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ES406767A1 - Procedure for the preparation of new indol derivatives. (Machine-translation by Google Translate, not legally binding) - Google Patents

Procedure for the preparation of new indol derivatives. (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES406767A1
ES406767A1 ES406767A ES406767A ES406767A1 ES 406767 A1 ES406767 A1 ES 406767A1 ES 406767 A ES406767 A ES 406767A ES 406767 A ES406767 A ES 406767A ES 406767 A1 ES406767 A1 ES 406767A1
Authority
ES
Spain
Prior art keywords
general formula
translation
procedure
preparation
lower alcohol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES406767A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novo Terapeutisk Laboratorium AS
Original Assignee
Novo Terapeutisk Laboratorium AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Terapeutisk Laboratorium AS filed Critical Novo Terapeutisk Laboratorium AS
Publication of ES406767A1 publication Critical patent/ES406767A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/36—Oxygen atoms in position 3, e.g. adrenochrome

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Procedure for the preparation of new indole derivatives of the general formula I ** (See formula) ** wherein X and Y, independently of one another, represent hydrogen, halogen, lower alcohol or lower alkoxy; R1 signifies hydrogen or R4, where R4 is lower alcohol or lower aralcohyl; R2 signifies hydrogen, lower alcohol, lower aralcohyl or aryl; R3 represents lower alcohol or both its substituents R3 together with the nitrogen atom attached to them, form a pyrrolidine or piperidine ring, and A is an alcohol chain with 2 or 3 carbon atoms, and of acid addition salts of these derivatives with physiologically tolerable acids, characterized in that an indole derivative of the general formula II is subjected to deacetylation ** (See formula) ** wherein X, Y, A, R2 and R3 are as defined above, in the presence of a base such as ammonia or an alkali metal alkoxylate, after which the indole derivative of general formula I formed from this mode in which R1 is a hydrogen atom, when desired, in an indole derivative of the general formula I where R1 has the meanings of the above, and the compound of the general formula I prepared, is transformed, when desired, in an acid addition salt with a physiologically tolerable acid. (Machine-translation by Google Translate, not legally binding)
ES406767A 1969-05-27 1972-09-16 Procedure for the preparation of new indol derivatives. (Machine-translation by Google Translate, not legally binding) Expired ES406767A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB2668369 1969-05-27

Publications (1)

Publication Number Publication Date
ES406767A1 true ES406767A1 (en) 1975-10-01

Family

ID=10247535

Family Applications (3)

Application Number Title Priority Date Filing Date
ES380057A Expired ES380057A1 (en) 1969-05-27 1970-05-26 Procedure for the preparation of new indol derivatives. (Machine-translation by Google Translate, not legally binding)
ES406768A Expired ES406768A1 (en) 1969-05-27 1972-09-16 Procedure for the preparation of new indol derivatives. (Machine-translation by Google Translate, not legally binding)
ES406767A Expired ES406767A1 (en) 1969-05-27 1972-09-16 Procedure for the preparation of new indol derivatives. (Machine-translation by Google Translate, not legally binding)

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES380057A Expired ES380057A1 (en) 1969-05-27 1970-05-26 Procedure for the preparation of new indol derivatives. (Machine-translation by Google Translate, not legally binding)
ES406768A Expired ES406768A1 (en) 1969-05-27 1972-09-16 Procedure for the preparation of new indol derivatives. (Machine-translation by Google Translate, not legally binding)

Country Status (11)

Country Link
AT (3) AT307410B (en)
AU (1) AU1535270A (en)
BE (1) BE750943A (en)
CA (1) CA966137A (en)
CH (1) CH556840A (en)
DE (2) DE2024966A1 (en)
ES (3) ES380057A1 (en)
FR (1) FR2051562B1 (en)
GB (1) GB1306230A (en)
NL (1) NL7007646A (en)
ZA (1) ZA703363B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9416972D0 (en) * 1994-08-23 1994-10-12 Smithkline Beecham Plc Carbon side chain/indole/indolene
WO2004048331A1 (en) * 2002-11-28 2004-06-10 Suven Life Sciences Limited N-arylalkyl-3-aminoalkoxyindoles and their use as 5-ht ligands
EP1567492B1 (en) * 2002-11-28 2013-05-22 Suven Life Sciences Limited N-arylsulfonyl-3-aminoalkoxyindoles

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2395370A (en) * 1970-12-31 1972-07-06 Novo Terapeutisk Laboratorium A/S Improvements in or relating to indole derivatives

Also Published As

Publication number Publication date
CA966137A (en) 1975-04-15
DE2065321A1 (en) 1973-05-24
FR2051562B1 (en) 1974-07-12
AT307410B (en) 1973-05-25
AT312596B (en) 1974-01-10
ES406768A1 (en) 1975-10-01
BE750943A (en) 1970-11-26
FR2051562A1 (en) 1971-04-09
ZA703363B (en) 1971-12-29
AT315830B (en) 1974-06-10
ES380057A1 (en) 1973-04-16
CH556840A (en) 1974-12-13
DE2024966A1 (en) 1970-12-03
AU1535270A (en) 1971-11-25
NL7007646A (en) 1970-12-01
GB1306230A (en) 1973-02-07

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