ES544998A0 - Procedimiento para la preparacion de 2- (piridil e imidazolil)-indoles. - Google Patents

Procedimiento para la preparacion de 2- (piridil e imidazolil)-indoles.

Info

Publication number: ES544998A0
Authority: ES; Spain
Prior art keywords: imidazolil; piridil; indoles; procedure; preparation
Prior art date: 1983-05-17
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

ES544998A

Other languages

English (en)

Other versions

ES8706629A1 (es

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Novartis AG

Original Assignee

Ciba Geigy AG

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-05-17

Filing date

1985-07-09

Publication date

1987-07-01

1985-07-09 Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG

1987-07-01 Publication of ES8706629A1 publication Critical patent/ES8706629A1/es

1987-07-01 Publication of ES544998A0 publication Critical patent/ES544998A0/es

Status Expired legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/55—Acids; Esters
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pain & Pain Management (AREA)
Hematology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Diabetes (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Enzymes And Modification Thereof (AREA)

ES544998A 1983-05-17 1985-07-09 Procedimiento para la preparacion de 2- (piridil e imidazolil)-indoles. Expired ES8706629A1 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US06/495,367 US4511573A (en)	1983-05-17	1983-05-17	3-Substituted-2-(heteroaryl) indoles

Publications (2)

Publication Number	Publication Date
ES8706629A1 ES8706629A1 (es)	1987-07-01
ES544998A0 true ES544998A0 (es)	1987-07-01

Family

ID=23968361

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
ES532573A Expired ES8702906A1 (es)	1983-05-17	1984-05-17	Procedimiento para la preparacion de 2-(piridil e imidazolil)-indoles
ES544998A Expired ES8706629A1 (es)	1983-05-17	1985-07-09	Procedimiento para la preparacion de 2- (piridil e imidazolil)-indoles.
ES544997A Expired ES8706628A1 (es)	1983-05-17	1985-07-09	Procedimiento para la preparacion de 2-(piridil e imidazolil)-indoles.

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
ES532573A Expired ES8702906A1 (es)	1983-05-17	1984-05-17	Procedimiento para la preparacion de 2-(piridil e imidazolil)-indoles

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
ES544997A Expired ES8706628A1 (es)	1983-05-17	1985-07-09	Procedimiento para la preparacion de 2-(piridil e imidazolil)-indoles.

Country Status (22)

Country	Link
US (1)	US4511573A (es)
EP (1)	EP0129051B1 (es)
JP (1)	JPS59225181A (es)
KR (1)	KR890000521B1 (es)
AR (3)	AR241703A1 (es)
AT (1)	ATE54314T1 (es)
AU (1)	AU560255B2 (es)
CA (1)	CA1255679A (es)
DD (1)	DD223713A5 (es)
DE (1)	DE3482629D1 (es)
DK (1)	DK242584A (es)
ES (3)	ES8702906A1 (es)
FI (1)	FI83218C (es)
GR (1)	GR79935B (es)
HU (1)	HU197565B (es)
IE (1)	IE57446B1 (es)
IL (1)	IL71833A (es)
NO (1)	NO161801C (es)
NZ (1)	NZ208177A (es)
PH (1)	PH22245A (es)
PT (1)	PT78581A (es)
ZA (1)	ZA843679B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4536505A (en) *	1983-05-17	1985-08-20	Ciba-Geigy Corporation	Certain N-(pyridyl) indoles
US4675332A (en) *	1984-12-10	1987-06-23	Warner-Lambert Company	Acidic tetrazolyl substituted indole compounds and their use as antiallergy agents
US4609733A (en) *	1984-12-27	1986-09-02	Ciba-Geigy Corporation	3-keto-substituted-N-pyridylindoles
DE3780438T2 (de) *	1986-11-27	1993-01-28	Beecham Group Plc	N-substituierte cyclische amine, ihre herstellung sowie pharmazeutische zusammensetzungen die sie enthalten.
US4962105A (en) *	1987-10-19	1990-10-09	Ciba-Geigy Corporation	Potentiation of antihypertensive effect of ace inhibitors
US4996328A (en) *	1989-03-08	1991-02-26	Appleton Papers Inc.	Bis-(indolyl)ethylenes
EP0949259B1 (en)	1996-12-26	2001-06-20	Nikken Chemicals Company, Limited	N-hydroxyurea derivatives and medicinal compositions containing the same
AR072297A1 (es) *	2008-06-27	2010-08-18	Novartis Ag	Derivados de indol-2-il-piridin-3-ilo, composicion farmaceutica que los comprende y su uso en medicamentos para el tratamiento de enfermedades mediadas por la sintasa aldosterona.

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3468894A (en) *	1966-11-29	1969-09-23	Geigy Chem Corp	Certain 2-pyridyl-substituted indole derivatives
US3557142A (en) *	1968-02-20	1971-01-19	Sterling Drug Inc	4,5,6,7-tetrahydro-indole-lower-alkanoic acids and esters
GB2016452B (en) *	1978-02-18	1982-07-21	Kissei Pharmaceutical	Imidazole compounds
JPS6050190B2 (ja) *	1978-05-02	1985-11-07	小野薬品工業株式会社	イミダゾ−ル誘導体
DE2960547D1 (en) *	1978-02-24	1981-11-05	Pfizer Ltd	3-(imidazol-1-ylalkyl)indoles as selective inhibitors of thromboxane synthetase,pharmaceutical compositions thereof, and methods for preparing them
JPS55313A (en) *	1978-06-13	1980-01-05	Kissei Pharmaceut Co Ltd	Imidazole derivative
DK471479A (da) *	1978-12-13	1980-06-14	Pfizer	Fremgangsmaade til fremstilling af imidazolderivater og salte deraf
DK151884C (da) *	1979-03-07	1988-06-13	Pfizer	Analogifremgangsmaade til fremstilling af 3-(1-imidazolylalkyl)indolderivater eller farmaceutisk acceptable syreadditionssalte deraf
GB2045244B (en) *	1979-03-07	1983-01-26	Pfizer Ltd	3-1-(imidazolylalkyl) indoles
GR75101B (es) *	1980-10-23	1984-07-13	Pfizer
US4363912A (en) *	1980-12-15	1982-12-14	Pfizer Inc.	Indole thromboxane synthetase inhibitors
GB2102795A (en) *	1981-07-31	1983-02-09	Pfizer Ltd	Indole derivatives
ZA825413B (en) *	1981-08-26	1983-06-29	Pfizer	Thromboxane synthetase inhibitors, processes for their production, and pharmaceutical compositions comprising them
US4460777A (en) *	1981-11-19	1984-07-17	Ciba-Geigy Corporation	N-Substituted-2-pyridylindoles
GB2111050B (en) *	1981-11-19	1985-09-11	Ciba Geigy Ag	N-substituted-2-pyridylindoles
US4478842A (en) *	1981-11-19	1984-10-23	Ciba-Geigy Corporation	N-Substituted-2-pyridylindoles
US4436746A (en) *	1982-09-30	1984-03-13	Ciba-Geigy Corporation	Thromboxane synthetase inhibitory N-substituted-2-(1-imidazolyl)indoles

1983
- 1983-05-17 US US06/495,367 patent/US4511573A/en not_active Expired - Lifetime
1984
- 1984-05-14 DE DE8484105450T patent/DE3482629D1/de not_active Expired - Lifetime
- 1984-05-14 AT AT84105450T patent/ATE54314T1/de not_active IP Right Cessation
- 1984-05-14 EP EP84105450A patent/EP0129051B1/de not_active Expired - Lifetime
- 1984-05-14 FI FI841926A patent/FI83218C/fi not_active IP Right Cessation
- 1984-05-15 IL IL71833A patent/IL71833A/xx unknown
- 1984-05-15 CA CA000454326A patent/CA1255679A/en not_active Expired
- 1984-05-15 PT PT78581A patent/PT78581A/pt not_active IP Right Cessation
- 1984-05-15 GR GR74707A patent/GR79935B/el unknown
- 1984-05-16 AU AU28095/84A patent/AU560255B2/en not_active Ceased
- 1984-05-16 DD DD84263082A patent/DD223713A5/de not_active IP Right Cessation
- 1984-05-16 IE IE1212/84A patent/IE57446B1/en not_active IP Right Cessation
- 1984-05-16 KR KR1019840002657A patent/KR890000521B1/ko not_active IP Right Cessation
- 1984-05-16 NZ NZ208177A patent/NZ208177A/en unknown
- 1984-05-16 ZA ZA843679A patent/ZA843679B/xx unknown
- 1984-05-16 DK DK242584A patent/DK242584A/da not_active Application Discontinuation
- 1984-05-16 HU HU841892A patent/HU197565B/hu not_active IP Right Cessation
- 1984-05-16 NO NO841959A patent/NO161801C/no unknown
- 1984-05-16 PH PH30688A patent/PH22245A/en unknown
- 1984-05-16 JP JP59096751A patent/JPS59225181A/ja active Granted
- 1984-05-17 ES ES532573A patent/ES8702906A1/es not_active Expired
- 1984-05-17 AR AR84296691A patent/AR241703A1/es active
1985
- 1985-07-09 ES ES544998A patent/ES8706629A1/es not_active Expired
- 1985-07-09 ES ES544997A patent/ES8706628A1/es not_active Expired
1987
- 1987-03-31 AR AR87307165A patent/AR242204A1/es active
- 1987-03-31 AR AR87307164A patent/AR242202A1/es active

Also Published As

Publication number	Publication date
PT78581A (en)	1984-06-01
AU2809584A (en)	1984-11-22
FI83218C (fi)	1991-06-10
DK242584A (da)	1984-11-18
DD223713A5 (de)	1985-06-19
DK242584D0 (da)	1984-05-16
HUT34183A (en)	1985-02-28
HU197565B (en)	1989-04-28
EP0129051A2 (de)	1984-12-27
NO161801B (no)	1989-06-19
NO841959L (no)	1984-11-19
NZ208177A (en)	1987-09-30
IL71833A (en)	1987-11-30
ATE54314T1 (de)	1990-07-15
KR840009097A (ko)	1984-12-24
ES8706629A1 (es)	1987-07-01
FI83218B (fi)	1991-02-28
FI841926A0 (fi)	1984-05-14
AR241703A1 (es)	1992-11-30
US4511573A (en)	1985-04-16
KR890000521B1 (ko)	1989-03-20
ES8702906A1 (es)	1987-01-16
IE57446B1 (en)	1992-09-09
NO161801C (no)	1989-09-27
CA1255679A (en)	1989-06-13
JPH0442386B2 (es)	1992-07-13
ES532573A0 (es)	1987-01-16
IE841212L (en)	1984-11-17
PH22245A (en)	1988-07-01
GR79935B (es)	1984-10-31
DE3482629D1 (de)	1990-08-09
ES8706628A1 (es)	1987-07-01
EP0129051B1 (de)	1990-07-04
AR242202A1 (es)	1993-03-31
AR242204A1 (es)	1993-03-31
EP0129051A3 (en)	1986-07-02
FI841926A (fi)	1984-11-18
AU560255B2 (en)	1987-04-02
ES544997A0 (es)	1987-07-01
IL71833A0 (en)	1984-09-30
ZA843679B (en)	1986-04-30
JPS59225181A (ja)	1984-12-18

Publication	Publication Date	Title
ES534114A0 (es)	1985-04-01	Procedimiento para la preparacion de nuevas n-alcoxi y n-alquil-sulfonilaminosulfonilureas
ES538231A0 (es)	1986-03-16	Procedimiento para la preparacion de derivado de esfingosina.
ES533260A0 (es)	1985-02-01	Procedimiento para la preparacion de 13a-alquilgonanos
ES539822A0 (es)	1986-05-16	Procedimiento para la preparacion de pirazolopiridinas.
ES539038A0 (es)	1986-06-01	Procedimiento para la preparavion de 4h-3, l-benzoxazin-4-onas y compuestos relacionados
MX160796A (es)	1990-05-22	Procedimiento para la preparacion de 2-piridin-2-il metil-tio o sulfinil-benzimidazoles
ES517988A0 (es)	1984-01-01	Procedimiento para la preparacion de nuevas n-(4-indolil-piperidino-alcohil-bencimidazolonas sustituidas.
ES538621A0 (es)	1985-11-01	Procedimiento para la preparacion de fenolsulfonftaleinil-b-d-galactosidos
AR240926A1 (es)	1991-03-27	"procedimiento para la preparacion de 8-isopropil-6-dimetilamino metil-7-hidroxi-4-metil-cumarina".
ES515375A0 (es)	1984-04-01	Procedimiento para la preparacion de derivados de 3-piridilo y 2-piracinilo.
ES545153A0 (es)	1986-01-16	Procedimiento para la preparacion de n-piridilindoles
ES538464A0 (es)	1985-11-01	Procedimiento para la preparacion de derivados de acilamida.
ES546506A0 (es)	1986-02-16	Procedimiento para la preparacion de nuevos derivados de 3-fenil-4-cianopirrol.
AR240460A1 (es)	1990-04-30	Procedimeitno para la preparacion de derivados de antraciclina.
ES531911A0 (es)	1985-06-01	Procedimiento para la preparacion de nuevas 5-acil-2-(1h)-piridinonas.
ES544998A0 (es)	1987-07-01	Procedimiento para la preparacion de 2- (piridil e imidazolil)-indoles.
MX156242A (es)	1988-07-27	Procedimiento para la preparacion de eter-sulfonatos
ES535185A0 (es)	1985-09-01	Procedimiento para la preparacion de nuevas oxadiacinas
ES528114A0 (es)	1984-08-16	Procedimiento para la preparacion de hexanorbrassinolid-22-eteres
ES523990A0 (es)	1984-11-01	Procedimiento para la preparacion de furobenzoisoxazoles.
ES539626A0 (es)	1986-05-16	Procedimiento para la preparacion de nuevas 3-alcoxi-2-(n-pirrolidino)-n-pirimidinil-o-n-pirazinil propilaminas.
MX162546A (es)	1991-05-20	Procedimiento mejorado para la preparacion de 2-halogenoresorcinoles
ES531024A0 (es)	1985-05-16	Procedimiento para la preparacion de aminonitrilos
MX159538A (es)	1989-06-29	Procedimiento para la preparacion de 3-acil-2-nitrometilen-tetrahidro-2h-1,3-tiazina
AR228478A1 (es)	1983-03-15	Procedimiento para la preparacion de 1-oxido-n-(2-(5-dimetilamino-metilfuran-2-il-metiltio)-etil)-3-piridincarboxamida

Legal Events

Date	Code	Title	Description
1997-08-16	FD1A	Patent lapsed	Effective date: 19970612