ES443626A1 - Arufua 66 deokishitetorasaikurin no seiho - Google Patents
Arufua 66 deokishitetorasaikurin no seihoInfo
- Publication number
- ES443626A1 ES443626A1 ES443626A ES443626A ES443626A1 ES 443626 A1 ES443626 A1 ES 443626A1 ES 443626 A ES443626 A ES 443626A ES 443626 A ES443626 A ES 443626A ES 443626 A1 ES443626 A1 ES 443626A1
- Authority
- ES
- Spain
- Prior art keywords
- group
- hydrogenation
- acid addition
- addition salt
- isomer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000002253 acid Substances 0.000 abstract 2
- 238000005984 hydrogenation reaction Methods 0.000 abstract 2
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000004098 Tetracycline Substances 0.000 abstract 1
- 230000002378 acidificating effect Effects 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 230000003197 catalytic effect Effects 0.000 abstract 1
- 125000004218 chloromethyl group Chemical group [H]C([H])(Cl)* 0.000 abstract 1
- 125000000068 chlorophenyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004772 dichloromethyl group Chemical group [H]C(Cl)(Cl)* 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000007935 neutral effect Effects 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 229960002180 tetracycline Drugs 0.000 abstract 1
- 229930101283 tetracycline Natural products 0.000 abstract 1
- 235000019364 tetracycline Nutrition 0.000 abstract 1
- 150000003522 tetracyclines Chemical class 0.000 abstract 1
- 125000003944 tolyl group Chemical group 0.000 abstract 1
- 125000003866 trichloromethyl group Chemical group ClC(Cl)(Cl)* 0.000 abstract 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
- B01J31/22—Organic complexes
- B01J31/2204—Organic complexes the ligands containing oxygen or sulfur as complexing atoms
- B01J31/2208—Oxygen, e.g. acetylacetonates
- B01J31/2226—Anionic ligands, i.e. the overall ligand carries at least one formal negative charge
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
- B01J31/24—Phosphines, i.e. phosphorus bonded to only carbon atoms, or to both carbon and hydrogen atoms, including e.g. sp2-hybridised phosphorus compounds such as phosphabenzene, phosphole or anionic phospholide ligands
- B01J31/2404—Cyclic ligands, including e.g. non-condensed polycyclic ligands, the phosphine-P atom being a ring member or a substituent on the ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
- C07F15/0073—Rhodium compounds
- C07F15/008—Rhodium compounds without a metal-carbon linkage
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/50—Organo-phosphines
- C07F9/5045—Complexes or chelates of phosphines with metallic compounds or metals
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F41—WEAPONS
- F41A—FUNCTIONAL FEATURES OR DETAILS COMMON TO BOTH SMALLARMS AND ORDNANCE, e.g. CANNONS; MOUNTINGS FOR SMALLARMS OR ORDNANCE
- F41A9/00—Feeding or loading of ammunition; Magazines; Guiding means for the extracting of cartridges
- F41A9/01—Feeding of unbelted ammunition
- F41A9/24—Feeding of unbelted ammunition using a movable magazine or clip as feeding element
- F41A9/26—Feeding of unbelted ammunition using a movable magazine or clip as feeding element using a revolving drum magazine
- F41A9/27—Feeding of unbelted ammunition using a movable magazine or clip as feeding element using a revolving drum magazine in revolver-type guns
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F41—WEAPONS
- F41A—FUNCTIONAL FEATURES OR DETAILS COMMON TO BOTH SMALLARMS AND ORDNANCE, e.g. CANNONS; MOUNTINGS FOR SMALLARMS OR ORDNANCE
- F41A9/00—Feeding or loading of ammunition; Magazines; Guiding means for the extracting of cartridges
- F41A9/29—Feeding of belted ammunition
- F41A9/30—Sprocket-type belt transporters
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2231/00—Catalytic reactions performed with catalysts classified in B01J31/00
- B01J2231/60—Reduction reactions, e.g. hydrogenation
- B01J2231/64—Reductions in general of organic substrates, e.g. hydride reductions or hydrogenations
- B01J2231/641—Hydrogenation of organic substrates, i.e. H2 or H-transfer hydrogenations, e.g. Fischer-Tropsch processes
- B01J2231/645—Hydrogenation of organic substrates, i.e. H2 or H-transfer hydrogenations, e.g. Fischer-Tropsch processes of C=C or C-C triple bonds
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
- B01J2531/80—Complexes comprising metals of Group VIII as the central metal
- B01J2531/82—Metals of the platinum group
- B01J2531/822—Rhodium
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Materials Engineering (AREA)
- Inorganic Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Catalysts (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Improved process of hydrogenating the exocyclic methylene group of a 6-deoxy-6-demotyl-6-methylenthothracycline or an acid addition salt thereof, characterized by carrying out the hydrogenation at a temperature of from about 20º to about 100ºC, at a pressure of from about 1 to about 100 atmospheres, under near neutral conditions or in the weakly acidic tetracycline acid addition salt in the presence of a catalytic amount of a compound of the formula Rh (OCOR) 2 (p [C6H5] 3) wherein R is selected from the group consisting of hydrogen, alkyl having 1 to 6 carbon atoms, chloromethyl, dichloromethyl, trichloromethyl, fluomethyl, difluomethyl, trifluomethyl, phenyl, chlorophenyl, tolyl, and anisyl, whereby the hydrogenation of the group of exocyclic methylene advances with a stereaselectivity that favors the alpha-isomer over the beta-isomer. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US53445274A | 1974-12-19 | 1974-12-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES443626A1 true ES443626A1 (en) | 1977-05-01 |
Family
ID=24130096
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES443626A Expired ES443626A1 (en) | 1974-12-19 | 1975-12-18 | Arufua 66 deokishitetorasaikurin no seiho |
Country Status (26)
| Country | Link |
|---|---|
| JP (1) | JPS5186457A (en) |
| AR (1) | AR208347A1 (en) |
| AT (1) | AT344320B (en) |
| AU (1) | AU476488B2 (en) |
| BE (1) | BE836775A (en) |
| BG (1) | BG24798A3 (en) |
| CH (1) | CH609042A5 (en) |
| CS (1) | CS203099B2 (en) |
| DD (1) | DD123600A5 (en) |
| DE (1) | DE2554564A1 (en) |
| DK (1) | DK151224C (en) |
| ES (1) | ES443626A1 (en) |
| FI (1) | FI59395C (en) |
| FR (1) | FR2295014A1 (en) |
| HU (1) | HU173508B (en) |
| IE (1) | IE42180B1 (en) |
| LU (1) | LU74054A1 (en) |
| NL (1) | NL164849B (en) |
| NO (1) | NO146236C (en) |
| PH (1) | PH13795A (en) |
| PL (1) | PL105946B1 (en) |
| RO (1) | RO72846A (en) |
| SE (1) | SE426587B (en) |
| SU (1) | SU799650A3 (en) |
| YU (1) | YU39474B (en) |
| ZA (1) | ZA757902B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE435619C (en) * | 1973-02-01 | 1985-11-18 | Pfizer | PROCEDURE FOR PREPARING A 6ALFA DEOXYTETRACYCLINE |
| DK386784A (en) * | 1983-08-17 | 1985-02-18 | Hovione Int Ltd | PROCEDURE FOR PREPARING ALFA-6-DESOXY-TETRACYCLINES |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1368431A (en) * | 1970-07-22 | 1974-09-25 | Johnson Matthey Co Ltd | Rhodium complex and methods of preparing the complex |
| SE435619C (en) * | 1973-02-01 | 1985-11-18 | Pfizer | PROCEDURE FOR PREPARING A 6ALFA DEOXYTETRACYCLINE |
-
1975
- 1975-01-01 AR AR261678A patent/AR208347A1/en active
- 1975-11-18 IE IE2514/75A patent/IE42180B1/en unknown
- 1975-11-20 SE SE7513091A patent/SE426587B/en not_active IP Right Cessation
- 1975-12-03 NO NO754085A patent/NO146236C/en unknown
- 1975-12-03 YU YU3050/75A patent/YU39474B/en unknown
- 1975-12-04 DE DE19752554564 patent/DE2554564A1/en active Pending
- 1975-12-04 PH PH17832A patent/PH13795A/en unknown
- 1975-12-09 FI FI753459A patent/FI59395C/en not_active IP Right Cessation
- 1975-12-10 AT AT937675A patent/AT344320B/en not_active IP Right Cessation
- 1975-12-12 JP JP50148315A patent/JPS5186457A/en active Granted
- 1975-12-17 PL PL1975185665A patent/PL105946B1/en unknown
- 1975-12-17 CH CH1636475A patent/CH609042A5/en not_active IP Right Cessation
- 1975-12-18 BE BE1007088A patent/BE836775A/en not_active IP Right Cessation
- 1975-12-18 DK DK576575A patent/DK151224C/en not_active IP Right Cessation
- 1975-12-18 ES ES443626A patent/ES443626A1/en not_active Expired
- 1975-12-18 LU LU74054A patent/LU74054A1/xx unknown
- 1975-12-18 RO RO7584246A patent/RO72846A/en unknown
- 1975-12-18 HU HU74PI502A patent/HU173508B/en not_active IP Right Cessation
- 1975-12-18 AU AU87668/75A patent/AU476488B2/en not_active Expired
- 1975-12-18 SU SU752198555A patent/SU799650A3/en active
- 1975-12-18 ZA ZA00757902A patent/ZA757902B/en unknown
- 1975-12-19 FR FR7539084A patent/FR2295014A1/en active Granted
- 1975-12-19 BG BG031853A patent/BG24798A3/en unknown
- 1975-12-19 NL NL7514840.A patent/NL164849B/en not_active IP Right Cessation
- 1975-12-19 CS CS758721A patent/CS203099B2/en unknown
- 1975-12-19 DD DD190359A patent/DD123600A5/xx unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES382975A1 (en) | Process for reactivating a reforming catalyst | |
| ES443626A1 (en) | Arufua 66 deokishitetorasaikurin no seiho | |
| ES323287A1 (en) | Procedure for preparing substituted pirrolindazol compounds. (Machine-translation by Google Translate, not legally binding) | |
| ES404745A1 (en) | Cephalosporin compounds | |
| ES278356A1 (en) | Procedure for the preparation of substitute hydrazine compounds (Machine-translation by Google Translate, not legally binding) | |
| ES376641A1 (en) | A method to produce a preparation to influence growth of plants. (Machine-translation by Google Translate, not legally binding) | |
| ES407059A1 (en) | Tris-organotin sulfolenes and sulfolanes | |
| ES389350A1 (en) | Method of controlling weeds with organotin compounds | |
| GB1367602A (en) | Process for preparing amino-substituted phosphonates | |
| ES416514A1 (en) | Production of erythromycylamine compounds | |
| ES415114A1 (en) | Process for the production of organotin halides | |
| ES449147A1 (en) | 15 - deutero-prostaglandin derivatives methods for their preparation and compositions containing said derivatives | |
| GB1343470A (en) | Complex compounds of metals belonging to group viii of the periodic table and process for preparaing the same | |
| ES425197A1 (en) | Penicillanic acids their production and their medicinal use | |
| ES419839A1 (en) | Substituted methylene diamines | |
| ES402328A1 (en) | Preparation of 4-hydroxybenzodioxoles | |
| ES434355A1 (en) | Device to vary the width of via, especially of agricultural vehicles. (Machine-translation by Google Translate, not legally binding) | |
| ES329950A1 (en) | A procedure for the preparation of penicillin. (Machine-translation by Google Translate, not legally binding) | |
| ES337700A1 (en) | Procedure for preparing molluscyced agents. (Machine-translation by Google Translate, not legally binding) | |
| ES382794A1 (en) | Nickel compounds | |
| ES252263A1 (en) | Process for preparing derivatives of 7-sulfamyl-6-trifluoromethyl-1, 2, 4-benzothiadazine-1, 1-dioxide | |
| ES287028A1 (en) | Procedure for the manufacture of new basic derivatives of fenoxazine and its salts (Machine-translation by Google Translate, not legally binding) | |
| ES443438A1 (en) | A method for the control of corrosión in an aqueous system. (Machine-translation by Google Translate, not legally binding) | |
| ES355907A3 (en) | Procedure for preparing 3-imino-benzisotiazolinas substituted in the atom of nitrogen. (Machine-translation by Google Translate, not legally binding) | |
| ES394989A1 (en) | Procedure for the preparation of nitrofuran derivatives. (Machine-translation by Google Translate, not legally binding) |