ES2125325T3 - Derivados de 4-fenil-3-(heteroarilureido)-1,2-dihidro-2-oxoquinolina como agentes antihipercolesterolemicos y antiateroscleroticos. - Google Patents
Derivados de 4-fenil-3-(heteroarilureido)-1,2-dihidro-2-oxoquinolina como agentes antihipercolesterolemicos y antiateroscleroticos.Info
- Publication number
- ES2125325T3 ES2125325T3 ES93901257T ES93901257T ES2125325T3 ES 2125325 T3 ES2125325 T3 ES 2125325T3 ES 93901257 T ES93901257 T ES 93901257T ES 93901257 T ES93901257 T ES 93901257T ES 2125325 T3 ES2125325 T3 ES 2125325T3
- Authority
- ES
- Spain
- Prior art keywords
- formula
- nitrogen
- group
- compounds
- optionally substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Quinoline Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
LOS COMPONENTES DE LA FORMULA (I) EN DONDE CADA M ES INDEPENDIENTEMENTE SELECCIONADO DE 0 A 4: R2 ES SELECCIONADO DE HIDROGENO Y ALQUIL (C1-C6); CADA R3 Y R4 SON INDEPENDIENTEMENTE SELECCIONADOS DE HALOGENO, ALQUIL (C1-C6) OPCIONALMENTE SUSTITUIDOS CON UNO O MAS ATOMOS DE HALOGENO, ALCOXI (C1-C6) OPCIONALMENTE SUSTITUIDOS CON UNO O MAS ATOMOS DE HALOGENO, ALQUILTIO (C1-C6) OPCIONALMENTE SUSTITUIDO CON UNO O MAS ATOMOS DE HALOGENO; NITRO, CARBOXIL OPCIONALMENTE ESTERIFICADO CON UN GRUPO ALQUIL (C1-C6); HIDROXIL, ACILOXI (C1-C6) Y ACIL (C1-C6); X ES AZUFRE U OXIGENO; Q ES UN GRUPO DE LA FORMULA (XIV), (XV) O (XVI) EN DONDE M ES COMO SE DEFINIO ANTES; N ES 0 O 1. CADA L ESTA INDEPENDIENTEMENTE SELECCIONADO DE 0 A 3; CADA R6 Y R7 ESTAN DEFINIDOS EN LA DESCRIPCION; B,D,E Y G SON SELECCIONADOS DEL GRUPO QUE CONSTA DE NITROGENO Y CARBONO, CON LA PREVISION DE QUE UNO O MAS DE B,D Y E SEAN NITROGENO, Y CON LA PREVISION DE QUE CUANDO G ES NITROGENO, EL GRUPO XVI ESTE UNIDO AL NITROGENO DE LA FORMULA(I) EN LA POSICION 4 O 5 DEL ANILLO PIRIMIDINA (DESIGNADO POR A Y B) EN DONDE CUALQUIERA DE DICHOS NITROGENOS DEBE SER OXIDIZADO, O LAS SALES DE ELLO ACEPTABLES FARMACEUTICAMENTE, Y LOS INTERMEDIARIOS QUE TIENE LA FORMULA (IV) USADA EN LA SINTESIS DE TALES COMPONENTES. LOS COMPONENTES LA FORMULA (I) SON INHIBIDORES DE LA COENZIMA ACIL A: ACILTRANSFERASA DE COLESTEROL (ACAT) Y SON UTILES COMO AGENTES HIPOLIPIDEMICAS Y ANTIARTEROESCLEROSIS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US82463992A | 1992-01-23 | 1992-01-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2125325T3 true ES2125325T3 (es) | 1999-03-01 |
Family
ID=25241935
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES93901257T Expired - Lifetime ES2125325T3 (es) | 1992-01-23 | 1992-12-21 | Derivados de 4-fenil-3-(heteroarilureido)-1,2-dihidro-2-oxoquinolina como agentes antihipercolesterolemicos y antiateroscleroticos. |
Country Status (16)
| Country | Link |
|---|---|
| EP (1) | EP0623112B1 (es) |
| JP (1) | JP2668163B2 (es) |
| KR (1) | KR950700284A (es) |
| AT (1) | ATE175196T1 (es) |
| AU (1) | AU3323393A (es) |
| CA (1) | CA2128093C (es) |
| DE (1) | DE69228069T2 (es) |
| DK (1) | DK0623112T3 (es) |
| ES (1) | ES2125325T3 (es) |
| FI (2) | FI930264A (es) |
| HU (1) | HUT63625A (es) |
| IL (1) | IL104420A0 (es) |
| MX (1) | MX9300361A (es) |
| NO (1) | NO942757D0 (es) |
| WO (1) | WO1993015058A1 (es) |
| ZA (1) | ZA93482B (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6133326A (en) * | 1994-08-31 | 2000-10-17 | Pfizer Inc | Compositions and methods for decreasing sebum production |
| WO1999043659A1 (fr) * | 1998-02-25 | 1999-09-02 | Sumitomo Pharmaceuticals Co., Ltd. | Derives de pyridone et leur procede de fabrication |
| US6452008B2 (en) | 1998-02-25 | 2002-09-17 | Sumitomo Pharmaceuticals Company, Limited | Pyridone derivatives and process for preparing the same |
| CN1398182A (zh) | 2000-02-02 | 2003-02-19 | 沃尼尔·朗伯公司 | 用于皮脂腺疾病的胆甾醇酯和蜡酯合成的双重抑制剂 |
| US8309562B2 (en) | 2003-07-03 | 2012-11-13 | Myrexis, Inc. | Compounds and therapeutical use thereof |
| AU2005279050A1 (en) * | 2004-07-30 | 2006-03-09 | Centre National De La Recherche Scientifique (Cnrs) | Hybrid molecules QA where Q is an aminoquinoline and A is an antibiotic residue, and the synthesis and uses thereof as antibacterial agents |
| FR2874922A1 (fr) * | 2004-07-30 | 2006-03-10 | Palumed Sa | Molecules hybrides qa ou q est une aminoquinoleine et a est un residu antibiotique, leur synthese et leurs utilisations en tant qu'agent antibacterien |
| US8258145B2 (en) | 2005-01-03 | 2012-09-04 | Myrexis, Inc. | Method of treating brain cancer |
| EP1833482A4 (en) | 2005-01-03 | 2011-02-16 | Myriad Genetics Inc | COMPOUNDS AND ITS THERAPEUTIC USE |
| US11618751B1 (en) | 2022-03-25 | 2023-04-04 | Ventus Therapeutics U.S., Inc. | Pyrido-[3,4-d]pyridazine amine derivatives useful as NLRP3 derivatives |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE892088L (en) * | 1988-07-12 | 1990-01-12 | William Henry Deryk Morris | Quinoline derivatives, their production and use |
| MX22406A (es) * | 1989-09-15 | 1994-01-31 | Pfizer | Nuevos derivados de n-aril y n-heteroarilamidas y urea como inhibidores de acil coenzima a: acil transferasa del colesterol (acat). |
| TW205037B (es) * | 1989-10-06 | 1993-05-01 | Takeda Pharm Industry Co Ltd | |
| EP0514546B1 (en) * | 1990-02-10 | 1995-01-04 | Takeda Chemical Industries, Ltd. | Chromene derivatives, their production and use |
| AU1879792A (en) * | 1991-04-26 | 1992-12-21 | Pfizer Inc. | 4-aryl-3-(heteroarylureido)quinoline derivatives |
-
1992
- 1992-12-21 ES ES93901257T patent/ES2125325T3/es not_active Expired - Lifetime
- 1992-12-21 CA CA002128093A patent/CA2128093C/en not_active Expired - Fee Related
- 1992-12-21 WO PCT/US1992/010886 patent/WO1993015058A1/en active IP Right Grant
- 1992-12-21 DK DK93901257T patent/DK0623112T3/da active
- 1992-12-21 AT AT93901257T patent/ATE175196T1/de not_active IP Right Cessation
- 1992-12-21 AU AU33233/93A patent/AU3323393A/en not_active Abandoned
- 1992-12-21 DE DE69228069T patent/DE69228069T2/de not_active Expired - Fee Related
- 1992-12-21 EP EP93901257A patent/EP0623112B1/en not_active Expired - Lifetime
- 1992-12-21 JP JP5513207A patent/JP2668163B2/ja not_active Expired - Fee Related
-
1993
- 1993-01-18 IL IL104420A patent/IL104420A0/xx unknown
- 1993-01-22 MX MX9300361A patent/MX9300361A/es unknown
- 1993-01-22 HU HU9300197A patent/HUT63625A/hu unknown
- 1993-01-22 ZA ZA93482A patent/ZA93482B/xx unknown
- 1993-01-22 FI FI930264A patent/FI930264A/fi unknown
-
1994
- 1994-07-22 KR KR1019940702519A patent/KR950700284A/ko not_active Application Discontinuation
- 1994-07-22 NO NO942757A patent/NO942757D0/no unknown
-
2001
- 2001-01-12 FI FI20010074A patent/FI20010074A/fi unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2128093C (en) | 1998-02-03 |
| DE69228069T2 (de) | 1999-05-20 |
| ATE175196T1 (de) | 1999-01-15 |
| NO942757L (no) | 1994-07-22 |
| KR950700284A (ko) | 1995-01-16 |
| FI930264A0 (fi) | 1993-01-22 |
| JPH07503712A (ja) | 1995-04-20 |
| DK0623112T3 (da) | 1999-08-30 |
| FI20010074A (fi) | 2001-01-12 |
| DE69228069D1 (de) | 1999-02-11 |
| CA2128093A1 (en) | 1993-08-05 |
| AU3323393A (en) | 1993-09-01 |
| WO1993015058A1 (en) | 1993-08-05 |
| HUT63625A (en) | 1993-09-28 |
| MX9300361A (es) | 1994-06-30 |
| EP0623112B1 (en) | 1998-12-30 |
| EP0623112A1 (en) | 1994-11-09 |
| JP2668163B2 (ja) | 1997-10-27 |
| NO942757D0 (no) | 1994-07-22 |
| HU9300197D0 (en) | 1993-04-28 |
| IL104420A0 (en) | 1993-05-13 |
| FI930264A (fi) | 1993-07-24 |
| ZA93482B (en) | 1994-07-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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