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ES2191811T3 - Procedimiento para preparar derivados de 4-(2-(2-piridil)etoxi)benzaldehido. - Google Patents

Procedimiento para preparar derivados de 4-(2-(2-piridil)etoxi)benzaldehido.

Info

Publication number
ES2191811T3
ES2191811T3 ES97304554T ES97304554T ES2191811T3 ES 2191811 T3 ES2191811 T3 ES 2191811T3 ES 97304554 T ES97304554 T ES 97304554T ES 97304554 T ES97304554 T ES 97304554T ES 2191811 T3 ES2191811 T3 ES 2191811T3
Authority
ES
Spain
Prior art keywords
sup
formula
group
benzaldehido
piridil
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97304554T
Other languages
English (en)
Inventor
Yuzuru Saito
Hideya Mizufune
Makoto Yamashita
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Application granted granted Critical
Publication of ES2191811T3 publication Critical patent/ES2191811T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

UN METODO PARA LA PRODUCCION DE UN COMPUESTO REPRESENTADO POR LA FORMULA: EN LA QUE R{SUP,1} ES HIDROGENO O UN GRUPO ALQUILO O ACILO OPCIONALMENTE SUSTITUIDO, EL CUAL COMPRENDE LA REACCION DE UN COMPUESTO REPRESENTADO POR LA FORMULA: EN LA QUE R{SUP,1} TIENE EL MISMO SIGNIFICADO QUE EL DEFINIDO ANTERIORMENTE Y R{SUP,2} ES UN GRUPO ALQUILO OPCIONALMENTE HALOGENADO O UN GRUPO FENILO OPCIONALMENTE SUSTITUIDO CON UN COMPUESTO REPRESENTADO POR LA FORMULA: EN UN ALCOHOL INFERIOR EN PRESENCIA DE UN CARBONATO DE METAL ALCALINO O DE METAL ALCALINOTERREO; SIENDO EL COMPUESTO (III) UTIL COMO COMPUESTOS DE PARTIDA PARA LA PRODUCCION DE DERIVADOS TIAZOLIDINDIONA QUE TIENEN ACTIVIDADES HIPOGLUCEMICAS E HIPOLIPIDEMICAS.
ES97304554T 1996-06-27 1997-06-26 Procedimiento para preparar derivados de 4-(2-(2-piridil)etoxi)benzaldehido. Expired - Lifetime ES2191811T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP16786296 1996-06-27

Publications (1)

Publication Number Publication Date
ES2191811T3 true ES2191811T3 (es) 2003-09-16

Family

ID=15857471

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97304554T Expired - Lifetime ES2191811T3 (es) 1996-06-27 1997-06-26 Procedimiento para preparar derivados de 4-(2-(2-piridil)etoxi)benzaldehido.

Country Status (9)

Country Link
US (2) US5952509A (es)
EP (1) EP0816340B1 (es)
AT (1) ATE238282T1 (es)
CA (1) CA2208878C (es)
CY (1) CY2393B1 (es)
DE (1) DE69721134T2 (es)
DK (1) DK0816340T3 (es)
ES (1) ES2191811T3 (es)
PT (1) PT816340E (es)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030153607A1 (en) * 1998-11-12 2003-08-14 Smithkline Beecham P.L.C. Novel composition and use
AR023699A1 (es) * 1998-11-12 2002-09-04 Smithkline Beecham Corp Una composicion farmaceutica que comprende un estabilizador de insulina y un procedimiento para preparar una composicion farmaceutica
US20040102486A1 (en) * 1998-11-12 2004-05-27 Smithkline Beecham Corporation Novel method of treatment
WO2002028857A1 (en) * 2000-10-05 2002-04-11 Dr. Reddy's Research Foundation Polymorphs of pioglitazone hydrochloride and their use as antidiabetics
FR2820742B1 (fr) * 2001-02-14 2005-03-11 Ppg Sipsy Procede de preparation de composes derives de thiazolidinedione, d'oxazolidinedione ou d'hydantoine
AU2002311057A1 (en) 2001-04-26 2002-11-11 Leciva, A.S. Method for obtaining pioglitazone as an antidiabetic agent
WO2003026586A2 (en) 2001-09-28 2003-04-03 Teva Pharmaceutical Industries Ltd. Pioglitazone hydrochloride
WO2003053367A2 (en) * 2001-12-20 2003-07-03 Teva Pharmaceutical Industries Ltd. Hydrogenation of precursors to thiazolidinedione antihyperglycemics
US20050187258A1 (en) * 2001-12-20 2005-08-25 Ben-Zion Dolitzky Hydrogenation of precursors to thiazolidinedione antihyperglycemics
AU2003228767A1 (en) * 2002-04-29 2003-11-17 Teva Pharmaceutical Industries Ltd. Processes for preparing losartan and losartan potassium
WO2004000810A1 (en) * 2002-06-19 2003-12-31 Eos Eczacibasi Ozgun Kimyasal Urunler Sanyi Ve Ticaret A.S. A process for the production of substituted phenyl ethers
US7232828B2 (en) * 2002-08-10 2007-06-19 Bethesda Pharmaceuticals, Inc. PPAR Ligands that do not cause fluid retention, edema or congestive heart failure
AU2003260813A1 (en) * 2002-09-12 2004-04-30 Themis Laboratories Private Limited Improved process for preparation of thiazolidinedione derivatives
AR045330A1 (es) * 2003-08-07 2005-10-26 Sb Pharmco Inc Forma de dosificacion oral, procedimiento para su preparacion y uso del compuesto 5-(4-(2-(n-metil-n- (2-piridil)amino)etoxi )bencil) tiazolidin-2,4-diona o una sal o solvato farmaceuticamente aceptable del mismo para prepararla
GB0318824D0 (en) * 2003-08-11 2003-09-10 Glaxo Group Ltd Novel composition
US20070078170A1 (en) * 2003-08-28 2007-04-05 Khanduri Chandra H Process for the preparation of pioglitazone
GB0325174D0 (en) 2003-10-28 2003-12-03 Sandoz Ag Organic compounds
HUP0304096A2 (hu) * 2003-12-19 2005-08-29 Richter Gedeon Vegyészeti Gyár Rt. Eljárás pioglitazon hidrogénklorid előállítására és intermedierjei
EP1745043A1 (en) * 2004-05-12 2007-01-24 Medichem S.A. Process for the preparation of rosiglitazone
EA013161B1 (ru) * 2005-06-08 2010-02-26 Орион Корпорейшн Дозированная форма для перорального применения
US20080182880A1 (en) * 2006-09-28 2008-07-31 Mailatur Sivaraman Mohan Pioglitazone composition
TW200914006A (en) * 2007-07-12 2009-04-01 Takeda Pharmaceutical Coated preparation
WO2012153312A1 (en) 2011-05-11 2012-11-15 Ranbaxy Laboratories Limited Process for the purification of pioglitazone
EP3388064B1 (en) 2014-04-02 2021-03-10 Minoryx Therapeutics S.L. 2,4-thiazolidinedione derivatives in the treatment of central nervous system disorders
EA201991304A1 (ru) 2016-12-01 2019-12-30 Минорикс Терапьютикс С.Л. 5-[[4-[2-[5-(1-гидроксиэтил)пиридин-2-ил]этокси]фенил]метил]-1,3-тиазолидин-2,4-дион для лечения неалкогольной жировой болезни печени
US11124505B2 (en) 2016-12-23 2021-09-21 Minoryx Therapeutics S.L. Process for preparing 5-[[4-[2-[5-(1-hydroxyethyl)-2-pyridinyl]ethoxy]phenyl]methyl]-2,4-thiazolidinedione and salts thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR240698A1 (es) * 1985-01-19 1990-09-28 Takeda Chemical Industries Ltd Procedimiento para preparar compuestos de 5-(4-(2-(5-etil-2-piridil)-etoxi)benzil)-2,4-tiazolidindiona y sus sales
US4812570A (en) * 1986-07-24 1989-03-14 Takeda Chemical Industries, Ltd. Method for producing thiazolidinedione derivatives
EP0506273B1 (en) * 1991-03-25 1995-05-31 Takeda Chemical Industries, Ltd. Method for producing ethers
KR100249988B1 (ko) * 1991-04-11 2000-04-01 로렌스 티. 마이젠헬더 티아졸리딘디온 유도체, 그의 제조방법 및 용도

Also Published As

Publication number Publication date
DE69721134D1 (de) 2003-05-28
US5952509A (en) 1999-09-14
DK0816340T3 (da) 2003-07-14
EP0816340B1 (en) 2003-04-23
CY2393B1 (en) 2004-09-10
EP0816340A1 (en) 1998-01-07
DE69721134T2 (de) 2004-03-04
ATE238282T1 (de) 2003-05-15
US6100403A (en) 2000-08-08
PT816340E (pt) 2003-08-29
CA2208878A1 (en) 1997-12-27
CA2208878C (en) 2002-08-20

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