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ES476117A1 - Steroid cyanoketones and intermediates - Google Patents

Steroid cyanoketones and intermediates

Info

Publication number
ES476117A1
ES476117A1 ES476117A ES476117A ES476117A1 ES 476117 A1 ES476117 A1 ES 476117A1 ES 476117 A ES476117 A ES 476117A ES 476117 A ES476117 A ES 476117A ES 476117 A1 ES476117 A1 ES 476117A1
Authority
ES
Spain
Prior art keywords
cyanoketones
steroid
intermediates
alpha
steroido
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES476117A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
STWB Inc
Original Assignee
Sterling Drug Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sterling Drug Inc filed Critical Sterling Drug Inc
Publication of ES476117A1 publication Critical patent/ES476117A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0033—Androstane derivatives substituted in position 17 alfa and 17 beta
    • C07J1/004—Androstane derivatives substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being an unsaturated hydrocarbon group
    • C07J1/0048—Alkynyl derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0018—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa
    • C07J1/0022—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0033—Androstane derivatives substituted in position 17 alfa and 17 beta
    • C07J1/0037—Androstane derivatives substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being a saturated hydrocarbon group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0036—Nitrogen-containing hetero ring
    • C07J71/0057—Nitrogen and oxygen
    • C07J71/0063—Nitrogen and oxygen at position 2(3)

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

2 alpha -Cyano-3-oxosteroids having a 4 alpha ,5 alpha -epoxy group and alkylated in the 4- and/or 6-position, useful as interceptive agents, are prepared by alkaline cleavage of the corresponding steroido[2,3-d]isoxazoles.
ES476117A 1977-12-20 1978-12-19 Steroid cyanoketones and intermediates Expired ES476117A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/862,417 US4160027A (en) 1977-12-20 1977-12-20 Steroid cyanoketones and intermediates

Publications (1)

Publication Number Publication Date
ES476117A1 true ES476117A1 (en) 1979-11-16

Family

ID=25338450

Family Applications (1)

Application Number Title Priority Date Filing Date
ES476117A Expired ES476117A1 (en) 1977-12-20 1978-12-19 Steroid cyanoketones and intermediates

Country Status (27)

Country Link
US (1) US4160027A (en)
JP (2) JPS5488253A (en)
AR (1) AR222645A1 (en)
AT (1) AT367070B (en)
AU (1) AU518997B2 (en)
BE (1) BE872886A (en)
CA (1) CA1121340A (en)
CH (1) CH637409A5 (en)
DE (1) DE2855091A1 (en)
DK (1) DK156727C (en)
ES (1) ES476117A1 (en)
FI (1) FI66010C (en)
FR (1) FR2412569A1 (en)
GB (2) GB2010278B (en)
HK (1) HK89287A (en)
IE (1) IE48076B1 (en)
IL (1) IL56076A (en)
IT (1) IT1195258B (en)
LU (1) LU80673A1 (en)
MX (1) MX5535E (en)
NL (1) NL190848C (en)
NO (1) NO151467C (en)
NZ (1) NZ189035A (en)
PH (2) PH14778A (en)
PT (1) PT68926A (en)
SE (1) SE433221B (en)
ZA (1) ZA786746B (en)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4349474A (en) * 1981-07-27 1982-09-14 G. D. Searle & Co. 2-Cyanosteroids
ES526874A0 (en) * 1982-11-02 1985-05-01 Sterwin Ag STEROID COMPOSITE CRUSHING PROCEDURE
DK23984A (en) * 1983-02-11 1984-08-12 Hoffmann La Roche D-homosteroids
US4459235A (en) * 1983-03-03 1984-07-10 G. D. Searle & Co. 2-Cyanosteroids
GB8328929D0 (en) * 1983-10-29 1983-11-30 Sterwin Ag Steroid compounds
GB8404980D0 (en) * 1984-02-25 1984-03-28 Sterwin Ag Steroid compound
DE3531903A1 (en) * 1985-09-05 1987-03-12 Schering Ag OXYTOCIN AND ANTI-DAYS FOR THE INTRODUCTION OF BIRTH OR ON THE THERAPEUTIC STOP OF GRAVIDITY
US4755595A (en) * 1985-11-01 1988-07-05 Sterling Drug Inc. Enhanced production of 4,5-unsaturated steroids utilizing methanol solvation
US4870068A (en) * 1986-05-22 1989-09-26 Sterling Drug Inc. Method of regulating fertility in swine using epostane
US4833133A (en) * 1986-05-22 1989-05-23 Sterling Drug Inc. Method of regulating fertility in cattle using epostane
US5795881A (en) * 1987-06-16 1998-08-18 Schering Aktiengesellschaft Combined use of an antigestagen and a progesterone synthesis inhibitor of the trilostane and epostane type
US5215978A (en) * 1989-06-16 1993-06-01 The Upjohn Company Method of enhancing egg laying in turkeys using epostane
JPH0538929A (en) * 1991-08-02 1993-02-19 Mitsubishi Heavy Ind Ltd Air conditioner for vehicle
GB2375958B (en) * 2001-04-09 2005-03-02 George Margetts The use of steroids to lower the levels of cortisol
GB2414238B (en) * 2004-05-22 2006-12-13 Stegram Pharmaceuticals Ltd Method for the preparation of trilostane
EP2446888A3 (en) * 2005-07-12 2012-08-15 DMI Biosciences, Inc. Use of danazol for the treatment of uveitis
PL2554172T3 (en) * 2009-06-22 2015-03-31 Ampio Pharmaceuticals Inc Method for treatment of diseases
US20100323991A1 (en) * 2009-06-22 2010-12-23 Dmi Acquisition Corp. Methods and products for treatment of diseases
EA201500752A1 (en) 2012-12-19 2016-05-31 Ампио Фармасьютикалс, Инк. METHOD OF TREATMENT OF DISEASES

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3296255A (en) * 1963-11-29 1967-01-03 Sterling Drug Inc 2-cyano steroids
US3980638A (en) * 1974-09-20 1976-09-14 The Upjohn Company Testosterone derivatives
US4062954A (en) * 1976-12-27 1977-12-13 Sterling Drug Inc. Process for using a steroid compound

Also Published As

Publication number Publication date
AU4208978A (en) 1979-06-28
FI783901A (en) 1979-06-21
FR2412569A1 (en) 1979-07-20
AU518997B2 (en) 1981-10-29
NL7812309A (en) 1979-06-22
DK156727C (en) 1990-03-12
SE7813067L (en) 1979-06-21
IE48076B1 (en) 1984-09-19
DE2855091A1 (en) 1979-06-28
JPS5488253A (en) 1979-07-13
NL190848B (en) 1994-04-18
GB2010278B (en) 1982-10-20
NO784281L (en) 1979-06-21
DK156727B (en) 1989-09-25
DE2855091C2 (en) 1988-12-22
GB2010278A (en) 1979-06-27
NO151467B (en) 1985-01-02
SE433221B (en) 1984-05-14
US4160027A (en) 1979-07-03
HK89287A (en) 1987-12-11
DK569678A (en) 1979-06-21
NL190848C (en) 1994-09-16
FI66010B (en) 1984-04-30
MX5535E (en) 1983-09-27
PH16835A (en) 1984-03-15
PH14778A (en) 1981-12-09
PT68926A (en) 1979-01-01
ATA888578A (en) 1981-10-15
GB2088878A (en) 1982-06-16
IL56076A (en) 1983-06-15
AT367070B (en) 1982-05-25
IT1195258B (en) 1988-10-12
GB2088878B (en) 1983-01-19
LU80673A1 (en) 1979-07-20
CA1121340A (en) 1982-04-06
ZA786746B (en) 1979-11-28
BE872886A (en) 1979-06-20
FI66010C (en) 1984-08-10
AR222645A1 (en) 1981-06-15
FR2412569B1 (en) 1982-05-28
JPS6361314B2 (en) 1988-11-28
CH637409A5 (en) 1983-07-29
NZ189035A (en) 1980-08-26
JPS62142198A (en) 1987-06-25
JPS6220998B2 (en) 1987-05-11
NO151467C (en) 1985-04-17
IE782492L (en) 1979-06-20
IT7831011A0 (en) 1978-12-19
IL56076A0 (en) 1979-01-31

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Legal Events

Date Code Title Description
PC2A Transfer of patent

Owner name: STERLING WINTHROP INC.

PC1A Transfer granted
FD1A Patent lapsed

Effective date: 20010301