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ES2195748B1 - RADAMYCIN, A PROCESS FOR ITS PRODUCTION AND ITS USE AS INDUCTOR OF THE TIPA PROMOTER. - Google Patents

RADAMYCIN, A PROCESS FOR ITS PRODUCTION AND ITS USE AS INDUCTOR OF THE TIPA PROMOTER.

Info

Publication number
ES2195748B1
ES2195748B1 ES200102609A ES200102609A ES2195748B1 ES 2195748 B1 ES2195748 B1 ES 2195748B1 ES 200102609 A ES200102609 A ES 200102609A ES 200102609 A ES200102609 A ES 200102609A ES 2195748 B1 ES2195748 B1 ES 2195748B1
Authority
ES
Spain
Prior art keywords
promoter
radamycin
production
inducer
tipa
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES200102609A
Other languages
Spanish (es)
Other versions
ES2195748A1 (en
Inventor
Ramon Santamaria Sanchez
Gloria Gonzalez Holgado
Jose Manuel Fernandez Abalos
Margarita Diaz Martinez
Julian Castro Rodriguez
Librada M. Cañedo Hernandez
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Consejo Superior de Investigaciones Cientificas CSIC
Universidad de Salamanca
Instituto Biomar SA
Original Assignee
Consejo Superior de Investigaciones Cientificas CSIC
Universidad de Salamanca
Instituto Biomar SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Consejo Superior de Investigaciones Cientificas CSIC, Universidad de Salamanca, Instituto Biomar SA filed Critical Consejo Superior de Investigaciones Cientificas CSIC
Priority to ES200102609A priority Critical patent/ES2195748B1/en
Priority to PCT/ES2002/000552 priority patent/WO2003044046A1/en
Priority to AU2002352278A priority patent/AU2002352278A1/en
Publication of ES2195748A1 publication Critical patent/ES2195748A1/en
Application granted granted Critical
Publication of ES2195748B1 publication Critical patent/ES2195748B1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/185—Heterocyclic compounds containing sulfur atoms as ring hetero atoms in the condensed system
    • C12R1/465—
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Radamicina, un proceso para su producción y su uso como inductor del promotor tipA. Esta invención describe un nuevo compuesto tiopeptídico cuya estructura ha sido determinada denominado radamicina (1). Asimismo, se describe el proceso de su producción y su uso, así como el de sus sales y derivados en todas sus formas estereométricas y tautoméricas, como inductor del promotor tipA. El compuesto aquí descrito se obtiene a partir de cultivo de Streptomyces sp RSP9 y difiere del resto de los compuestos tiopeptídicos en que es un potente inductor del promotor tipA. Además, el compuesto radamicina difiere de todos los inductores del promotor descritos hasta la fecha en que no presenta actividad antibiótica frente a ninguno de los microorganismos Gram positivos sensibles al resto de los compuestos tiopeptídicos probados hasta la fecha (Micrococcus luteus, Staphylococcus aureus, Bacillus subtilis etc).Radamycin, a process for its production and its use as an inducer of the tipA promoter. This invention describes a new thiopeptide compound whose structure has been determined called radamycin (1). Likewise, it describes the process of its production and its use, as well as that of its salts and derivatives in all its stereometric and tautomeric forms, as an inducer of the tipA promoter. The compound described here is obtained from the culture of Streptomyces sp RSP9 and differs from the rest of the thiopeptide compounds in that it is a potent inducer of the tipA promoter. In addition, the radamicin compound differs from all promoter inducers described to date in that it has no antibiotic activity against any of the Gram positive microorganisms sensitive to the rest of the thiopeptide compounds tested to date (Micrococcus luteus, Staphylococcus aureus, Bacillus subtilis etc).

ES200102609A 2001-11-23 2001-11-23 RADAMYCIN, A PROCESS FOR ITS PRODUCTION AND ITS USE AS INDUCTOR OF THE TIPA PROMOTER. Expired - Fee Related ES2195748B1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
ES200102609A ES2195748B1 (en) 2001-11-23 2001-11-23 RADAMYCIN, A PROCESS FOR ITS PRODUCTION AND ITS USE AS INDUCTOR OF THE TIPA PROMOTER.
PCT/ES2002/000552 WO2003044046A1 (en) 2001-11-23 2002-11-22 Radamicine, a production method thereof and the use of same as an inducer of the tipa promotor
AU2002352278A AU2002352278A1 (en) 2001-11-23 2002-11-22 Radamicine, a production method thereof and the use of same as an inducer of the tipa promotor

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES200102609A ES2195748B1 (en) 2001-11-23 2001-11-23 RADAMYCIN, A PROCESS FOR ITS PRODUCTION AND ITS USE AS INDUCTOR OF THE TIPA PROMOTER.

Publications (2)

Publication Number Publication Date
ES2195748A1 ES2195748A1 (en) 2003-12-01
ES2195748B1 true ES2195748B1 (en) 2005-03-01

Family

ID=8499555

Family Applications (1)

Application Number Title Priority Date Filing Date
ES200102609A Expired - Fee Related ES2195748B1 (en) 2001-11-23 2001-11-23 RADAMYCIN, A PROCESS FOR ITS PRODUCTION AND ITS USE AS INDUCTOR OF THE TIPA PROMOTER.

Country Status (3)

Country Link
AU (1) AU2002352278A1 (en)
ES (1) ES2195748B1 (en)
WO (1) WO2003044046A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102453077B (en) * 2010-10-26 2013-12-25 中国科学院上海有机化学研究所 Fluoronosiheptide and preparation method and application thereof
WO2024044748A2 (en) * 2022-08-26 2024-02-29 Wake Forest University Health Sciences Peroxiredoxin 3 inhibitors and methods of use for treating cancer

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0818539A1 (en) * 1996-07-11 1998-01-14 Hoechst Aktiengesellschaft Methylsulfomycin I, a process for its production and its use

Also Published As

Publication number Publication date
AU2002352278A1 (en) 2003-06-10
WO2003044046A1 (en) 2003-05-30
ES2195748A1 (en) 2003-12-01

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ES2195748B1 (en) RADAMYCIN, A PROCESS FOR ITS PRODUCTION AND ITS USE AS INDUCTOR OF THE TIPA PROMOTER.

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