ES434095A1 - Substituted tetrahydrobenzothiophenes - Google Patents
Substituted tetrahydrobenzothiophenesInfo
- Publication number
- ES434095A1 ES434095A1 ES434095A ES434095A ES434095A1 ES 434095 A1 ES434095 A1 ES 434095A1 ES 434095 A ES434095 A ES 434095A ES 434095 A ES434095 A ES 434095A ES 434095 A1 ES434095 A1 ES 434095A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- compound
- nhr1
- radical
- reacting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/116—Heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/116—Heterocyclic compounds
- A23K20/121—Heterocyclic compounds containing oxygen or sulfur as hetero atom
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/116—Heterocyclic compounds
- A23K20/137—Heterocyclic compounds containing two hetero atoms, of which at least one is nitrogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D333/56—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D333/66—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D333/70—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/78—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
- C07D333/80—Seven-membered rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Polymers & Plastics (AREA)
- Engineering & Computer Science (AREA)
- Animal Husbandry (AREA)
- Zoology (AREA)
- Food Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Diabetes (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Fodder In General (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Feed For Specific Animals (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The novel compounds correspond to the formula: < IMAGE > in which X, Y, Z, R1, R2, R3 and U have the meanings given in Claim 1. They are prepared by a) reacting one mol equivalent of a compound of the formula I or II, in which the -NR1-CX-NHR1 radical is replaced, or its acid addition salts with 1 to 1.5 mol equivalents of R2NCX or b) reacting one mol equivalent of an acid addition salt of a compound of the formula I or II, in which R2 and R3 denotes hydrogen and the -NR1-CX-NHR2 radical is replaced by -NHR1, with 1 to 1.5 mol equivalents of a compound of the formula MeNCX, in which Me denotes sodium or potassium, and isolating the product. The reaction (a) is carried out in water or an inert organic solvent at 0 to 100 DEG C. The reaction (b) is carried out in aqueous medium at pH = 5 to 7 and 10 to 80 DEG C. The novel compounds of the formulae I and II are administered orally to warm-blooded animals to improve the extent of the feed effect and to increase the growth rate. A supplementary feed for increasing the growth rate of poultry, fur-bearing animals and agricultural productive animals contains 70 to 99% by weight of an edible carrier and, as the remainder, a novel compound of the formula I or II.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43682674A | 1974-01-25 | 1974-01-25 | |
| US43682774A | 1974-01-25 | 1974-01-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES434095A1 true ES434095A1 (en) | 1977-05-16 |
Family
ID=27031116
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES434095A Expired ES434095A1 (en) | 1974-01-25 | 1975-01-24 | Substituted tetrahydrobenzothiophenes |
Country Status (21)
| Country | Link |
|---|---|
| JP (1) | JPS51125069A (en) |
| AT (1) | AT353590B (en) |
| CA (1) | CA1060899A (en) |
| CH (4) | CH619703A5 (en) |
| CS (1) | CS195276B2 (en) |
| DD (4) | DD125212A5 (en) |
| DE (1) | DE2501788C2 (en) |
| DK (1) | DK22775A (en) |
| ES (1) | ES434095A1 (en) |
| FR (1) | FR2333801A1 (en) |
| GB (1) | GB1499582A (en) |
| IE (1) | IE42039B1 (en) |
| IL (1) | IL46375A (en) |
| IN (1) | IN141050B (en) |
| IT (1) | IT1035548B (en) |
| LU (1) | LU71711A1 (en) |
| NL (1) | NL7500845A (en) |
| PH (1) | PH14544A (en) |
| SE (1) | SE421617B (en) |
| TR (1) | TR18381A (en) |
| YU (1) | YU36721B (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3994924A (en) * | 1975-11-04 | 1976-11-30 | American Cyanamid Company | 4,5,6,7-Tetra hydro-7-oxobenzo(B)thien-4-yl isocyanate and isothiocyanate |
| FR2430231A1 (en) * | 1978-07-04 | 1980-02-01 | American Cyanamid Co | 4,5,6,7-Tetra:hydro-benzo(b)thienyl-4 urea and 7-oxo deriv. compsn. - used for increasing growth of wool and ratio of sec. to prim. follicles in sheep, goats, llamas, rabbits and chinchilla |
| JPS6169772A (en) * | 1984-12-04 | 1986-04-10 | アメリカン サイアナミッド カンパニ− | Tetrahydrobenzo(b)thiophene derivative, manufacture and animal growth acceleration |
| EP1801098A1 (en) | 2005-12-16 | 2007-06-27 | Merck Sante | 2-Adamantylurea derivatives as selective 11B-HSD1 inhibitors |
-
1974
- 1974-12-31 CA CA217,189A patent/CA1060899A/en not_active Expired
-
1975
- 1975-01-01 IL IL46375A patent/IL46375A/en unknown
- 1975-01-02 IN IN20/CAL/75A patent/IN141050B/en unknown
- 1975-01-06 IE IE26/75A patent/IE42039B1/en unknown
- 1975-01-10 PH PH16699A patent/PH14544A/en unknown
- 1975-01-14 GB GB1592/75A patent/GB1499582A/en not_active Expired
- 1975-01-17 DE DE2501788A patent/DE2501788C2/en not_active Expired
- 1975-01-21 AT AT42675A patent/AT353590B/en not_active IP Right Cessation
- 1975-01-22 CS CS75448A patent/CS195276B2/en unknown
- 1975-01-23 FR FR7502174A patent/FR2333801A1/en active Granted
- 1975-01-23 LU LU71711A patent/LU71711A1/xx unknown
- 1975-01-24 IT IT47844/75A patent/IT1035548B/en active
- 1975-01-24 NL NL7500845A patent/NL7500845A/en not_active Application Discontinuation
- 1975-01-24 DD DD192556A patent/DD125212A5/xx unknown
- 1975-01-24 YU YU0172/75A patent/YU36721B/en unknown
- 1975-01-24 DK DK22775*BA patent/DK22775A/da not_active Application Discontinuation
- 1975-01-24 CH CH87775A patent/CH619703A5/en not_active IP Right Cessation
- 1975-01-24 SE SE7500793A patent/SE421617B/en not_active IP Right Cessation
- 1975-01-24 ES ES434095A patent/ES434095A1/en not_active Expired
- 1975-01-24 DD DD183814A patent/DD119790A5/xx unknown
- 1975-01-24 DD DD192557A patent/DD125213A5/xx unknown
- 1975-01-24 DD DD192555A patent/DD125211A5/xx unknown
- 1975-01-25 JP JP50010184A patent/JPS51125069A/en active Granted
- 1975-01-27 TR TR18381A patent/TR18381A/en unknown
-
1978
- 1978-09-29 CH CH1016878A patent/CH619705A5/en not_active IP Right Cessation
- 1978-09-29 CH CH1016678A patent/CH619704A5/en not_active IP Right Cessation
- 1978-09-29 CH CH1016778A patent/CH619949A5/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DK22775A (en) | 1975-09-15 |
| DE2501788C2 (en) | 1984-11-08 |
| JPS6133830B2 (en) | 1986-08-04 |
| PH14544A (en) | 1981-09-24 |
| CH619703A5 (en) | 1980-10-15 |
| IL46375A0 (en) | 1975-04-25 |
| IE42039L (en) | 1975-07-25 |
| CS195276B2 (en) | 1980-01-31 |
| DD119790A5 (en) | 1976-05-12 |
| IL46375A (en) | 1982-04-30 |
| FR2333801B1 (en) | 1982-07-09 |
| SE7500793L (en) | 1975-07-28 |
| DD125211A5 (en) | 1977-04-06 |
| IE42039B1 (en) | 1980-05-21 |
| YU36721B (en) | 1984-08-31 |
| LU71711A1 (en) | 1975-06-24 |
| YU17275A (en) | 1982-06-18 |
| CH619949A5 (en) | 1980-10-31 |
| NL7500845A (en) | 1975-07-29 |
| CA1060899A (en) | 1979-08-21 |
| CH619705A5 (en) | 1980-10-15 |
| DD125213A5 (en) | 1977-04-06 |
| DD125212A5 (en) | 1977-04-06 |
| JPS51125069A (en) | 1976-11-01 |
| SE421617B (en) | 1982-01-18 |
| IN141050B (en) | 1977-01-15 |
| CH619704A5 (en) | 1980-10-15 |
| AT353590B (en) | 1979-11-26 |
| ATA42675A (en) | 1979-04-15 |
| TR18381A (en) | 1977-05-01 |
| DE2501788A1 (en) | 1975-07-31 |
| GB1499582A (en) | 1978-02-01 |
| AU7691574A (en) | 1976-07-01 |
| IT1035548B (en) | 1979-10-20 |
| FR2333801A1 (en) | 1977-07-01 |
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