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ES513088A0 - Un procedimiento para la preparacion de nuevos derivados amonicos mono y bis-cuaternarios de 2 beta, 16 beta-diamino-5 alfa-androstanos. - Google Patents

Un procedimiento para la preparacion de nuevos derivados amonicos mono y bis-cuaternarios de 2 beta, 16 beta-diamino-5 alfa-androstanos.

Info

Publication number
ES513088A0
ES513088A0 ES513088A ES513088A ES513088A0 ES 513088 A0 ES513088 A0 ES 513088A0 ES 513088 A ES513088 A ES 513088A ES 513088 A ES513088 A ES 513088A ES 513088 A0 ES513088 A0 ES 513088A0
Authority
ES
Spain
Prior art keywords
ammonial
beta
androstan
quarterly
diamino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES513088A
Other languages
English (en)
Other versions
ES8308889A1 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Akzo NV
Original Assignee
Akzo NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo NV filed Critical Akzo NV
Publication of ES513088A0 publication Critical patent/ES513088A0/es
Publication of ES8308889A1 publication Critical patent/ES8308889A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
    • C07J13/005—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 16 (17)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0018—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa
    • C07J1/0022—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/005—Ketals
    • C07J21/008—Ketals at position 17
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ES513088A 1981-06-15 1982-06-14 Un procedimiento para la preparacion de nuevos derivados amonicos mono y bis-cuaternarios de 2 beta, 16 beta-diamino-5 alfa-androstanos. Expired ES8308889A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8118365 1981-06-15

Publications (2)

Publication Number Publication Date
ES513088A0 true ES513088A0 (es) 1983-08-16
ES8308889A1 ES8308889A1 (es) 1983-08-16

Family

ID=10522526

Family Applications (1)

Application Number Title Priority Date Filing Date
ES513088A Expired ES8308889A1 (es) 1981-06-15 1982-06-14 Un procedimiento para la preparacion de nuevos derivados amonicos mono y bis-cuaternarios de 2 beta, 16 beta-diamino-5 alfa-androstanos.

Country Status (11)

Country Link
US (1) US4447425A (es)
EP (1) EP0067480B1 (es)
JP (1) JPS5813600A (es)
AU (1) AU551427B2 (es)
CA (1) CA1186681A (es)
DE (1) DE3261364D1 (es)
DK (1) DK268382A (es)
ES (1) ES8308889A1 (es)
FI (1) FI72731C (es)
HU (1) HU186074B (es)
IE (1) IE53463B1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1314870C (en) * 1983-08-02 1993-03-23 Arthur G. Schwartz Steroids useful as anti-cancer, anti-obesity, anti-hyperglycemic, anti-autoimmune and anti-hypercholesterolemic agents
US5714481A (en) * 1983-08-02 1998-02-03 Research Corporation Technologies, Inc. Derivatives of 5-androsten-17 ones and 5-androstan-17-ones
US5804576A (en) * 1983-08-02 1998-09-08 Research Corporation Technologies, Inc. Derivatives of 5-androsten-17-ones and 5-androstan-17-ones
US5656621A (en) * 1983-08-02 1997-08-12 Research Corporation Tech., Inc. Steroids useful as anti-cancer and anti-obesity agents
GB8708886D0 (en) * 1987-04-14 1987-05-20 Akzo Nv 2beta-morpholino-androstane derivatives
GB8804579D0 (en) * 1988-02-26 1988-03-30 Akzo Nv Novel 16-homo-piperidino-androstane derivatives & processes for their preparation
DE4232656C2 (de) * 1992-09-29 1995-01-12 Sigma Tau Ind Farmaceuti Cyclopentanperhydrophenanthren-17-furyl-3ß-derivate, Verfahren zu deren Herstellung und diese enthaltende pharmazeutischen Zusammensetzungen
CZ300694A3 (en) * 1993-12-02 1996-05-15 Akzo Nobel Nv Substituted 2beta-morpholinandrostane derivatives, process of their preparation, their use for preparing pharmaceutical preparations and pharmaceutical compositions containing thereof
IT1277700B1 (it) * 1995-12-22 1997-11-11 Poli Ind Chimica Spa Processo di preparazione di 2-beta, 16-beta-diamino 3-alfa, 17-beta- diacilossi 5-alfaandrostani, bloccanti neuromuscolari a struttura
MX2008000933A (es) * 2005-09-13 2008-03-26 Sicor Inc Bromuro de roncuronio puro.

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1138605A (en) * 1965-02-19 1969-01-01 Organon Labor Ltd Improvements in or relating to new 2-ß,16-ß-diamino-androstanes
GB1454749A (en) * 1972-11-29 1976-11-03 Akzo Nv 2beta, 16beta-diamino-androstanes and their preparation
ATE921T1 (de) * 1978-09-05 1982-05-15 Akzo N.V. Saeureadditionssalze von 2-beta, 16-beta-bis-piperidino-an drostan-16-beta-monoquaternaeren ammoniumderivaten und diese enthaltende pharmazeutische zusammensetzungen.
IE50675B1 (en) * 1979-12-12 1986-06-11 Akzo Nv Bis-and mono-quaternary ammonium derivatives of 2beta,16beta-dipiperidino-5alpha-androstanes,processes for their preparation and pharmaceutical preparations

Also Published As

Publication number Publication date
FI822131A0 (fi) 1982-06-14
FI72731B (fi) 1987-03-31
US4447425A (en) 1984-05-08
IE821365L (en) 1982-12-15
AU8483882A (en) 1982-12-23
FI72731C (fi) 1987-07-10
DE3261364D1 (en) 1985-01-10
JPS5813600A (ja) 1983-01-26
IE53463B1 (en) 1988-11-23
HU186074B (en) 1985-05-28
AU551427B2 (en) 1986-05-01
CA1186681A (en) 1985-05-07
JPH0249320B2 (es) 1990-10-29
EP0067480A1 (en) 1982-12-22
DK268382A (da) 1982-12-16
EP0067480B1 (en) 1984-11-28
ES8308889A1 (es) 1983-08-16

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19980202