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ES495819A0 - Procedimiento de preparar derivados 1,2,4-oxadiazolin-5-oni-cos - Google Patents

Procedimiento de preparar derivados 1,2,4-oxadiazolin-5-oni-cos

Info

Publication number
ES495819A0
ES495819A0 ES495819A ES495819A ES495819A0 ES 495819 A0 ES495819 A0 ES 495819A0 ES 495819 A ES495819 A ES 495819A ES 495819 A ES495819 A ES 495819A ES 495819 A0 ES495819 A0 ES 495819A0
Authority
ES
Spain
Prior art keywords
oxadiazolin
oni
cos
procedure
preparing derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES495819A
Other languages
English (en)
Other versions
ES8106725A1 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chinoin Private Co Ltd
Original Assignee
Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt filed Critical Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt
Publication of ES8106725A1 publication Critical patent/ES8106725A1/es
Publication of ES495819A0 publication Critical patent/ES495819A0/es
Granted legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4151,2-Diazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42Oxazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/475Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D217/00Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D217/00Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D217/00Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C07D217/16Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D271/00Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D271/00Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/061,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D273/00Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
    • C07D273/02Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00 having two nitrogen atoms and only one oxygen atom
    • C07D273/04Six-membered rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
ES495819A 1979-10-11 1980-10-10 Procedimiento de preparar derivados 1,2,4-oxadiazolin-5-oni-cos Granted ES495819A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU79CI1973A HU179951B (en) 1979-10-11 1979-10-11 Process for preparing 1,2,4-oxadiazolin-5-one derivatives and pharmaceutical compositions containing thereof

Publications (2)

Publication Number Publication Date
ES8106725A1 ES8106725A1 (es) 1981-09-16
ES495819A0 true ES495819A0 (es) 1981-09-16

Family

ID=10994764

Family Applications (1)

Application Number Title Priority Date Filing Date
ES495819A Granted ES495819A0 (es) 1979-10-11 1980-10-10 Procedimiento de preparar derivados 1,2,4-oxadiazolin-5-oni-cos

Country Status (23)

Country Link
US (1) US4365064A (es)
JP (1) JPS5661375A (es)
AT (1) AT375369B (es)
BE (1) BE885633A (es)
CA (1) CA1154019A (es)
CH (1) CH649547A5 (es)
CS (1) CS241032B2 (es)
DD (1) DD153550A5 (es)
DE (1) DE3037432A1 (es)
DK (1) DK149854C (es)
ES (1) ES495819A0 (es)
FI (2) FI71318C (es)
FR (1) FR2467203A1 (es)
GB (1) GB2059967B (es)
HU (1) HU179951B (es)
IL (1) IL61175A (es)
IT (1) IT1129305B (es)
NL (1) NL8005586A (es)
NO (1) NO154795C (es)
PL (3) PL132131B1 (es)
SE (1) SE452158B (es)
SU (1) SU1087519A1 (es)
YU (1) YU41738B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU180708B (en) * 1979-10-11 1983-04-29 Chinoin Gyogyszer Es Vegyeszet Process for preparing new 1,2,4-oxadiazine derivatives
MXPA02009216A (es) * 2000-03-20 2003-12-11 N Gene Res Lab Inc Derivados de amidoxima de acido propencarboxilico, un proceso para la preparacion de los mismos y composiciones farmaceuticas que los contienen.
WO2014100719A2 (en) 2012-12-21 2014-06-26 Epizyme, Inc. Prmt5 inhibitors and uses thereof
US9745291B2 (en) 2012-12-21 2017-08-29 Epizyme, Inc. PRMT5 inhibitors containing a dihydro- or tetrahydroisoquinoline and uses thereof
US10118918B2 (en) 2012-12-21 2018-11-06 Epizyme, Inc. PRMT5 inhibitors and uses thereof
JP2016505000A (ja) 2012-12-21 2016-02-18 エピザイム,インコーポレイティド Prmt5阻害剤およびその使用
US9611257B2 (en) 2012-12-21 2017-04-04 Epizyme, Inc. PRMT5 inhibitors and uses thereof
WO2016022605A1 (en) 2014-08-04 2016-02-11 Epizyme, Inc. Prmt5 inhibitors and uses thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1529700A (fr) * 1967-04-11 1968-06-21 Dausse Sa Lab Tertioaminoalcoyl oxadiazolinones et leur procédé de préparation
FR1575552A (es) * 1967-12-07 1969-07-25
US4038279A (en) * 1972-12-23 1977-07-26 Boehringer Ingelheim Gmbh N-aryl-n'-(phenyl-or phenoxy-alkyl)-piperazines and salts thereof
US3994891A (en) * 1974-12-20 1976-11-30 Armour Pharmaceutical Company Tetrahydroisoquinoline compounds
US4187220A (en) * 1977-08-30 1980-02-05 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara R.T. New O-(3-amino-2-hydroxy-propyl)-amidoxime derivatives, process for the preparation thereof and pharmaceutical compositions containing same
HU180708B (en) * 1979-10-11 1983-04-29 Chinoin Gyogyszer Es Vegyeszet Process for preparing new 1,2,4-oxadiazine derivatives

Also Published As

Publication number Publication date
ATA501380A (de) 1983-12-15
US4365064A (en) 1982-12-21
FR2467203A1 (fr) 1981-04-17
FR2467203B1 (es) 1985-03-22
IL61175A (en) 1984-08-31
SE8007025L (sv) 1981-04-12
DD153550A5 (de) 1982-01-13
NO154795B (no) 1986-09-15
CS241032B2 (en) 1986-03-13
ES8106725A1 (es) 1981-09-16
DK149854C (da) 1987-04-21
PL232293A1 (es) 1982-04-26
DK149854B (da) 1986-10-13
GB2059967B (en) 1983-06-02
NO803044L (no) 1981-04-13
IL61175A0 (en) 1980-11-30
IT8068555A0 (it) 1980-10-09
PL131451B1 (en) 1984-11-30
PL132131B1 (en) 1985-02-28
SE452158B (sv) 1987-11-16
PL227209A1 (es) 1981-12-11
FI803219L (fi) 1981-04-12
YU41738B (en) 1987-12-31
FI803220L (fi) 1981-04-12
NL8005586A (nl) 1981-04-14
FI71932B (fi) 1986-11-28
BE885633A (fr) 1981-02-02
PL131375B1 (en) 1984-11-30
PL232292A1 (es) 1982-04-26
DE3037432A1 (de) 1981-05-27
GB2059967A (en) 1981-04-29
JPS5661375A (en) 1981-05-26
SU1087519A1 (ru) 1984-04-23
YU259480A (en) 1984-02-29
FI71318B (fi) 1986-09-09
HU179951B (en) 1983-01-28
AT375369B (de) 1984-07-25
DK429780A (da) 1981-04-12
CS673780A2 (en) 1985-06-13
CA1154019A (en) 1983-09-20
FI71932C (fi) 1987-03-09
FI71318C (fi) 1986-12-19
CH649547A5 (de) 1985-05-31
NO154795C (no) 1986-12-29
IT1129305B (it) 1986-06-04

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970203