[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

ES2548764T3 - Agonistas de cannabinoides de bencimidazol - Google Patents

Agonistas de cannabinoides de bencimidazol Download PDF

Info

Publication number
ES2548764T3
ES2548764T3 ES08718169.9T ES08718169T ES2548764T3 ES 2548764 T3 ES2548764 T3 ES 2548764T3 ES 08718169 T ES08718169 T ES 08718169T ES 2548764 T3 ES2548764 T3 ES 2548764T3
Authority
ES
Spain
Prior art keywords
4alkyl
4alkyloxy
polyhalo
amino
hydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES08718169.9T
Other languages
English (en)
Inventor
Henricus Jacobus Maria Gijsen
Michel Anna Jozef De Cleyn
Michel Surkyn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Original Assignee
Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Application granted granted Critical
Publication of ES2548764T3 publication Critical patent/ES2548764T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Dermatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Compuesto de fórmula (I) incluida cualquier forma estereoquímicamente isomérica del mismo, en donde n es un número entero 0, 1 ó 2; X es SO, SO2 o N-(CO)-R1; R1 es hidrógeno; alquilo C1-6; alquiloxi C1-6; alquiloxi C1-4-alquiloC1-4; o polihalo-alquilo C1-6; R2 es alquilo C1-6; R3 es hidrógeno, halo, alquilo C1-4, alquiloxi C1-4, trifluorometilo o ciano; R4 es alquilo C1-8; alquilo C1-8 sustituido con cicloalquilo C3-8; polihalo-alquilo C1-8; alquilo C1-8 sustituido con 1, 2 ó 3 sustituyentes seleccionados, cada uno independientemente, de hidroxi, alquiloxi C1-4, polihalo-alquiloxi C1-4, ciano, nitro, tetrahidropiranilo, tetrahidrofuranilo, oxetanilo, arilo o heteroarilo; cicloalquilo C3-8; cicloalquilo C3-8 sustituido con 1, 2 ó 3 sustituyentes seleccionados, cada uno independientemente, de hidroxi, alquiloxi C1-4, polihalo-alquiloxi C1-4, ciano, nitro, tetrahidropiranilo, tetrahidrofuranilo, oxetanilo, arilo o heteroarilo; tetrahidropiranilo, tetrahidrofuranilo, oxetanilo, arilo; o heteroarilo; arilo es fenilo; o fenilo sustituido con 1, 2 ó 3 sustituyentes seleccionados, cada uno independientemente, de halo, hidroxi, alquilo C1-4, polihalo-alquilo C1-4, alquiloxi C1-4, polihalo-alquiloxi C1-4, ciano, nitro, NR5R6, R7- carbonilo, R7-SO2-, o alquilo C1-4 sustituido con hidroxi, NR5R6, R7-carbonilo o R7-SO2-; heteroarilo se selecciona de furanilo, tiofenilo, pirrolilo, pirazolilo, imidazolilo, isoxazolilo, tiazolilo, triazolilo, tetrazolilo, isotiazolilo, tiadiazolilo, oxadiazolilo, piridinilo, piridazinilo, pirimidinilo o pirazinilo; en donde R5 y R6 se seleccionan, independientemente de otro, de hidrógeno, alquilo C1-4, polihalo-alquilo C1-4, aminosulfonilo o alquil C1-8-sulfonilo; o R7 carbonilo; en donde R5 y R6, tomados junto con el átomo de nitrógeno que porta R5 y R6, pueden formar un anillo pirrolidinilo, piperidinilo, piperazinilo o morfolinilo; y en donde R7 es alquilo C1-4, hidroxi, amino, amino, mono- o di-(alquil C1-4)amino, (hidroxi-alquil C1-4)amino, (alquiloxi C1-4,-alquil C1-4)amino, di-(alquil C1-4)amino-alquilo C1-4, pirrolidinilo, piperidinilo, morfolinilo, o N-metil-piperazinilo; o una sal por adición de ácidos farmacéuticamente aceptable del mismo, o un solvato del mismo.
ES08718169.9T 2007-03-30 2008-03-25 Agonistas de cannabinoides de bencimidazol Active ES2548764T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP07105286 2007-03-30
EP07105286 2007-03-30
PCT/EP2008/053480 WO2008119694A1 (en) 2007-03-30 2008-03-25 Benzimidazole cannabinoid agonists

Publications (1)

Publication Number Publication Date
ES2548764T3 true ES2548764T3 (es) 2015-10-20

Family

ID=38121987

Family Applications (1)

Application Number Title Priority Date Filing Date
ES08718169.9T Active ES2548764T3 (es) 2007-03-30 2008-03-25 Agonistas de cannabinoides de bencimidazol

Country Status (10)

Country Link
US (1) US8193369B2 (es)
EP (1) EP2142531B1 (es)
JP (1) JP5504153B2 (es)
CN (1) CN101679355B (es)
AR (1) AR065872A1 (es)
CL (1) CL2008000906A1 (es)
ES (1) ES2548764T3 (es)
PA (1) PA8773601A1 (es)
TW (1) TW200901980A (es)
WO (1) WO2008119694A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5816883B2 (ja) 2009-01-22 2015-11-18 ラクオリア創薬株式会社 Ｃｂ２受容体作動活性を有するｎ−置換飽和ヘテロ環スルホン化合物
JP5746698B2 (ja) 2009-08-28 2015-07-08 アリーナ ファーマシューティカルズ， インコーポレイテッド カンナビノイド受容体モジュレーター
KR102036932B1 (ko) 2011-02-25 2019-10-25 아레나 파마슈티칼스, 인크. 축합 아자사이클 (칸나비노이드 수용체 조절제)의 결정질 형태 및 제조 방법
WO2012116279A1 (en) 2011-02-25 2012-08-30 Arena Pharmaceuticals, Inc. Cannabinoid receptor modulators
WO2012116277A1 (en) 2011-02-25 2012-08-30 Arena Pharmaceuticals, Inc. Cannabinoid receptor modulators
WO2015081188A1 (en) * 2013-11-27 2015-06-04 Olatec Industries Llc Pharmaceutical composition comprising omega-(arylsulfonyl)alkylnitrile
WO2022128050A1 (en) 2020-12-14 2022-06-23 Symrise Ag Medicament for fighting inflammation and pain

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0302572D0 (sv) * 2003-09-26 2003-09-26 Astrazeneca Ab Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof
BRPI0517925A (pt) * 2004-11-02 2008-10-21 Pfizer derivados de sulfonil benzimidazol
TW200745096A (en) * 2005-08-23 2007-12-16 Organon Nv Indole derivatives
CN101621998B (zh) * 2006-07-04 2013-12-18 詹森药业有限公司 具有取代的杂环基团的苯并咪唑大麻素激动剂

Also Published As

Publication number Publication date
PA8773601A1 (es) 2008-11-19
JP2010523482A (ja) 2010-07-15
US8193369B2 (en) 2012-06-05
CL2008000906A1 (es) 2008-10-03
CN101679355B (zh) 2014-01-29
JP5504153B2 (ja) 2014-05-28
WO2008119694A1 (en) 2008-10-09
EP2142531A1 (en) 2010-01-13
US20100041702A1 (en) 2010-02-18
EP2142531B1 (en) 2015-07-08
AR065872A1 (es) 2009-07-08
TW200901980A (en) 2009-01-16
CN101679355A (zh) 2010-03-24

Similar Documents

Publication Publication Date Title
ES2548764T3 (es) Agonistas de cannabinoides de bencimidazol
HK1128086A1 (en) Cyclic anilino-pyridinotriazines as gsk-3 inhibitors
AR085153A1 (es) Composiciones pesticidas y procesos relacionados
CO6160266A2 (es) Derivado de oxopirazina y herbicida
ES2571327T3 (es) Composiciones plaguicidas
WO2008156174A1 (ja) ピラジンアミド化合物
RS52168B (en) PIPERIDINSKI GPCR AGONIST
ES2601518T3 (es) Composiciones plaguicidas
PE20091974A1 (es) Derivados de indazoles sustituidos con fenil o piridinilo
CO6150179A2 (es) Derivados de n-(amino-heteroaril)-1h-hindol-2-carboxamidas su preparacion y su aplicacion en terapeutica
AR060545A1 (es) Compuestos de benzoaxol y benzotiazol 6-0- sustituidos y metodos de inhibicion de la senalizacion de csf-1r. composiciones farmaceuticas
NO20092279L (no) Makrocyklisk factor VIIa inhibitorer anvendbare som antikoagulanter
MX2018013152A (es) Composicion fungicida o bactericida y metodo para controlar enfermedades.
UY29844A1 (es) Formulación en aerosol para la inhalación de beta-agonistas
NO20082629L (no) Macrocyklisk factor VIIa-inhibitorer anvendbare som antikoagulanter
NI200800247A (es) Derivados de 1,2,4,5-tetrahidro-3h-benzazepinas, su procedimiento de preparacion y las composiciones farmacéuticas que las contienen.
NO20021294L (no) Benzopyranderivat
MX2009012377A (es) Compuestos de arilamida pirimidona.
AR094123A1 (es) Compuesto triciclicos
AR083147A1 (es) Composicion pesticida y su uso
MX2009012383A (es) Derivados de arilamida pirimidona para el tratamiento de enfermedades neurodegenerativas.
JP2016500653A5 (es)
MX2009003051A (es) Derivados de quinolinona.
AR082962A1 (es) Derivados de quinoxalina y composiciones farmaceuticas
AR062113A1 (es) Derivados de eteres heterociclicos sustituidos,composiciones farmaceuticas que los contienen y usos en trastornos del cns.