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ES403124A1 - Procedure for obtaining an antibacterial composition. (Machine-translation by Google Translate, not legally binding) - Google Patents

Procedure for obtaining an antibacterial composition. (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES403124A1
ES403124A1 ES403124A ES403124A ES403124A1 ES 403124 A1 ES403124 A1 ES 403124A1 ES 403124 A ES403124 A ES 403124A ES 403124 A ES403124 A ES 403124A ES 403124 A1 ES403124 A1 ES 403124A1
Authority
ES
Spain
Prior art keywords
translation
procedure
obtaining
machine
legally binding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES403124A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE2025414A external-priority patent/DE2025414C3/en
Priority claimed from DE19712104580 external-priority patent/DE2104580C3/en
Application filed by Bayer AG filed Critical Bayer AG
Publication of ES403124A1 publication Critical patent/ES403124A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/21—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D499/44—Compounds with an amino radical acylated by carboxylic acids, attached in position 6
    • C07D499/48—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical
    • C07D499/58—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical
    • C07D499/64—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical by nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/30—Oxygen or sulfur atoms
    • C07D233/32—One oxygen atom
    • C07D233/38—One oxygen atom with acyl radicals or hetero atoms directly attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/21—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D499/44—Compounds with an amino radical acylated by carboxylic acids, attached in position 6
    • C07D499/48—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical
    • C07D499/58—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical
    • C07D499/64—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical by nitrogen atoms
    • C07D499/68—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical by nitrogen atoms with aromatic rings as additional substituents on the carbon chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Procedure for obtaining an antibacterial composition, characterized in that in a first stage a penicillin of general formula I is prepared: **(See formula)** where R represents phenyl and R'and R''represent methyl, and whose compounds, as regards the center of chirality (see formula) can be presented in the two possible configurations R and S and as mixtures of the resulting diastereomers, as well as the pharmaceutically tolerable non-toxic salts of these compounds, reacting a compound of general formula II: **(See formula)** where R is defined as above, with a compound of the general formula: **(See formula)** where R'and R''are defined as above and W represents halogen or azido, the reaction being carried out in anhydrous or aqueous solvents, in the presence of a base; and in a second step, the resulting penicillin is mixed with a pharmaceutically acceptable vehicle. (Machine-translation by Google Translate, not legally binding)
ES403124A 1970-05-25 1972-05-24 Procedure for obtaining an antibacterial composition. (Machine-translation by Google Translate, not legally binding) Expired ES403124A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE2025414A DE2025414C3 (en) 1970-05-25 1970-05-25 Cyclic acylureidophenylacetamidopenicillanic acids
DE19712104580 DE2104580C3 (en) 1971-02-01 1971-02-01 Acylureidopenicillins

Publications (1)

Publication Number Publication Date
ES403124A1 true ES403124A1 (en) 1976-01-01

Family

ID=25759178

Family Applications (4)

Application Number Title Priority Date Filing Date
ES391532A Expired ES391532A1 (en) 1970-05-25 1971-05-25 Procedure for the obtaining of penicillines. (Machine-translation by Google Translate, not legally binding)
ES403125A Expired ES403125A1 (en) 1970-05-25 1972-05-24 Procedure for obtaining an antibacterial composition. (Machine-translation by Google Translate, not legally binding)
ES403124A Expired ES403124A1 (en) 1970-05-25 1972-05-24 Procedure for obtaining an antibacterial composition. (Machine-translation by Google Translate, not legally binding)
ES403126A Expired ES403126A1 (en) 1970-05-25 1972-05-24 Procedure for obtaining an antibacterial composition. (Machine-translation by Google Translate, not legally binding)

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES391532A Expired ES391532A1 (en) 1970-05-25 1971-05-25 Procedure for the obtaining of penicillines. (Machine-translation by Google Translate, not legally binding)
ES403125A Expired ES403125A1 (en) 1970-05-25 1972-05-24 Procedure for obtaining an antibacterial composition. (Machine-translation by Google Translate, not legally binding)

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES403126A Expired ES403126A1 (en) 1970-05-25 1972-05-24 Procedure for obtaining an antibacterial composition. (Machine-translation by Google Translate, not legally binding)

Country Status (28)

Country Link
JP (1) JPS5538357B1 (en)
AR (2) AR195267A1 (en)
AT (1) AT307617B (en)
BE (1) BE767647A (en)
BG (1) BG23220A3 (en)
CA (1) CA943128A (en)
CH (1) CH562249A5 (en)
CS (1) CS171230B2 (en)
CY (1) CY829A (en)
DD (1) DD91497B3 (en)
DK (1) DK133679C (en)
EG (1) EG10856A (en)
ES (4) ES391532A1 (en)
FI (1) FI54484C (en)
FR (1) FR2100681B1 (en)
GB (1) GB1301961A (en)
HU (1) HU162205B (en)
IE (1) IE35311B1 (en)
IL (1) IL36905A (en)
KE (1) KE2592A (en)
LU (1) LU63203A1 (en)
NL (1) NL172660C (en)
NO (1) NO141164C (en)
PH (1) PH14794A (en)
RO (2) RO62689A (en)
SE (1) SE395896B (en)
SU (1) SU472507A3 (en)
YU (1) YU130271A (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2354219A1 (en) * 1973-10-30 1975-05-07 Bayer Ag BETA-LACTAM-ANTIBIOTICA, A PROCESS FOR THEIR MANUFACTURING AND ITS USE AS A MEDICINAL PRODUCT
US4039673A (en) 1973-10-30 1977-08-02 Bayer Aktiengesellschaft Penicillins and cephalosporins and their production
GB1486349A (en) * 1974-11-28 1977-09-21 Bayer Ag Beta-lactam antibiotics process for their preparation and their use as medicaments
DE2658906A1 (en) * 1976-12-24 1978-07-06 Bayer Ag BETA-LACTAM ANTIBIOTICS, THE METHOD OF MANUFACTURING AND THEIR USE AS A MEDICINAL PRODUCT
GB1584400A (en) * 1976-12-24 1981-02-11 Bayer Ag (2-oxo-imidazoliden-1-yl(carbonylamino)-acetamido-cephalosporins and penicillins
CA1133896A (en) * 1978-05-26 1982-10-19 Nobuhiro Oi Penicillanic acid derivative and process for preparing the same
JPS5732289A (en) 1980-08-05 1982-02-20 Chugai Pharmaceut Co Ltd Alpha-substituted ureidobenzylpenicillin

Also Published As

Publication number Publication date
YU130271A (en) 1982-02-25
LU63203A1 (en) 1971-09-01
NO141164B (en) 1979-10-15
BE767647A (en) 1971-11-25
ES403125A1 (en) 1975-12-16
RO62689A (en) 1978-05-15
AR195946A1 (en) 1973-11-15
RO59157A (en) 1976-04-15
IE35311B1 (en) 1976-01-07
DD91497A5 (en) 1972-07-20
HU162205B (en) 1973-01-29
FI54484B (en) 1978-08-31
AT307617B (en) 1973-05-25
SE395896B (en) 1977-08-29
BG23220A3 (en) 1977-07-12
NL7107175A (en) 1971-11-29
EG10856A (en) 1977-05-31
NO141164C (en) 1980-01-23
FR2100681B1 (en) 1974-10-18
CH562249A5 (en) 1975-05-30
KE2592A (en) 1976-01-09
SU472507A3 (en) 1975-05-30
JPS5538357B1 (en) 1980-10-03
IL36905A0 (en) 1971-07-28
FI54484C (en) 1978-12-11
CS171230B2 (en) 1976-10-29
IE35311L (en) 1971-11-25
DK133679C (en) 1976-11-15
AR195267A1 (en) 1973-09-28
NL172660B (en) 1983-05-02
DD91497B3 (en) 1988-01-27
DK133679B (en) 1976-06-28
IL36905A (en) 1975-11-25
CY829A (en) 1976-03-19
GB1301961A (en) 1973-01-04
FR2100681A1 (en) 1972-03-24
CA943128A (en) 1974-03-05
PH14794A (en) 1981-12-09
NL172660C (en) 1983-10-03
ES403126A1 (en) 1975-05-01
ES391532A1 (en) 1974-10-01

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19910211