ES421713A1 - Pregnane acid derivatives - Google Patents
Pregnane acid derivativesInfo
- Publication number
- ES421713A1 ES421713A1 ES421713A ES421713A ES421713A1 ES 421713 A1 ES421713 A1 ES 421713A1 ES 421713 A ES421713 A ES 421713A ES 421713 A ES421713 A ES 421713A ES 421713 A1 ES421713 A1 ES 421713A1
- Authority
- ES
- Spain
- Prior art keywords
- compounds
- acid derivatives
- groups
- free acid
- hydroxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000002253 acid Substances 0.000 title abstract 4
- JWMFYGXQPXQEEM-NUNROCCHSA-N 5β-pregnane Chemical compound C([C@H]1CC2)CCC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H](CC)[C@@]2(C)CC1 JWMFYGXQPXQEEM-NUNROCCHSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- GWZUYOSMTQIJMY-DIKHCDEOSA-N 2-[(8s,9s,10s,13r,14s,17r)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]acetic acid Chemical class C1CCC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)CC(O)=O)[C@@H]4[C@@H]3CCC21 GWZUYOSMTQIJMY-DIKHCDEOSA-N 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 125000003172 aldehyde group Chemical group 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- -1 alkali metal salts Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000004185 ester group Chemical group 0.000 abstract 1
- 229910003439 heavy metal oxide Inorganic materials 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000008177 pharmaceutical agent Substances 0.000 abstract 1
- 150000003126 pregnane derivatives Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/0026—Oxygen-containing hetero ring cyclic ketals
- C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Pregnanoic acid derivatives of the following formula < IMAGE > in which the substituents are defined in Claim 1, are prepared. These compounds are obtained by oxidising a corresponding pregnane derivative which has an aldehyde group in position 21 to the free acid using heavy metal oxides. These acids can be converted into corresponding 21-esters. The said compounds which have a saturated 1,2-bond can be dehydrogenated to DELTA <1,4>-steroids. 11-Hydroxy groups can be oxidised to 11-keto groups the 11-hydroxy group can also be esterified. It is furthermore possible to hydrolyse ester groups and to convert the free acid into the alkali metal salts. The said compounds are valuable pharmaceutical agents and can also be used as intermediates for the preparation of pharmaceuticals.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19722264003 DE2264003C2 (en) | 1972-12-22 | 1972-12-22 | New pregnanic acid derivatives, processes for their production and pharmaceutical preparations containing them |
| DE2360444A DE2360444A1 (en) | 1973-11-30 | 1973-11-30 | Anti-inflammatory pregnan-21-carboxylic acids - are substd 16-alpa-17-alpa-isopropylidene-dioxy 3,20-dioxo-pregn-4-ene and 1,4-diene-21-acid derivs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES421713A1 true ES421713A1 (en) | 1976-04-16 |
Family
ID=25764292
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES421713A Expired ES421713A1 (en) | 1972-12-22 | 1973-12-21 | Pregnane acid derivatives |
Country Status (15)
| Country | Link |
|---|---|
| JP (1) | JPS5912680B2 (en) |
| AR (1) | AR207751A1 (en) |
| AT (1) | AT340072B (en) |
| CA (1) | CA1007221A (en) |
| CH (2) | CH618185A5 (en) |
| DD (1) | DD108290A5 (en) |
| DK (1) | DK135380C (en) |
| ES (1) | ES421713A1 (en) |
| FI (1) | FI52735C (en) |
| FR (1) | FR2211259B1 (en) |
| GB (1) | GB1457264A (en) |
| IE (1) | IE38659B1 (en) |
| IL (1) | IL43881A (en) |
| SE (1) | SE402111B (en) |
| YU (1) | YU35897B (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2451971A1 (en) * | 1974-10-31 | 1976-05-13 | Schering Ag | NEW PREGNAN 21 ACID DERIVATIVES |
| US4257969A (en) * | 1980-01-23 | 1981-03-24 | E. R. Squibb & Sons, Inc. | 16,17-Dihydroxypregnene-21-carboxylic acids and derivatives |
| US5215979A (en) * | 1985-12-19 | 1993-06-01 | Aktiebolaget Draco | 16,17-acetalsubstituted pregnane 21-oic acid derivatives |
| SE8506015D0 (en) * | 1985-12-19 | 1985-12-19 | Draco Ab | NOVEL 16,17-ACETALSUBSTITUTED PREGNANE 21-OIC ACID DERIVATIVES |
| US4897260A (en) * | 1987-05-22 | 1990-01-30 | The Rockefeller University | Compositions that affect suppression of cutaneous delayed hypersensitivity and products including same |
| AP157A (en) * | 1990-04-25 | 1991-11-15 | Richter Gedeon Vegyeszet | Novel steroid derivatives. |
| CN101863952B (en) * | 2010-04-30 | 2013-04-17 | 湖北葛店人福药业有限责任公司 | Preparation method of budesonide |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1387911A (en) * | 1971-10-04 | 1975-03-19 | Schering Ag | Pregnane acid derivatives |
-
1973
- 1973-12-18 IE IE2295/73A patent/IE38659B1/en unknown
- 1973-12-18 DK DK688773A patent/DK135380C/en active
- 1973-12-19 GB GB5877473A patent/GB1457264A/en not_active Expired
- 1973-12-20 FI FI733928A patent/FI52735C/en active
- 1973-12-20 SE SE7317245A patent/SE402111B/en unknown
- 1973-12-21 AR AR251666A patent/AR207751A1/en active
- 1973-12-21 YU YU3323/73A patent/YU35897B/en unknown
- 1973-12-21 ES ES421713A patent/ES421713A1/en not_active Expired
- 1973-12-21 CH CH1807673A patent/CH618185A5/en not_active IP Right Cessation
- 1973-12-21 CA CA188,725A patent/CA1007221A/en not_active Expired
- 1973-12-21 DD DD175620A patent/DD108290A5/xx unknown
- 1973-12-21 AT AT1073973A patent/AT340072B/en active
- 1973-12-21 IL IL43881A patent/IL43881A/en unknown
- 1973-12-22 JP JP744869A patent/JPS5912680B2/en not_active Expired
- 1973-12-26 FR FR7346233A patent/FR2211259B1/fr not_active Expired
-
1978
- 1978-11-03 CH CH1135878A patent/CH618447A5/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AT340072B (en) | 1977-11-25 |
| IE38659L (en) | 1974-06-22 |
| DK135380C (en) | 1977-10-03 |
| JPS4994660A (en) | 1974-09-09 |
| YU332373A (en) | 1981-02-28 |
| SE402111B (en) | 1978-06-19 |
| DK135380B (en) | 1977-04-18 |
| CA1007221A (en) | 1977-03-22 |
| YU35897B (en) | 1981-08-31 |
| CH618447A5 (en) | 1980-07-31 |
| FR2211259A1 (en) | 1974-07-19 |
| ATA1073973A (en) | 1977-03-15 |
| CH618185A5 (en) | 1980-07-15 |
| FR2211259B1 (en) | 1976-09-03 |
| JPS5912680B2 (en) | 1984-03-24 |
| IE38659B1 (en) | 1978-05-10 |
| FI52735C (en) | 1977-11-10 |
| IL43881A (en) | 1976-12-31 |
| DD108290A5 (en) | 1974-09-12 |
| IL43881A0 (en) | 1974-06-30 |
| FI52735B (en) | 1977-08-01 |
| GB1457264A (en) | 1976-12-01 |
| AR207751A1 (en) | 1976-10-29 |
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