ES470383A1 - 99hydroxyethoxymethylguanine derivative and process for preparing same - Google Patents
99hydroxyethoxymethylguanine derivative and process for preparing sameInfo
- Publication number
- ES470383A1 ES470383A1 ES470383A ES470383A ES470383A1 ES 470383 A1 ES470383 A1 ES 470383A1 ES 470383 A ES470383 A ES 470383A ES 470383 A ES470383 A ES 470383A ES 470383 A1 ES470383 A1 ES 470383A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- compound
- derivative
- compounds
- prepared
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 5
- 150000001768 cations Chemical class 0.000 abstract 2
- 241000450599 DNA viruses Species 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 241000700605 Viruses Species 0.000 abstract 1
- MKUXAQIIEYXACX-UHFFFAOYSA-N aciclovir Chemical class N1C(N)=NC(=O)C2=C1N(COCCO)C=N2 MKUXAQIIEYXACX-UHFFFAOYSA-N 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 241001493065 dsRNA viruses Species 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 230000000865 phosphorylative effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Communicable Diseases (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
9-Hydroxyethoxymethylguanine derivatives of the formula I are prepared by reacting a compound of the formula II with a phosphorylating agent. The resulting compound of the formula I in which W and Z both denote hydrogen can be reacted with a base containing the desired cation or with a corresponding salt to give a compound of the formula I in which W and/or Z denote a pharmaceutically acceptable cation. The compounds of the formula I can also be prepared by the processes indicated in Claims 11 and 15. The compounds of the formula I are active against viruses, in particular against different types of DNA and RNA viruses.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US77177877A | 1977-02-24 | 1977-02-24 | |
| GB5390577 | 1977-12-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES470383A1 true ES470383A1 (en) | 1979-09-16 |
Family
ID=26267373
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES467300A Expired ES467300A1 (en) | 1977-02-24 | 1978-02-24 | 99hydroxyethoxymethylguanine derivative and process for preparing same |
| ES470383A Expired ES470383A1 (en) | 1977-02-24 | 1978-05-31 | 99hydroxyethoxymethylguanine derivative and process for preparing same |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES467300A Expired ES467300A1 (en) | 1977-02-24 | 1978-02-24 | 99hydroxyethoxymethylguanine derivative and process for preparing same |
Country Status (27)
| Country | Link |
|---|---|
| JP (1) | JPS53108999A (en) |
| AR (2) | AR219735A1 (en) |
| AT (1) | AT353286B (en) |
| AU (1) | AU521577B2 (en) |
| CA (1) | CA1094062A (en) |
| CH (1) | CH643858A5 (en) |
| DD (1) | DD134098A5 (en) |
| DE (1) | DE2808096A1 (en) |
| DK (1) | DK147198C (en) |
| ES (2) | ES467300A1 (en) |
| FI (1) | FI68402C (en) |
| FR (1) | FR2381781A1 (en) |
| GR (1) | GR64404B (en) |
| HU (1) | HU178808B (en) |
| IE (1) | IE46210B1 (en) |
| IL (1) | IL54130A0 (en) |
| IN (1) | IN149483B (en) |
| IT (1) | IT1105259B (en) |
| LU (1) | LU79126A1 (en) |
| MC (1) | MC1182A1 (en) |
| NL (1) | NL7802111A (en) |
| NO (1) | NO153260C (en) |
| NZ (1) | NZ186555A (en) |
| PH (1) | PH13996A (en) |
| PL (1) | PL114474B1 (en) |
| PT (1) | PT67706B (en) |
| SE (1) | SE430507B (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0015584A3 (en) * | 1979-03-12 | 1980-12-10 | Kailash Kumar Dr. Prof. Gauri | Nucleotides, methods for their preparation and medicaments |
| EP0145739B1 (en) * | 1983-05-24 | 1989-02-08 | Sri International | Novel antiviral agents |
| US5047533A (en) * | 1983-05-24 | 1991-09-10 | Sri International | Acyclic purine phosphonate nucleotide analogs |
| US4579849A (en) * | 1984-04-06 | 1986-04-01 | Merck & Co., Inc. | N-alkylguanine acyclonucleosides as antiviral agents |
| CS264222B1 (en) * | 1986-07-18 | 1989-06-13 | Holy Antonin | N-phosphonylmethoxyalkylderivatives of bases of pytimidine and purine and method of use them |
| WO1996033201A1 (en) * | 1995-04-21 | 1996-10-24 | Centre National De La Recherche Scientifique (Cnrs) | Acyclovir derivatives as antiviral agents |
| FR2733234B1 (en) * | 1995-04-21 | 1997-07-04 | Centre Nat Rech Scient | DERIVATIVES OF ACYCLOVIR AS ANTIVIRAL AGENTS |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1523865A (en) * | 1974-09-02 | 1978-09-06 | Wellcome Found | Purine compunds and salts thereof |
-
1978
- 1978-02-23 AU AU33560/78A patent/AU521577B2/en not_active Expired
- 1978-02-24 HU HU78WE571A patent/HU178808B/en unknown
- 1978-02-24 FR FR7805305A patent/FR2381781A1/en active Granted
- 1978-02-24 IL IL54130A patent/IL54130A0/en not_active IP Right Cessation
- 1978-02-24 DD DD78203838A patent/DD134098A5/en unknown
- 1978-02-24 NO NO780644A patent/NO153260C/en unknown
- 1978-02-24 AT AT134678A patent/AT353286B/en not_active IP Right Cessation
- 1978-02-24 PH PH20817A patent/PH13996A/en unknown
- 1978-02-24 DK DK85178A patent/DK147198C/en active
- 1978-02-24 IT IT48192/78A patent/IT1105259B/en active
- 1978-02-24 IE IE397/78A patent/IE46210B1/en not_active IP Right Cessation
- 1978-02-24 NL NL7802111A patent/NL7802111A/en not_active Application Discontinuation
- 1978-02-24 AR AR271214A patent/AR219735A1/en active
- 1978-02-24 LU LU79126A patent/LU79126A1/en unknown
- 1978-02-24 DE DE19782808096 patent/DE2808096A1/en active Granted
- 1978-02-24 NZ NZ186555A patent/NZ186555A/en unknown
- 1978-02-24 JP JP2077878A patent/JPS53108999A/en active Pending
- 1978-02-24 SE SE7802140A patent/SE430507B/en not_active IP Right Cessation
- 1978-02-24 CH CH204078A patent/CH643858A5/en not_active IP Right Cessation
- 1978-02-24 CA CA297,833A patent/CA1094062A/en not_active Expired
- 1978-02-24 GR GR55543A patent/GR64404B/en unknown
- 1978-02-24 PT PT67706A patent/PT67706B/en unknown
- 1978-02-24 PL PL1978204885A patent/PL114474B1/en unknown
- 1978-02-24 ES ES467300A patent/ES467300A1/en not_active Expired
- 1978-02-24 FI FI780626A patent/FI68402C/en not_active IP Right Cessation
- 1978-02-24 MC MC781287A patent/MC1182A1/en unknown
- 1978-02-24 IN IN205/CAL/78A patent/IN149483B/en unknown
- 1978-05-31 ES ES470383A patent/ES470383A1/en not_active Expired
-
1979
- 1979-04-27 AR AR276336A patent/AR218718A1/en active
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19980401 |