ES8102570A1 - Geminal Dihalogen Derivatives of Condensed Pyrimidin-4-one Compounds their Preparation and Pharmaceutical Compositions Containing them - Google Patents
Geminal Dihalogen Derivatives of Condensed Pyrimidin-4-one Compounds their Preparation and Pharmaceutical Compositions Containing themInfo
- Publication number
- ES8102570A1 ES8102570A1 ES491896A ES491896A ES8102570A1 ES 8102570 A1 ES8102570 A1 ES 8102570A1 ES 491896 A ES491896 A ES 491896A ES 491896 A ES491896 A ES 491896A ES 8102570 A1 ES8102570 A1 ES 8102570A1
- Authority
- ES
- Spain
- Prior art keywords
- compounds
- pharmaceutical compositions
- preparation
- lower alkyl
- compositions containing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B62/00—Reactive dyes, i.e. dyes which form covalent bonds with the substrates or which polymerise with themselves
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Immunology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
Abstract
Geminal dihalogen derivatives of condensed pyrimidine-4-one compounds of the general formula < IMAGE > [wherein R represents hydrogen, lower alkyl, or lower alkoxycarbonyl R<1> represents hydrogen, lower alkyl, ester group, carboxy or a derivative thereof, cyano, phenyl or halogen R<2> represents hydrogen, lower alkyl or phenyl X represents halogen n is the integer 0, 1 or 2] and the salts and optically active antipodes thereof are of interest as chemical intermediates some also exhibit a variety of physiological activities and may be formulated into pharmaceutical compositions in conventional manner. The novel compounds can be made by halogenating a corresponding starting material wherein one or both X-substituents are hydrogen.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU79CI1932A HU179443B (en) | 1979-05-11 | 1979-05-11 | Process for producing substituted geminal dihalogeno-derivatives of pyrido-square bracket-1,2-a-square closed-pyrimidines,pyrrolo-square bracket-1,2-a-square bracket closed-pyrimidines and pyrimido-square bracket-1,2,-a-square bracket closed-asepines |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES491896A0 ES491896A0 (en) | 1981-02-16 |
| ES8102570A1 true ES8102570A1 (en) | 1981-02-16 |
Family
ID=10994747
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES491896A Expired ES8102570A1 (en) | 1979-05-11 | 1980-05-12 | Geminal Dihalogen Derivatives of Condensed Pyrimidin-4-one Compounds their Preparation and Pharmaceutical Compositions Containing them |
Country Status (24)
| Country | Link |
|---|---|
| JP (1) | JPS5615286A (en) |
| AT (1) | AT377261B (en) |
| BE (1) | BE883217A (en) |
| CA (1) | CA1141379A (en) |
| CH (1) | CH646971A5 (en) |
| CS (1) | CS241025B2 (en) |
| DD (1) | DD150605A5 (en) |
| DE (1) | DE3017564A1 (en) |
| DK (1) | DK204680A (en) |
| ES (1) | ES8102570A1 (en) |
| FI (1) | FI68825C (en) |
| FR (1) | FR2456101A1 (en) |
| GB (1) | GB2051048B (en) |
| GR (1) | GR68518B (en) |
| HU (1) | HU179443B (en) |
| IL (1) | IL59967A (en) |
| IT (1) | IT1133085B (en) |
| LU (1) | LU82437A1 (en) |
| NL (1) | NL8002678A (en) |
| NO (1) | NO152607C (en) |
| PL (1) | PL124035B1 (en) |
| PT (1) | PT71213A (en) |
| SE (1) | SE441747B (en) |
| SU (1) | SU1151210A3 (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU178453B (en) * | 1979-05-11 | 1982-05-28 | Chinoin Gyogyszer Es Vegyeszet | Process for producing 9-hydrazino-4-oxo-6,7,8,9-tetrahydro-4h-p-pyrido-square bracket-1,2-a-square bracket closed-pyrimidine derivatives |
| US4395549A (en) | 1981-10-02 | 1983-07-26 | Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt. | 6-Hydrazono-pyrido[2,1-b] quinazoline-11 ones |
| IL69274A (en) * | 1982-08-05 | 1986-08-31 | Erba Farmitalia | (substituted amino)derivatives of 3-benzylidene-pyrrolo(2,1-b)quinazolin-9-ones and 6-benzylidene-pyrido(2,1-b)quinazolin-11-ones,their preparation and pharmaceutical compositions containing them |
| US5158952A (en) * | 1988-11-07 | 1992-10-27 | Janssen Pharmaceutica N.V. | 3-[2-[4-(6-fluoro-1,2-benzisoxozol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9 tetrahydro-9-hydroxy-2-methyl-4H-pyrido [1,2-a]pyrimidin-4-one, compositions and method of use |
| UA72189C2 (en) | 1997-11-17 | 2005-02-15 | Янссен Фармацевтика Н.В. | Aqueous suspensions of 9-hydroxy-risperidone fatty acid esters provided in submicron form |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH538494A (en) * | 1966-11-02 | 1973-06-30 | Chinoin Gyogyszer Es Vegyeszet | Process for the preparation of new homopyrimidazole derivatives |
| HU178496B (en) * | 1977-12-29 | 1982-05-28 | Chinoin Gyogyszer Es Vegyeszet | Process for preparing 6,7,8,9-tetrahydro-4h-pyrido/1,2-a/pyrimidine derivatives with antiallergic activity |
-
1979
- 1979-05-11 HU HU79CI1932A patent/HU179443B/en unknown
-
1980
- 1980-05-01 IL IL59967A patent/IL59967A/en unknown
- 1980-05-03 GR GR61852A patent/GR68518B/el unknown
- 1980-05-08 SE SE8003479A patent/SE441747B/en not_active IP Right Cessation
- 1980-05-08 DE DE19803017564 patent/DE3017564A1/en not_active Withdrawn
- 1980-05-08 CS CS803258A patent/CS241025B2/en unknown
- 1980-05-08 SU SU802920002A patent/SU1151210A3/en active
- 1980-05-09 FR FR8010481A patent/FR2456101A1/en active Granted
- 1980-05-09 PT PT71213A patent/PT71213A/en unknown
- 1980-05-09 IT IT67719/80A patent/IT1133085B/en active
- 1980-05-09 LU LU82437A patent/LU82437A1/en unknown
- 1980-05-09 AT AT0247580A patent/AT377261B/en not_active IP Right Cessation
- 1980-05-09 DK DK204680A patent/DK204680A/en not_active Application Discontinuation
- 1980-05-09 JP JP6161680A patent/JPS5615286A/en active Pending
- 1980-05-09 BE BE0/200550A patent/BE883217A/en not_active IP Right Cessation
- 1980-05-09 FI FI801512A patent/FI68825C/en not_active IP Right Cessation
- 1980-05-09 CA CA000351662A patent/CA1141379A/en not_active Expired
- 1980-05-09 GB GB8015469A patent/GB2051048B/en not_active Expired
- 1980-05-09 CH CH366380A patent/CH646971A5/en not_active IP Right Cessation
- 1980-05-09 NO NO801378A patent/NO152607C/en unknown
- 1980-05-09 NL NL8002678A patent/NL8002678A/en not_active Application Discontinuation
- 1980-05-10 PL PL1980224163A patent/PL124035B1/en unknown
- 1980-05-12 DD DD80221053A patent/DD150605A5/en unknown
- 1980-05-12 ES ES491896A patent/ES8102570A1/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| IT8067719A0 (en) | 1980-05-09 |
| BE883217A (en) | 1980-09-01 |
| CH646971A5 (en) | 1984-12-28 |
| FI801512A (en) | 1980-11-12 |
| NO152607B (en) | 1985-07-15 |
| GB2051048B (en) | 1983-01-19 |
| SU1151210A3 (en) | 1985-04-15 |
| DD150605A5 (en) | 1981-09-09 |
| PL224163A1 (en) | 1981-02-13 |
| PL124035B1 (en) | 1982-12-31 |
| GB2051048A (en) | 1981-01-14 |
| FI68825B (en) | 1985-07-31 |
| NL8002678A (en) | 1980-11-13 |
| DE3017564A1 (en) | 1980-11-13 |
| CS241025B2 (en) | 1986-03-13 |
| LU82437A1 (en) | 1980-07-31 |
| JPS5615286A (en) | 1981-02-14 |
| FR2456101B1 (en) | 1985-04-05 |
| AT377261B (en) | 1985-02-25 |
| IL59967A0 (en) | 1980-07-31 |
| CA1141379A (en) | 1983-02-15 |
| NO801378L (en) | 1980-11-12 |
| HU179443B (en) | 1982-10-28 |
| ES491896A0 (en) | 1981-02-16 |
| CS325880A2 (en) | 1985-06-13 |
| FI68825C (en) | 1985-11-11 |
| GR68518B (en) | 1982-01-11 |
| IL59967A (en) | 1984-05-31 |
| PT71213A (en) | 1980-06-01 |
| NO152607C (en) | 1985-10-23 |
| FR2456101A1 (en) | 1980-12-05 |
| ATA247580A (en) | 1984-07-15 |
| SE8003479L (en) | 1980-11-12 |
| DK204680A (en) | 1980-11-12 |
| IT1133085B (en) | 1986-07-09 |
| SE441747B (en) | 1985-11-04 |
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