT70302A (en) 1979-11-01
DE2962464D1 (en) 1982-05-19
AR224135A1 (es) 1981-10-30
ES8200859A1 (es) 1981-11-01
ES8106128A1 (es) 1981-07-16
CA1130318A (en) 1982-08-24
CU35135A (en) 1982-08-24
GR72475B (es) 1983-11-11
JPS5553248A (en) 1980-04-18
AU5163679A (en) 1980-04-17
BR7906487A (pt) 1980-07-15
NO793267L (no) 1980-04-14
EP0012801B1 (de) 1982-04-07
NO147273C (no) 1983-03-09
CS213395B2 (en) 1982-04-09
NO147273B (no) 1982-11-29
FI792998A (fi) 1980-04-12
ES493544A0 (es) 1981-07-16
US4269788A (en) 1981-05-26
IE48847B1 (en) 1985-05-29

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