ES475533A1 - Un metodo para la preparacion de formas racemicas y optica- mente activas de 2-(4-difenilil)-n-(dimetilamino-alquil)pro-pionamida - Google Patents
Un metodo para la preparacion de formas racemicas y optica- mente activas de 2-(4-difenilil)-n-(dimetilamino-alquil)pro-pionamidaInfo
- Publication number
- ES475533A1 ES475533A1 ES475533A ES475533A ES475533A1 ES 475533 A1 ES475533 A1 ES 475533A1 ES 475533 A ES475533 A ES 475533A ES 475533 A ES475533 A ES 475533A ES 475533 A1 ES475533 A1 ES 475533A1
- Authority
- ES
- Spain
- Prior art keywords
- novel
- manufacture
- amide derivative
- novel compounds
- parenteral
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- -1 propione amide Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 239000000812 cholinergic antagonist Substances 0.000 abstract 2
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 150000004694 iodide salts Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Un método para la preparación de formas racémicas y ópticamente activas de 2-(4-difenilil)- N-(dimetilamino-alquil)propionamida y sus sales de la fórmula**fórmula** en donde n es 2 o 3 y Et es C2H5 caracterizado porque comprende hacer reaccionar un derivado funcional bajo formas racémicas u ópticamente activas de ácido 2-U4-difenilil) propiónico con N,N-dietil- etilendiamina o N,N-dietil-1,3-propilendiamina, en presencia de un disolvente apropiado, en cuya realización, el derivado funcional del ácido 2-(4-difenilil)propiónico se adiciona lentamente con agitación, a una de las citadas aminas en presencia de un disolvente apropiado y, después de mantener la masa reaccionante bajo reflujo, se concentra y se extrae con agua, de cuya solución acuosa se precipita a continuación el producto con sosa y se cristaliza en un disolvente adecuado.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT964377A IT1090782B (it) | 1977-11-30 | 1977-11-30 | 2 4 bifenilil 2 dietilamino alchil propionamide suoi sali e procedimenti di fabbricazione relativi |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES475533A1 true ES475533A1 (es) | 1980-01-16 |
Family
ID=11132874
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES475533A Expired ES475533A1 (es) | 1977-11-30 | 1978-11-29 | Un metodo para la preparacion de formas racemicas y optica- mente activas de 2-(4-difenilil)-n-(dimetilamino-alquil)pro-pionamida |
Country Status (9)
| Country | Link |
|---|---|
| JP (1) | JPS5490157A (es) |
| BE (1) | BE872403A (es) |
| CA (1) | CA1118446A (es) |
| CH (1) | CH637370A5 (es) |
| DE (1) | DE2851416A1 (es) |
| ES (1) | ES475533A1 (es) |
| FR (1) | FR2410641A1 (es) |
| IT (1) | IT1090782B (es) |
| NL (1) | NL7811698A (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITMI20012025A1 (it) | 2001-09-28 | 2003-03-28 | Dompe Spa | Sali di ammonio quaternari di omega-amminoalchilammidi di acidi r 2-aril-propionici e composizioni farmaceutiche che li contengono |
| US20090221703A1 (en) | 2006-07-09 | 2009-09-03 | Chongxi Yu | High penetration composition and uses thereof |
| US20090238763A1 (en) | 2006-07-09 | 2009-09-24 | Chongxi Yu | High penetration compositions and uses thereof |
| EP2049482B1 (en) * | 2006-08-08 | 2015-10-21 | Techfields Biochem Co. Ltd | Positively charged water-soluble prodrugs of aryl- and heteroarylacetic acids with very fast skin penetration rate |
| AU2013206218B2 (en) * | 2006-08-15 | 2016-06-30 | Techfields Biochem Co. Ltd | Positively charged water-soluble prodrugs of aryl- and heteroarylpropionic acids with very fast skin penetration rate |
| CA2660814C (en) * | 2006-08-15 | 2017-07-18 | Techfields Biochem Co. Ltd | Positively charged water-soluble prodrugs of aryl- and heteroarylpropionic acids with very fast skin penetration rate |
| MX2009013136A (es) | 2007-06-04 | 2010-04-30 | Techfields Inc | Profarmacos de nsaias con piel y membranas con indices de penetracion muy altos y nuevos usos medicinales. |
| CN107261149A (zh) | 2008-12-04 | 2017-10-20 | 于崇曦 | 高穿透性组合物及其应用 |
| JP5940036B2 (ja) * | 2013-10-08 | 2016-06-29 | テックフィールズ バイオケム カンパニー リミテッド | 非常に速い皮膚透過率を有するアリール−及びヘテロアリールプロピオン酸の正荷電水溶性プロドラッグ |
| JP6290947B2 (ja) * | 2016-02-05 | 2018-03-07 | テックフィールズ バイオケム カンパニー リミテッド | 非常に速い皮膚透過率を有するアリール−及びヘテロアリールプロピオン酸の正荷電水溶性プロドラッグ |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1584547A (es) * | 1968-06-05 | 1969-12-26 | ||
| FR1593024A (es) * | 1968-09-18 | 1970-05-25 | ||
| FR2119846A1 (en) * | 1970-12-28 | 1972-08-11 | Choay Sa | N,n-diethylaminoethylamide of para isobutyl phenylacetic - acid - antiinflammatory and analgesic |
| US4145435A (en) * | 1976-11-12 | 1979-03-20 | The Upjohn Company | 2-aminocycloaliphatic amide compounds |
-
1977
- 1977-11-30 IT IT964377A patent/IT1090782B/it active
-
1978
- 1978-11-28 CH CH1216178A patent/CH637370A5/it not_active IP Right Cessation
- 1978-11-28 DE DE19782851416 patent/DE2851416A1/de active Granted
- 1978-11-29 NL NL7811698A patent/NL7811698A/xx not_active Application Discontinuation
- 1978-11-29 ES ES475533A patent/ES475533A1/es not_active Expired
- 1978-11-30 CA CA000317175A patent/CA1118446A/en not_active Expired
- 1978-11-30 BE BE192036A patent/BE872403A/xx not_active IP Right Cessation
- 1978-11-30 JP JP14730778A patent/JPS5490157A/ja active Granted
- 1978-11-30 FR FR7833889A patent/FR2410641A1/fr active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| DE2851416C2 (es) | 1989-02-23 |
| CH637370A5 (en) | 1983-07-29 |
| FR2410641B1 (es) | 1983-04-15 |
| IT1090782B (it) | 1985-06-26 |
| BE872403A (fr) | 1979-03-16 |
| JPS631286B2 (es) | 1988-01-12 |
| DE2851416A1 (de) | 1979-05-31 |
| JPS5490157A (en) | 1979-07-17 |
| CA1118446A (en) | 1982-02-16 |
| FR2410641A1 (fr) | 1979-06-29 |
| NL7811698A (nl) | 1979-06-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19991102 |