ES476314A1 - Thio propionamides, processes for their preparation and pharmaceutical compositions containing them - Google Patents
Thio propionamides, processes for their preparation and pharmaceutical compositions containing themInfo
- Publication number
- ES476314A1 ES476314A1 ES476314A ES476314A ES476314A1 ES 476314 A1 ES476314 A1 ES 476314A1 ES 476314 A ES476314 A ES 476314A ES 476314 A ES476314 A ES 476314A ES 476314 A1 ES476314 A1 ES 476314A1
- Authority
- ES
- Spain
- Prior art keywords
- lower alkyl
- group
- formula
- amino
- pharmaceutical compositions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- -1 Thio propionamides Chemical class 0.000 title abstract 4
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000002947 alkylene group Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 206010020772 Hypertension Diseases 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 239000005864 Sulphur Substances 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 150000007530 organic bases Chemical class 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D277/06—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/12—1,4-Thiazines; Hydrogenated 1,4-thiazines not condensed with other rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
Abstract
The invention provides compounds of the formula < IMAGE > in which R is a hydrogen atom, a lower alkyl, lower alkenyl or aryl-lower alkyl group or the acyl radical of a lower alkyl-carboxylic acid or an aryl- carboxylic acid each having up to 10 carbon atoms R1 is a hydroxy, lower alkoxy, di- (lower alkyl)-amino-lower alkoxy, amino, monosubstituted amino, disubstituted amino or dihydroxy-lower alkyl group A and B together are a lower alkylene group of the formula (CH2)m-CH2-, a group of the formula < IMAGE > a group of the formula (CH2)ml- CH = CH or a disubstituted lower alkylene group of the formula < IMAGE > Z is sulphur or a sulphinyl or sulphonyl group R' is a hydrogen atom or a lower alkyl group R'' is a lower alkyl group n is zero or 1 m is 1 or 2 m1 is zero, 1 or 2 and m2 is 1 or 2 and their diastereoisomers, optically active isomers and salts with inorganlc and organic bases. The invention also provides a process for preparing such compounds, and pharmaceutical compositions containing them. The compounds may be used in the treatment of hypertension.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7738728A FR2412537A1 (en) | 1977-12-22 | 1977-12-22 | NEW SUBSTITUTE THIOBUTYRAMIDES, THEIR METHODS OF OBTAINING AND THEIR PHARMACEUTICAL APPLICATION |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES476314A1 true ES476314A1 (en) | 1979-04-16 |
Family
ID=9199179
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES476314A Expired ES476314A1 (en) | 1977-12-22 | 1978-12-22 | Thio propionamides, processes for their preparation and pharmaceutical compositions containing them |
Country Status (14)
| Country | Link |
|---|---|
| AR (1) | AR222815A1 (en) |
| BE (1) | BE872972A (en) |
| DD (1) | DD142545A5 (en) |
| DE (1) | DE2854877A1 (en) |
| ES (1) | ES476314A1 (en) |
| FR (1) | FR2412537A1 (en) |
| GB (1) | GB2014132B (en) |
| GR (1) | GR66839B (en) |
| IT (1) | IT1158184B (en) |
| OA (1) | OA06139A (en) |
| PT (1) | PT68966A (en) |
| SE (1) | SE7813180L (en) |
| SU (1) | SU860696A1 (en) |
| ZA (1) | ZA787196B (en) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1109475A (en) * | 1978-07-27 | 1981-09-22 | Miguel A. Ondetti | Thiopropanoylamino acid derivatives |
| US4483861A (en) * | 1978-10-31 | 1984-11-20 | Santen Pharmaceutical Co., Ltd. | Antihypertensive sulfur-containing compounds |
| ZA802420B (en) * | 1979-05-18 | 1981-04-29 | Squibb & Sons Inc | Aminoacyl derivatives of mercaptoacyl amino acids |
| ZA802709B (en) * | 1979-05-30 | 1981-05-27 | Merrell Toraude & Co | N-acyl-amino acid derivatives |
| US4308392A (en) | 1979-12-03 | 1981-12-29 | E. R. Squibb & Sons, Inc. | Hydroxamic acid derivatives of mercaptoacyl amino acids |
| US4284561A (en) | 1979-12-03 | 1981-08-18 | E. R. Squibb & Sons, Inc. | Hydroxamic acid derivatives of mercaptoacyl amino acids |
| JPS5683483A (en) * | 1979-12-13 | 1981-07-08 | Santen Pharmaceut Co Ltd | Thiazolidine compound |
| JPS56139455A (en) * | 1980-04-02 | 1981-10-30 | Santen Pharmaceut Co Ltd | Sulfur-containing acylaminoacid |
| US4482725A (en) * | 1980-04-03 | 1984-11-13 | E. R. Squibb & Sons, Inc. | S-Acylation products of mercaptoacyl amino acids and carboxyl group containing diuretics |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4052511A (en) * | 1976-02-13 | 1977-10-04 | E. R. Squibb & Sons, Inc. | Carboxyacylproline derivatives |
| AU509899B2 (en) * | 1976-02-13 | 1980-05-29 | E.R. Squibb & Sons, Inc. | Proline derivatives and related compounds |
-
1977
- 1977-12-22 FR FR7738728A patent/FR2412537A1/en active Granted
-
1978
- 1978-12-19 DE DE19782854877 patent/DE2854877A1/en not_active Ceased
- 1978-12-21 ZA ZA00787196A patent/ZA787196B/en unknown
- 1978-12-21 IT IT52406/78A patent/IT1158184B/en active
- 1978-12-21 PT PT68966A patent/PT68966A/en unknown
- 1978-12-21 SE SE7813180A patent/SE7813180L/en unknown
- 1978-12-21 BE BE192487A patent/BE872972A/en unknown
- 1978-12-21 GR GR57961A patent/GR66839B/el unknown
- 1978-12-21 AR AR274935A patent/AR222815A1/en active
- 1978-12-22 DD DD78210134A patent/DD142545A5/en unknown
- 1978-12-22 GB GB7849881A patent/GB2014132B/en not_active Expired
- 1978-12-22 ES ES476314A patent/ES476314A1/en not_active Expired
- 1978-12-22 SU SU782704624A patent/SU860696A1/en active
- 1978-12-22 OA OA56695A patent/OA06139A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| OA06139A (en) | 1981-06-30 |
| BE872972A (en) | 1979-06-21 |
| DE2854877A1 (en) | 1979-06-28 |
| GB2014132A (en) | 1979-08-22 |
| FR2412537A1 (en) | 1979-07-20 |
| GB2014132B (en) | 1982-08-11 |
| SE7813180L (en) | 1979-06-23 |
| AR222815A1 (en) | 1981-06-30 |
| GR66839B (en) | 1981-05-04 |
| FR2412537B1 (en) | 1981-10-16 |
| PT68966A (en) | 1979-01-01 |
| ZA787196B (en) | 1979-11-28 |
| DD142545A5 (en) | 1980-07-02 |
| IT1158184B (en) | 1987-02-18 |
| IT7852406A0 (en) | 1978-12-21 |
| SU860696A1 (en) | 1981-08-30 |
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