ES387410A1 - Pyridoxine mono-esters - Google Patents
Pyridoxine mono-estersInfo
- Publication number
- ES387410A1 ES387410A1 ES387410A ES387410A ES387410A1 ES 387410 A1 ES387410 A1 ES 387410A1 ES 387410 A ES387410 A ES 387410A ES 387410 A ES387410 A ES 387410A ES 387410 A1 ES387410 A1 ES 387410A1
- Authority
- ES
- Spain
- Prior art keywords
- compound
- alcohol
- radical
- formula
- see formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/65—One oxygen atom attached in position 3 or 5
- C07D213/66—One oxygen atom attached in position 3 or 5 having in position 3 an oxygen atom and in each of the positions 4 and 5 a carbon atom bound to an oxygen, sulphur, or nitrogen atom, e.g. pyridoxal
- C07D213/67—2-Methyl-3-hydroxy-4,5-bis(hydroxy-methyl)pyridine, i.e. pyridoxine
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A method of preparing new pyridoxine monoester salts having the general formula ** (See formula) ** wherein A and A1 each represent an alcoholic radical with a chain of up to 16 carbon atoms or an amino-hydrocarbon radical, for example an amino-alcohol radical such as (see formula) or (see formula) where R represents a hydrogen atom or a CH3CO group, where p is 1 or 2; R1 and R2 each represent an alcohol radical containing up to 5 carbon atoms, said radicals being separated, or forming with the nitrogen atom a heterocyclic ring; Ac represents a pharmaceutically acceptable acid, and n is an integer that takes the value 1, 2 or 3, which consists of blocking the two alcohol functions at positions 3- and 4-, then reacting the compound thus obtained with the compound of the formula ClCO-A-COO-A1-NR1R2, in which A, A1, R1 and R2 have the same meanings given above, then undo, in the new compound thus obtained, the blocking of the two alcohol functions in the positions 3- and 4-, and finally treating it with the selected acid to obtain the corresponding pharmaceutically acceptable acid addition salt. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB289970 | 1970-01-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES387410A1 true ES387410A1 (en) | 1973-05-16 |
Family
ID=9748130
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES387410A Expired ES387410A1 (en) | 1970-01-21 | 1971-01-19 | Pyridoxine mono-esters |
Country Status (11)
| Country | Link |
|---|---|
| JP (1) | JPS4822712B1 (en) |
| AT (1) | AT303729B (en) |
| BE (1) | BE761534A (en) |
| CA (1) | CA969958A (en) |
| CH (1) | CH518281A (en) |
| ES (1) | ES387410A1 (en) |
| FR (2) | FR2081444B1 (en) |
| GB (1) | GB1286161A (en) |
| NL (1) | NL142332B (en) |
| OA (1) | OA03677A (en) |
| ZA (1) | ZA708588B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL187159A0 (en) | 2007-07-03 | 2009-02-11 | Gur Megiddo | Use of metadoxine in relief of alcohol intoxication |
| EP2323735A1 (en) | 2008-07-29 | 2011-05-25 | Alcobra Ltd. | Substituted pyridoxine-lactam carboxylate salts |
| EP2445498A1 (en) * | 2009-06-25 | 2012-05-02 | Alcobra Ltd. | A method for the treatment, alleviation of symptoms of, relieving, improving and preventing a cognitive disease, disorder or condition |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR3735E (en) * | 1904-08-22 | 1905-02-21 | Jean Fayaud | Coverage of running trains and repetition of signals on the machine |
-
1970
- 1970-01-21 GB GB42153/70A patent/GB1286161A/en not_active Expired
- 1970-12-21 ZA ZA708588A patent/ZA708588B/en unknown
- 1970-12-31 JP JP45123806A patent/JPS4822712B1/ja active Pending
-
1971
- 1971-01-12 CH CH45571A patent/CH518281A/en not_active IP Right Cessation
- 1971-01-12 FR FR7100717A patent/FR2081444B1/fr not_active Expired
- 1971-01-13 BE BE761534A patent/BE761534A/en not_active IP Right Cessation
- 1971-01-18 OA OA54143A patent/OA03677A/en unknown
- 1971-01-19 AT AT43671A patent/AT303729B/en not_active IP Right Cessation
- 1971-01-19 ES ES387410A patent/ES387410A1/en not_active Expired
- 1971-01-20 NL NL717100756A patent/NL142332B/en not_active IP Right Cessation
- 1971-01-21 CA CA103,470A patent/CA969958A/en not_active Expired
-
1972
- 1972-09-06 FR FR7231500A patent/FR2154465B1/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| NL7100756A (en) | 1971-07-23 |
| ZA708588B (en) | 1971-09-29 |
| OA03677A (en) | 1971-12-24 |
| FR2081444B1 (en) | 1974-09-27 |
| FR2081444A1 (en) | 1971-12-03 |
| CA969958A (en) | 1975-06-24 |
| DE2102831A1 (en) | 1971-07-22 |
| AT303729B (en) | 1972-12-11 |
| FR2154465A1 (en) | 1973-05-11 |
| GB1286161A (en) | 1972-08-23 |
| BE761534A (en) | 1971-07-13 |
| NL142332B (en) | 1974-06-17 |
| JPS4822712B1 (en) | 1973-07-07 |
| DE2102831B2 (en) | 1975-10-09 |
| CH518281A (en) | 1972-01-31 |
| FR2154465B1 (en) | 1975-08-08 |
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