ES428132A1 - Alkylated pregnanes - Google Patents

Abstract

Procedure for the preparation of new alcoholized spheroids from the pregnane series that have the formula **(See formula)** where I = H or halogen, Y = H2, H (OH), H (Oacil), 0 or H (halogen), R1 = alcohol group having 1-4 C atoms, R2 = R1 or H, R3 = H, CH3 or halogen, Z = OH, Oalcohilo or Oaoilo, or forms, together with R4, a group as indicated below, Q = (when C15-C16 is saturated) alcoholidene having 1-4 O atoms or (betaH) (alpha-R4), where R4, together with Z, is alcoholidenedioxy having 3-5 C atoms, alcoholidene having 1-4 C atoms, aralcohilidene having 7-8 C atoms, alcohol of the formula (see formula), where A = H or halogen and B = H, halogen, alcohol (1-4 C), haloalkoxy, alkoxy or phenyl, or a group [17alpha, 16alpha-d] - or [16alpha, 17alpha-d ] -oxazolino, where the C atom in position 2'can be substituted by alcoholic (1-4 C) or phenyl; or Q = (when C15-C16 is unsaturated) methyl or halomethyl, comprising (a) from a compound having the partial formula **(See formula)** where R1 and R2 have the meanings given above, and introducing the required substituents at positions 15,16 and/or 17 of the final products by methods known per se, or (b) monoalkohilar in 21 or dialkohilar in 21,21 compounds 20 -ceto of the pregnant series that have the partial formula **(See formula)** where Z and Q have the meanings given above and R5 = H or halogen, and then introduce the required substituents where necessary in the final products and which are not yet present, by methods known per se. (Machine-translation by Google Translate, not legally binding)