ES2500292T3 - Camsilato de amlodipina amorfo, estable, procedimiento para la reparación del mismo y composición para su administración oral - Google Patents
Camsilato de amlodipina amorfo, estable, procedimiento para la reparación del mismo y composición para su administración oral Download PDFInfo
- Publication number
- ES2500292T3 ES2500292T3 ES04705547.0T ES04705547T ES2500292T3 ES 2500292 T3 ES2500292 T3 ES 2500292T3 ES 04705547 T ES04705547 T ES 04705547T ES 2500292 T3 ES2500292 T3 ES 2500292T3
- Authority
- ES
- Spain
- Prior art keywords
- camsilate
- stable
- composition
- oral administration
- repair procedure
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- UXKMFEPPKJZDAR-STOWLHSFSA-N [(1r,4s)-7,7-dimethyl-3-oxo-4-bicyclo[2.2.1]heptanyl]methanesulfonic acid;3-o-ethyl 5-o-methyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate Chemical compound C1C[C@@]2(CS(O)(=O)=O)C(=O)C[C@@H]1C2(C)C.CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1Cl UXKMFEPPKJZDAR-STOWLHSFSA-N 0.000 title abstract 2
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 3
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 abstract 3
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 abstract 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 abstract 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 abstract 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 abstract 2
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 abstract 1
- XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 abstract 1
- KXKVLQRXCPHEJC-UHFFFAOYSA-N acetic acid trimethyl ester Natural products COC(C)=O KXKVLQRXCPHEJC-UHFFFAOYSA-N 0.000 abstract 1
- HTIQEAQVCYTUBX-UHFFFAOYSA-N amlodipine Chemical compound CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1Cl HTIQEAQVCYTUBX-UHFFFAOYSA-N 0.000 abstract 1
- 229960000528 amlodipine Drugs 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- E—FIXED CONSTRUCTIONS
- E06—DOORS, WINDOWS, SHUTTERS, OR ROLLER BLINDS IN GENERAL; LADDERS
- E06B—FIXED OR MOVABLE CLOSURES FOR OPENINGS IN BUILDINGS, VEHICLES, FENCES OR LIKE ENCLOSURES IN GENERAL, e.g. DOORS, WINDOWS, BLINDS, GATES
- E06B5/00—Doors, windows, or like closures for special purposes; Border constructions therefor
- E06B5/10—Doors, windows, or like closures for special purposes; Border constructions therefor for protection against air-raid or other war-like action; for other protective purposes
- E06B5/16—Fireproof doors or similar closures; Adaptations of fixed constructions therefor
- E06B5/161—Profile members therefor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2255/00—Coating on the layer surface
- B32B2255/08—Coating on the layer surface on wood layer
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2307/00—Properties of the layers or laminate
- B32B2307/30—Properties of the layers or laminate having particular thermal properties
- B32B2307/306—Resistant to heat
- B32B2307/3065—Flame resistant or retardant, fire resistant or retardant
-
- E—FIXED CONSTRUCTIONS
- E05—LOCKS; KEYS; WINDOW OR DOOR FITTINGS; SAFES
- E05Y—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES E05D AND E05F, RELATING TO CONSTRUCTION ELEMENTS, ELECTRIC CONTROL, POWER SUPPLY, POWER SIGNAL OR TRANSMISSION, USER INTERFACES, MOUNTING OR COUPLING, DETAILS, ACCESSORIES, AUXILIARY OPERATIONS NOT OTHERWISE PROVIDED FOR, APPLICATION THEREOF
- E05Y2900/00—Application of doors, windows, wings or fittings thereof
- E05Y2900/10—Application of doors, windows, wings or fittings thereof for buildings or parts thereof
- E05Y2900/13—Type of wing
- E05Y2900/132—Doors
- E05Y2900/134—Fire doors
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Heart & Thoracic Surgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Cardiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Civil Engineering (AREA)
- Structural Engineering (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
Camsilato de amlodipina amorfo, preparado por disolución de camsilato de amlodipina cristalino en un disolvente orgánico seleccionado entre el grupo que comprende acetona, metanol, etanol, acetonitrilo, tetrahidrofurano, dioxano, acetato de metilo, acetato de etilo, cloruro de metileno, cloroformo y una mezcla de los mismos, y eliminando el disolvente de la solución resultante.
Description
Claims (1)
-
imagen1
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR2003005227 | 2003-01-27 | ||
KR20030005227 | 2003-01-27 | ||
PCT/KR2004/000136 WO2004067512A1 (en) | 2003-01-27 | 2004-01-27 | Stable amorphous amlodipine camsylate, process for preparing same and composition for oral administration thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2500292T3 true ES2500292T3 (es) | 2014-09-30 |
Family
ID=36147033
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES04705547.0T Expired - Lifetime ES2500292T3 (es) | 2003-01-27 | 2004-01-27 | Camsilato de amlodipina amorfo, estable, procedimiento para la reparación del mismo y composición para su administración oral |
Country Status (9)
Country | Link |
---|---|
US (1) | US20060128763A1 (es) |
EP (1) | EP1587792B1 (es) |
JP (1) | JP2007528349A (es) |
KR (1) | KR100558505B1 (es) |
CN (1) | CN1777586A (es) |
BR (1) | BRPI0407038A (es) |
ES (1) | ES2500292T3 (es) |
MX (1) | MXPA05007876A (es) |
WO (1) | WO2004067512A1 (es) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100742432B1 (ko) * | 2005-12-27 | 2007-07-24 | 한미약품 주식회사 | 암로디핀 캠실레이트 및 심바스타틴을 포함하는 복합제제,및 이의 제조방법 |
KR100913791B1 (ko) * | 2006-07-21 | 2009-08-26 | 한미약품 주식회사 | (s)-(-)-암로디핀 캠실레이트 또는 이의 수화물 및 이를함유하는 약학적 조성물 |
KR100821688B1 (ko) | 2006-08-10 | 2008-04-11 | (주)유케이케미팜 | 암로디핀 라셈화물의 입체이성질체의 분리방법과 그의친수성 약물 및 그의 제조방법 |
KR101247583B1 (ko) * | 2006-12-08 | 2013-03-26 | 한미사이언스 주식회사 | 암로디핀 또는 이의 약제학적 허용가능한 염, 및 로자탄또는 이의 약제학적 허용가능한 염을 함유하는 약제학적조성물 |
MX349221B (es) | 2009-01-23 | 2017-07-19 | Hanmi Science Co Ltd * | Composicion farmaceutica solida que comprende amlodipina y losartan y procesos para producir la misma. |
EP3039011A1 (en) * | 2013-08-29 | 2016-07-06 | Cadila Healthcare Limited | Polymorphic form of pyrrole derivative and intermediate thereof |
JP6339364B2 (ja) * | 2013-12-27 | 2018-06-06 | カズマパートナーズ株式会社 | 無定形ブリモニジン酒石酸塩及びその製造方法 |
CN116332832A (zh) * | 2023-03-29 | 2023-06-27 | 安徽美致诚药业有限公司 | 一种马来酸左旋氨氯地平无定型晶型及其制备方法 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8608335D0 (en) | 1986-04-04 | 1986-05-08 | Pfizer Ltd | Pharmaceutically acceptable salts |
KR950007228B1 (ko) | 1987-08-05 | 1995-07-07 | 화이자 인코포레이티드 | 암로디핀의 베실레이트염 |
KR100363566B1 (ko) * | 1998-11-20 | 2003-08-19 | 국제약품공업주식회사 | 무정형 세푸록심 악세틸의 제조방법 |
EP1309557B9 (en) * | 2000-12-29 | 2006-11-15 | Pfizer Limited | Amlodipine hemimaleate |
CZ20031779A3 (cs) * | 2000-12-29 | 2004-10-13 | Bioorganicsáb@V | Způsob přípravy amlodipinuŹ jeho derivátů a jejich prekurzorů |
WO2002053538A1 (en) * | 2000-12-29 | 2002-07-11 | Pfizer Limited | Amlodipine fumarate |
DE10112764A1 (de) * | 2001-03-16 | 2002-09-19 | Mann & Hummel Filter | Radialverdichter |
KR100452491B1 (ko) * | 2001-03-29 | 2004-10-12 | 한미약품 주식회사 | 신규한 결정형 암로디핀 캠실레이트 염 및 그의 제조방법 |
AR037565A1 (es) * | 2001-11-21 | 2004-11-17 | Synthon Bv | Formas de sales de amlodipina y procedimientos para prepararlas. |
-
2004
- 2004-01-27 US US10/543,358 patent/US20060128763A1/en not_active Abandoned
- 2004-01-27 WO PCT/KR2004/000136 patent/WO2004067512A1/en active Search and Examination
- 2004-01-27 KR KR1020040005089A patent/KR100558505B1/ko active IP Right Grant
- 2004-01-27 MX MXPA05007876A patent/MXPA05007876A/es active IP Right Grant
- 2004-01-27 CN CNA200480002970XA patent/CN1777586A/zh active Pending
- 2004-01-27 ES ES04705547.0T patent/ES2500292T3/es not_active Expired - Lifetime
- 2004-01-27 EP EP04705547.0A patent/EP1587792B1/en not_active Expired - Lifetime
- 2004-01-27 JP JP2006502689A patent/JP2007528349A/ja active Pending
- 2004-01-27 BR BR0407038-0A patent/BRPI0407038A/pt not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
BRPI0407038A (pt) | 2006-01-17 |
WO2004067512A1 (en) | 2004-08-12 |
US20060128763A1 (en) | 2006-06-15 |
EP1587792A4 (en) | 2011-03-09 |
EP1587792A1 (en) | 2005-10-26 |
CN1777586A (zh) | 2006-05-24 |
KR20040068877A (ko) | 2004-08-02 |
MXPA05007876A (es) | 2005-09-21 |
JP2007528349A (ja) | 2007-10-11 |
KR100558505B1 (ko) | 2006-03-07 |
EP1587792B1 (en) | 2014-08-27 |
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