ES358401A1 - A procedure for the preparation of new esters of alpha-aminobencil-penicillin. (Machine-translation by Google Translate, not legally binding)
- Google Patents
A procedure for the preparation of new esters of alpha-aminobencil-penicillin. (Machine-translation by Google Translate, not legally binding)
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Leo Pharma AS
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Leo Pharmaceutical Products Ltd AS
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Priority claimed from GB4453567Aexternal-prioritypatent/GB1215812A/en
Application filed by Leo Pharmaceutical Products Ltd ASfiledCriticalLeo Pharmaceutical Products Ltd AS
Publication of ES358401A1publicationCriticalpatent/ES358401A1/en
Organic Low-Molecular-Weight Compounds And Preparation Thereof
(AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Abstract
A procedure for the preparation of new α-aminobenzylpenicillin esters of the general formula **(See formula)** where the asterisk indicates an asymmetric carbon atom; n is an integer from 0 to 5; and A is an unsubstituted or substituted aliphatic, alicyclic, aromatic or heterocyclic radical, and salts of these esters with pharmaceutically acceptable acids, consisting of reacting an α-R-substituted benzylpenicillin or a salt thereof of the formula (II) **(See formula)** where R is an amino group or a substituted amino group or a group which can be converted to an amino group, and Y is hydrogen or a cation, with a compound of formula (III) X-CH2-OCO (CH2) n-A (III) where X is a halogen atom, an acyloxy, alkylsulfonyloxy or arylsulfonyloxy radical, and n and A are as defined above, obtaining the compound of formula (I) in the case where R is an amino group, and obtaining a compound of formula (IV) in the case where R is a substituted amino group or a group which can be converted to an amino group: **(See formula)** where R, 11 and A have the same meanings as indicated above, while the substituent R of this intermediate is converted to an amino group. (Machine-translation by Google Translate, not legally binding)
ES358401A1967-09-291968-09-21A procedure for the preparation of new esters of alpha-aminobencil-penicillin. (Machine-translation by Google Translate, not legally binding)
ExpiredES358401A1
(en)
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