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ES263335A1 - Phenylcyclopropyl amides - Google Patents

Phenylcyclopropyl amides

Info

Publication number
ES263335A1
ES263335A1 ES0263335A ES263335A ES263335A1 ES 263335 A1 ES263335 A1 ES 263335A1 ES 0263335 A ES0263335 A ES 0263335A ES 263335 A ES263335 A ES 263335A ES 263335 A1 ES263335 A1 ES 263335A1
Authority
ES
Spain
Prior art keywords
lower alkyl
amino
nitrogen
substituted
mercapto
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES0263335A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LAKESIDE LAB Inc
Original Assignee
LAKESIDE LAB Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by LAKESIDE LAB Inc filed Critical LAKESIDE LAB Inc
Publication of ES263335A1 publication Critical patent/ES263335A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D207/28—2-Pyrrolidone-5- carboxylic acids; Functional derivatives thereof, e.g. esters, nitriles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention comprises compounds of general formula: <FORM:0961313/C1/1> wherein R is hydrogen, lower (1-8C) alkyl, lower alkenyl, phenyl-lower alkyl, nuclear substituted phenyl-lower alkyl, cycloalkyl, cycloalkyl-lower alkyl, hydroxy-lower alkyl, halo-lower alkyl, dicyclic hydroxy methyl, mono- or di-amino-lower alkyl, (halophenoxy)-lower alkyl, (mercapto)-(amino)-substituted lower alkyl, (alkyl-mercapto)-(amino)-substituted lower alkyl, (hydroxy)-(amino)-substituted lower alkyl, o -carboxy-(amino)-lower alkyl, a nitrogen-containing heterocyclyl group, an o -(nitrogen-containing heterocyclyl)-(amino)-lower alkyl group, or an o -(nitrogen-containing heterocyclyl)-lower alkyl group trans isomers are preferred: and the process of reacting a compound of formula: <FORM:0961313/C1/2> with a compound of formula: <FORM:0961313/C1/3> in the presence of dicyclohexylcarbodiimide to yield a product of formula: <FORM:0961313/C1/4> wherein R1 is mono- or di-amino-lower alkyl, (mercapto)-(amino), substituted lower alkyl, (alkyl-mercapto)-(amino)-substituted lower alkyl, (hydroxy)-(amino)-substituted lower alkyl, an o -carboxy-(amino)-lower alkyl group, a nitrogen-containing heterocyclyl group, or an o -(nitrogen-containing-heterocyclyl) - (amino) - lower alkyl group. Other processes exemplified use as starting material acid halides which are reacted with the phenylcyclopropylamine N-(trans-2-phenylcyclopropyl)-2-piperidino-acetamide is prepared by reacting the chloroacetamide with piperidine. Pharmaceutical compositions are mentioned which comprise compounds I together with suitable carriers for administration to humans and animals. Oral administration and solid (tablets, capsules) and liquid carriers are mentioned. The compounds inhibit monoamine oxidase and are used in depression, angina pectoris and arthritis.
ES0263335A 1960-02-26 1960-12-17 Phenylcyclopropyl amides Expired ES263335A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US1114260A 1960-02-26 1960-02-26

Publications (1)

Publication Number Publication Date
ES263335A1 true ES263335A1 (en) 1961-04-16

Family

ID=21749061

Family Applications (1)

Application Number Title Priority Date Filing Date
ES0263335A Expired ES263335A1 (en) 1960-02-26 1960-12-17 Phenylcyclopropyl amides

Country Status (5)

Country Link
DE (1) DE1234728B (en)
DK (1) DK110096C (en)
ES (1) ES263335A1 (en)
FR (1) FR1445453A (en)
GB (1) GB961313A (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3954777A (en) * 1970-03-03 1976-05-04 Zambon S.P.A. Aminopropionyl derivatives of 2,3-diphenyl cyclopropylamine
US3954778A (en) * 1970-03-03 1976-05-04 Zambon S.P.A. Aminoacetyl derivatives of 2,3-diphenyl cyclopropyl amine

Also Published As

Publication number Publication date
DK110096C (en) 1968-11-04
GB961313A (en) 1964-06-17
FR1445453A (en) 1966-07-15
DE1234728B (en) 1967-02-23

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