ES261748A1 - Procedimiento para el cultivo de un organismo productor de actinoespectacina - Google Patents
Procedimiento para el cultivo de un organismo productor de actinoespectacinaInfo
- Publication number
- ES261748A1 ES261748A1 ES0261748A ES261748A ES261748A1 ES 261748 A1 ES261748 A1 ES 261748A1 ES 0261748 A ES0261748 A ES 0261748A ES 261748 A ES261748 A ES 261748A ES 261748 A1 ES261748 A1 ES 261748A1
- Authority
- ES
- Spain
- Prior art keywords
- spectacin
- actino
- antibiotic
- water
- salts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- UNFWWIHTNXNPBV-UHFFFAOYSA-N Actinospectacin Natural products O1C2C(O)C(NC)C(O)C(NC)C2OC2(O)C1OC(C)CC2=O UNFWWIHTNXNPBV-UHFFFAOYSA-N 0.000 title abstract 9
- 229960000268 spectinomycin Drugs 0.000 title abstract 9
- UNFWWIHTNXNPBV-WXKVUWSESA-N spectinomycin Chemical compound O([C@@H]1[C@@H](NC)[C@@H](O)[C@H]([C@@H]([C@H]1O1)O)NC)[C@]2(O)[C@H]1O[C@H](C)CC2=O UNFWWIHTNXNPBV-WXKVUWSESA-N 0.000 title abstract 9
- 238000000034 method Methods 0.000 title abstract 2
- 230000003115 biocidal effect Effects 0.000 abstract 6
- 150000003839 salts Chemical class 0.000 abstract 6
- 239000002253 acid Substances 0.000 abstract 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 4
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract 3
- 235000015097 nutrients Nutrition 0.000 abstract 3
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 abstract 2
- XPCTZQVDEJYUGT-UHFFFAOYSA-N 3-hydroxy-2-methyl-4-pyrone Chemical compound CC=1OC=CC(=O)C=1O XPCTZQVDEJYUGT-UHFFFAOYSA-N 0.000 abstract 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 2
- 241000124008 Mammalia Species 0.000 abstract 2
- 241000970875 Streptomyces spectabilis Species 0.000 abstract 2
- 150000007513 acids Chemical class 0.000 abstract 2
- 239000003242 anti bacterial agent Substances 0.000 abstract 2
- 229940088710 antibiotic agent Drugs 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 239000003729 cation exchange resin Substances 0.000 abstract 2
- 238000000855 fermentation Methods 0.000 abstract 2
- 230000004151 fermentation Effects 0.000 abstract 2
- 239000012458 free base Substances 0.000 abstract 2
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical compound C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 abstract 2
- 239000011347 resin Substances 0.000 abstract 2
- 229920005989 resin Polymers 0.000 abstract 2
- 239000002904 solvent Substances 0.000 abstract 2
- 238000001179 sorption measurement Methods 0.000 abstract 2
- FIWMVLLHAGLHAY-UHFFFAOYSA-N 3-hydroxy-5-methyl-2-[2,4,6-trihydroxy-3,5-bis(methylamino)cyclohexyl]oxyoxolane-3-carboxylic acid Chemical compound OC1C(NC)C(O)C(NC)C(O)C1OC1C(C(O)=O)(O)CC(C)O1 FIWMVLLHAGLHAY-UHFFFAOYSA-N 0.000 abstract 1
- QRJMLIPXTTYRMQ-SYJWXDLUSA-N Actinamine Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](NC)[C@H]1O QRJMLIPXTTYRMQ-SYJWXDLUSA-N 0.000 abstract 1
- HYMLWHLQFGRFIY-UHFFFAOYSA-N Maltol Natural products CC1OC=CC(=O)C1=O HYMLWHLQFGRFIY-UHFFFAOYSA-N 0.000 abstract 1
- 241000786363 Rhampholeon spectrum Species 0.000 abstract 1
- 229930184317 Streptovaricin Natural products 0.000 abstract 1
- 241001342522 Vampyrum spectrum Species 0.000 abstract 1
- 238000005903 acid hydrolysis reaction Methods 0.000 abstract 1
- 230000002730 additional effect Effects 0.000 abstract 1
- 239000003463 adsorbent Substances 0.000 abstract 1
- 239000003513 alkali Substances 0.000 abstract 1
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 abstract 1
- 239000003957 anion exchange resin Substances 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 230000003385 bacteriostatic effect Effects 0.000 abstract 1
- 239000002585 base Substances 0.000 abstract 1
- 235000013405 beer Nutrition 0.000 abstract 1
- JDECNKBYILMOLE-CJQFIEQYSA-N chembl1255887 Chemical compound O1COC(=C(C)C2=O)C3=C1\C(C)=C\[C@@](C)(O)[C@H](O)[C@@H](C)[C@@H](O)[C@H](C(=O)OC)[C@H](O)[C@H](C)[C@H](O)[C@H](C)\C=C/C=C(C)/C(=O)NC1=C(C)C(OC(C)=O)=C3C2=C1O JDECNKBYILMOLE-CJQFIEQYSA-N 0.000 abstract 1
- RXKJFZQQPQGTFL-UHFFFAOYSA-N dihydroxyacetone Chemical compound OCC(=O)CO RXKJFZQQPQGTFL-UHFFFAOYSA-N 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003651 drinking water Substances 0.000 abstract 1
- 235000020188 drinking water Nutrition 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000004744 fabric Substances 0.000 abstract 1
- 239000006052 feed supplement Substances 0.000 abstract 1
- 238000001914 filtration Methods 0.000 abstract 1
- 238000002347 injection Methods 0.000 abstract 1
- 239000007924 injection Substances 0.000 abstract 1
- 229910052500 inorganic mineral Inorganic materials 0.000 abstract 1
- 229940043353 maltol Drugs 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000002844 melting Methods 0.000 abstract 1
- 230000008018 melting Effects 0.000 abstract 1
- 125000000250 methylamino group Chemical group [H]N(*)C([H])([H])[H] 0.000 abstract 1
- 239000011707 mineral Substances 0.000 abstract 1
- 230000003472 neutralizing effect Effects 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 229910017464 nitrogen compound Inorganic materials 0.000 abstract 1
- 150000002830 nitrogen compounds Chemical class 0.000 abstract 1
- 238000005192 partition Methods 0.000 abstract 1
- 230000008707 rearrangement Effects 0.000 abstract 1
- 238000001953 recrystallisation Methods 0.000 abstract 1
- -1 with hydrochloric Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/886—Streptomyces
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Procedimiento para el cultivo de un organismo productor de actinoespectacina, caracterizado porque el cultivo se realiza en un medio acuoso nutriente, bajo condiciones aeróbicas, hasta que se imparte a dicho medio una actividad sustancial de actinoespectacina, por la producción de la actinoespectacina, y por aislar la actinoespectacina del medio de cultivo.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US847092A US3234092A (en) | 1959-10-20 | 1959-10-20 | Actinospectacin and process for producing same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES261748A1 true ES261748A1 (es) | 1961-02-01 |
Family
ID=25299744
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES0261748A Expired ES261748A1 (es) | 1959-10-20 | 1960-10-18 | Procedimiento para el cultivo de un organismo productor de actinoespectacina |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US3234092A (es) |
| CH (1) | CH370197A (es) |
| DE (1) | DE1181860B (es) |
| DK (1) | DK103717C (es) |
| ES (1) | ES261748A1 (es) |
| FR (1) | FR880M (es) |
| GB (1) | GB959675A (es) |
| SE (1) | SE368150B (es) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3482023A (en) * | 1964-10-15 | 1969-12-02 | Upjohn Co | Process for treating coccidiosis with dihydroactinospectacin |
| US3819485A (en) * | 1972-07-03 | 1974-06-25 | Abbott Lab | Process for producing spectinomycin |
| US4203903A (en) * | 1979-05-10 | 1980-05-20 | The Upjohn Company | Process for the recovery of spectinomycin |
| US4459417A (en) * | 1981-10-16 | 1984-07-10 | The Upjohn Company | Process for preparing spectinomycin analogs: N-demethylation of spectinomycin or its analogs and realkylation of the intermediates |
| US4465848A (en) * | 1981-10-23 | 1984-08-14 | The Upjohn Company | Spectinomycin compounds |
| US4532336A (en) * | 1982-03-19 | 1985-07-30 | The Upjohn Company | 6'-Alkylspectinomycins |
| US4542227A (en) * | 1982-05-24 | 1985-09-17 | The Upjohn Company | Processes for the preparation of spectinomycin analogs, novel products and intermediates therein |
| US4698436A (en) * | 1982-05-24 | 1987-10-06 | The Upjohn Company | Processes for the preparation of spectinomycin analogs, novel products and intermediates therein |
| US4523022A (en) * | 1983-07-07 | 1985-06-11 | The Upjohn Company | Analogs of the antibiotic spectinomycin |
| US4603212A (en) * | 1983-10-18 | 1986-07-29 | The Upjohn Company | Analogs of the antibiotic spectinomycin |
| US4578485A (en) * | 1984-02-08 | 1986-03-25 | The Upjohn Company | Synthesis of spectinomycin analogs by an improved Grignard process |
| DE3671840D1 (de) * | 1985-03-29 | 1990-07-19 | Upjohn Co | Behandlung von chlamydia-infektionen mit spectinomycin-analogen. |
| US4730059A (en) * | 1986-03-10 | 1988-03-08 | The Upjohn Company | 6'-thiomethylsubstituted spectinomycins |
| US5556879A (en) * | 1995-03-01 | 1996-09-17 | Rhone Merieux, Inc. | Aqueous spectinomycin borate solutions |
| DE102007001198B4 (de) * | 2007-01-05 | 2021-02-11 | Bela-Pharm Gmbh & Co Kg | Verfahren zur Verminderung von Anomeren des Spectinomycin |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB811757A (en) * | 1955-11-09 | 1959-04-08 | Upjohn Co | Production of an antibiotic designated antibiotic 101a fermentation |
-
1959
- 1959-10-20 US US847092A patent/US3234092A/en not_active Expired - Lifetime
-
1960
- 1960-08-24 GB GB29265/60D patent/GB959675A/en not_active Expired
- 1960-10-08 DE DEU7500A patent/DE1181860B/de active Pending
- 1960-10-18 ES ES0261748A patent/ES261748A1/es not_active Expired
- 1960-10-19 CH CH1175860A patent/CH370197A/de unknown
- 1960-10-19 SE SE00758/67A patent/SE368150B/xx unknown
- 1960-10-19 DK DK411960AA patent/DK103717C/da active
-
1961
- 1961-01-18 FR FR849998A patent/FR880M/fr active Active
Also Published As
| Publication number | Publication date |
|---|---|
| GB959675A (en) | 1964-06-03 |
| SE368150B (es) | 1974-06-24 |
| DK103717C (da) | 1966-02-14 |
| DE1181860B (de) | 1964-11-19 |
| US3234092A (en) | 1966-02-08 |
| CH370197A (de) | 1963-06-30 |
| FR880M (es) | 1961-10-23 |
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