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ES432862A1 - Antibiotic derivatives of xk-62-2 and method of production thereof - Google Patents

Antibiotic derivatives of xk-62-2 and method of production thereof

Info

Publication number
ES432862A1
ES432862A1 ES432862A ES432862A ES432862A1 ES 432862 A1 ES432862 A1 ES 432862A1 ES 432862 A ES432862 A ES 432862A ES 432862 A ES432862 A ES 432862A ES 432862 A1 ES432862 A1 ES 432862A1
Authority
ES
Spain
Prior art keywords
antibiotic
production
formula
image
antibiotic derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES432862A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KH Neochem Co Ltd
Original Assignee
Kyowa Hakko Kogyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Co Ltd filed Critical Kyowa Hakko Kogyo Co Ltd
Publication of ES432862A1 publication Critical patent/ES432862A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
    • C07H15/236—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2 a saccharide radical being substituted by an alkylamino radical in position 3 and by two substituents different from hydrogen in position 4, e.g. gentamicin complex, sisomicin, verdamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Acylation of the antibiotic which is known under the name XK-62-2 and has the formula A < IMAGE > in which R6 is hydrogen with a compound of the formula Y1Y2N-CH2-CH2-CHOH-COZ initially results in a mixture of various acylated compounds from which the required compound with the group < IMAGE > is isolated, and the protective group Y2 is removed before or after the isolation. The antibiotic has a broad spectrum of antibacterial activity, especially against Escherichia coli KY 8327 and 8348.
ES432862A 1973-12-12 1974-12-12 Antibiotic derivatives of xk-62-2 and method of production thereof Expired ES432862A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP13782773A JPS5635193B2 (en) 1973-12-12 1973-12-12

Publications (1)

Publication Number Publication Date
ES432862A1 true ES432862A1 (en) 1977-04-01

Family

ID=15207762

Family Applications (1)

Application Number Title Priority Date Filing Date
ES432862A Expired ES432862A1 (en) 1973-12-12 1974-12-12 Antibiotic derivatives of xk-62-2 and method of production thereof

Country Status (15)

Country Link
JP (1) JPS5635193B2 (en)
AT (1) AT337894B (en)
CA (1) CA1030530A (en)
CH (1) CH618180A5 (en)
DE (1) DE2458921C3 (en)
DK (1) DK644174A (en)
ES (1) ES432862A1 (en)
FR (1) FR2254565B1 (en)
GB (1) GB1470329A (en)
IN (1) IN141068B (en)
NL (1) NL7416211A (en)
NO (1) NO139562C (en)
PH (1) PH15160A (en)
SE (1) SE417825B (en)
ZA (1) ZA747907B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA017824B1 (en) 2007-11-21 2013-03-29 Эйкеоджен, Инк. Antibacterial aminoglycoside analogs
WO2010132768A1 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial derivatives of sisomicin
WO2010132765A2 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial aminoglycoside analogs
WO2010132757A2 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial aminoglycoside analogs
WO2010132759A1 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial derivatives of dibekacin
WO2010132760A1 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial derivatives of tobramycin

Also Published As

Publication number Publication date
PH15160A (en) 1982-08-27
CA1030530A (en) 1978-05-02
NL7416211A (en) 1975-06-16
DE2458921A1 (en) 1975-06-26
JPS5088050A (en) 1975-07-15
SE7415609L (en) 1975-06-13
AU7636074A (en) 1976-06-17
ATA991874A (en) 1976-11-15
NO744447L (en) 1975-07-07
DE2458921C3 (en) 1978-04-06
ZA747907B (en) 1976-01-28
FR2254565A1 (en) 1975-07-11
DK644174A (en) 1975-08-25
NO139562C (en) 1979-04-04
DE2458921B2 (en) 1977-08-04
FR2254565B1 (en) 1979-08-10
GB1470329A (en) 1977-04-14
AT337894B (en) 1977-07-25
SE417825B (en) 1981-04-13
NO139562B (en) 1978-12-27
IN141068B (en) 1977-01-15
CH618180A5 (en) 1980-07-15
JPS5635193B2 (en) 1981-08-15

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