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ES2184989T3 - Derivados de feniletanolaminotetralincarboxamida 3,4-disustituidos. - Google Patents

Derivados de feniletanolaminotetralincarboxamida 3,4-disustituidos.

Info

Publication number
ES2184989T3
ES2184989T3 ES97902714T ES97902714T ES2184989T3 ES 2184989 T3 ES2184989 T3 ES 2184989T3 ES 97902714 T ES97902714 T ES 97902714T ES 97902714 T ES97902714 T ES 97902714T ES 2184989 T3 ES2184989 T3 ES 2184989T3
Authority
ES
Spain
Prior art keywords
carbon atom
amino
phenylethanolaminotetralincarboxamida
derivatives
indicates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97902714T
Other languages
English (en)
Inventor
Makio Kitazawa
Kosuke Okazaki
Tetsuro Tamai
Masaru Saito
Nobuyuki Tanaka
Hiroaki Kobayashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kissei Pharmaceutical Co Ltd
Original Assignee
Kissei Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=13386565&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2184989(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Kissei Pharmaceutical Co Ltd filed Critical Kissei Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2184989T3 publication Critical patent/ES2184989T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/04—Drugs for disorders of the urinary system for urolithiasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/06—Antiabortive agents; Labour repressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C235/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Endocrinology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
  • Detergent Compositions (AREA)

Abstract

DERIVADOS FENILETANOLAMINOTETRALINCARBOXAMIDA 3,4 DISUSTITUIDOS REPRESENTADOS POR LA FORMULA GENERAL (1) Y SUS SALES FARMACOLOGICAMENTE ACEPTABLES QUE TIENEN UN EFECTO ESTIMULANTE SELECTIVO DEL RECEPTOR BE 2 - ADRENERGICO CON UN EFECTO MITIGADO SOBRE EL CORAZON, COMO UN PULSO FRECUENTE. EN DICHA FORMULA, A REPRESENTA ALQUILENO INFERIOR; B REPRESENTA AMINO, DI(ALQUIL INFERIOR)AMINO O UN AMINO ALICICLICO DE 3 A 7 ESLABONES QUE CONTIENEN OPCIONALMENTE OXIGENO EN EL ANILLO; N ES UN NUMERO ENTERO, 1 O 2; EL ATOMO DE CARBONO MARCADO CON "*" INDICA UN ATOMO DE CARBONO O LA CONFIGURACION R O S O UNA MEZCLA DE LOS MISMOS Y EL ATOMO DE CARBONO MARCADO CON "(S)" INDICA UN ATOMO DE CARBONO DE LA CONFIGURACION S. ESTOS COMPUESTOS SON UTILES PARA PREVENIR LA AMENAZA DE ABORTO/PARTO PREMATURO, COMO AGENTE BRONCODILATADOR, ANALGESICO Y LITAGOGO EN LA URETEROLITIASIS.
ES97902714T 1996-02-19 1997-02-18 Derivados de feniletanolaminotetralincarboxamida 3,4-disustituidos. Expired - Lifetime ES2184989T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP6888596 1996-02-19

Publications (1)

Publication Number Publication Date
ES2184989T3 true ES2184989T3 (es) 2003-04-16

Family

ID=13386565

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97902714T Expired - Lifetime ES2184989T3 (es) 1996-02-19 1997-02-18 Derivados de feniletanolaminotetralincarboxamida 3,4-disustituidos.

Country Status (24)

Country Link
US (1) US6133266A (es)
EP (1) EP0882704B1 (es)
JP (1) JP3892045B2 (es)
KR (1) KR100491633B1 (es)
CN (1) CN1100032C (es)
AT (1) ATE225767T1 (es)
AU (1) AU725042B2 (es)
BR (1) BR9707566B1 (es)
CA (1) CA2245490C (es)
CZ (1) CZ293974B6 (es)
DE (1) DE69716242T2 (es)
DK (1) DK0882704T3 (es)
EA (1) EA002143B1 (es)
ES (1) ES2184989T3 (es)
HU (1) HU229400B1 (es)
ID (1) ID16091A (es)
MY (1) MY123853A (es)
NO (1) NO323095B1 (es)
NZ (1) NZ331445A (es)
PL (1) PL186411B1 (es)
PT (1) PT882704E (es)
SG (1) SG72727A1 (es)
TW (1) TW375604B (es)
WO (1) WO1997030023A1 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU8562098A (en) * 1997-08-19 1999-03-08 Kissei Pharmaceutical Co. Ltd. Phenylethanolaminotetralin derivatives and bronchodilators
ZA994264B (en) 1998-07-01 2000-01-25 Warner Lambert Co Stereoisomers with high affinity for adrenergic receptors.
GB9913083D0 (en) 1999-06-04 1999-08-04 Novartis Ag Organic compounds
US7232837B2 (en) 1999-06-29 2007-06-19 Mcneil-Ppc, Inc. Stereoisomers with high affinity for adrenergic receptors
FR2809725B1 (fr) * 2000-06-06 2004-05-07 Sanofi Synthelabo Propanolaminotetralines, leur preparation et compositions pharmaceutiques en contenant
GB0029562D0 (en) 2000-12-04 2001-01-17 Novartis Ag Organic compounds
EP1591115A4 (en) * 2003-01-22 2009-09-16 Kissei Pharmaceutical PREVENTIVE AGENT OR REMEDY AGAINST THE EMRYONARY DEVELOPMENT INTRA-UTERIN LATE OR PUERPERAL FEVER
JPWO2006054513A1 (ja) * 2004-11-19 2008-05-29 キッセイ薬品工業株式会社 神経因性疼痛の予防又は治療剤
WO2006054514A1 (ja) * 2004-11-19 2006-05-26 Kissei Pharmaceutical Co., Ltd. 神経因性疼痛の予防又は治療用医薬組成物
EP2098511A1 (en) 2008-03-07 2009-09-09 Solvias AG Process for preparing compounds containing a hydronaphtalene structure with an unsymmetrically substituted benzene ring
JP2013511528A (ja) * 2009-11-18 2013-04-04 メディシノバ，インコーポレーテッド 喘息の急性憎悪の治療及びそれに罹患した患者の入院の可能性の低減
JP2013522206A (ja) * 2010-03-08 2013-06-13 メディシノヴァ， インコーポレイテッド． 月経困難症の治療用組成物、その処置方法及びその治療用装置
BR112012025703A2 (pt) 2010-04-08 2016-07-05 Medicinova Inc métodos e composições para o tratamento de síndrome de intestino irritável

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9107827D0 (en) * 1991-04-12 1991-05-29 Fujisawa Pharmaceutical Co New ethanolamine derivatives,processes for the preparation thereof and pharmaceutical composition comprising the same
IL104567A (en) * 1992-02-03 1997-03-18 Fujisawa Pharmaceutical Co Ethanolamine derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same
WO1993018007A1 (en) * 1992-03-13 1993-09-16 Tokyo Tanabe Company Limited Novel carbostyril derivative

Also Published As

Publication number Publication date
NO323095B1 (no) 2007-01-02
CA2245490C (en) 2005-10-25
CZ293974B6 (cs) 2004-09-15
EP0882704A1 (en) 1998-12-09
EA002143B1 (ru) 2001-12-24
KR100491633B1 (ko) 2005-09-09
BR9707566B1 (pt) 2010-08-10
NO983777L (no) 1998-10-19
NO983777D0 (no) 1998-08-18
EA199800644A1 (ru) 1999-02-25
DK0882704T3 (da) 2003-02-17
US6133266A (en) 2000-10-17
HUP9900621A2 (hu) 1999-08-30
KR19990082638A (ko) 1999-11-25
ID16091A (id) 1997-09-04
PT882704E (pt) 2003-02-28
TW375604B (en) 1999-12-01
EP0882704A4 (en) 2000-06-14
MY123853A (en) 2006-06-30
CN1100032C (zh) 2003-01-29
DE69716242D1 (de) 2002-11-14
PL186411B1 (pl) 2004-01-30
AU725042B2 (en) 2000-10-05
NZ331445A (en) 2000-01-28
ATE225767T1 (de) 2002-10-15
HUP9900621A3 (en) 1999-11-29
CA2245490A1 (en) 1997-08-21
HU229400B1 (en) 2013-12-30
PL328530A1 (en) 1999-02-01
JP3892045B2 (ja) 2007-03-14
BR9707566A (pt) 1999-07-27
DE69716242T2 (de) 2003-07-24
EP0882704B1 (en) 2002-10-09
CZ252398A3 (cs) 1998-12-16
WO1997030023A1 (fr) 1997-08-21
CN1216526A (zh) 1999-05-12
SG72727A1 (en) 2000-05-23
AU2001497A (en) 1997-09-02

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