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ES2178725T3 - PROCEDURE TO PREPARE 2,4-DIHYDROXIPIRIDINE AND 2,4-DIHIDROXI-3-NITROPIRIDINE. - Google Patents

PROCEDURE TO PREPARE 2,4-DIHYDROXIPIRIDINE AND 2,4-DIHIDROXI-3-NITROPIRIDINE.

Info

Publication number
ES2178725T3
ES2178725T3 ES96945096T ES96945096T ES2178725T3 ES 2178725 T3 ES2178725 T3 ES 2178725T3 ES 96945096 T ES96945096 T ES 96945096T ES 96945096 T ES96945096 T ES 96945096T ES 2178725 T3 ES2178725 T3 ES 2178725T3
Authority
ES
Spain
Prior art keywords
dihydroxipiridine
prepare
nitropiridine
dihidroxi
day
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96945096T
Other languages
Spanish (es)
Inventor
Larry K Truesdale
James P Sherbine
Benoit J Vanasse
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Aventis Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharmaceuticals Inc filed Critical Aventis Pharmaceuticals Inc
Application granted granted Critical
Publication of ES2178725T3 publication Critical patent/ES2178725T3/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

LA PRESENTE INVENCION SE DIRIGE A UN PROCESO PARA PREPARAR 2,4 DIHIDROXIPIRIDINA, QUE COMPRENDE CALENTAR UN COMPUESTO DE FORMULA A, EN LA QUE R ES H, ALKILO O ARALKILO Y ACIDO FOSFORICO, EN EL QUE LA RELACION ENTRE ACIDO FOSFORICO Y AGUA ES NO INFERIOR A UN 27 - 1% EN PESO. LA INVENCION SE DIRIGE IGUALMENTE A UN PROCESO PARA PREPARAR 2,4 - DIHIDROXI - 3 - NITROPIRIDINA, QUE COMPRENDE HACER REACCIONAR 2,4 - DIHIDROXIPIRIDINA CON ACIDO NITRICO. EL PROCESO DE LA PRESENTE INVENCION PREPARA INTERMEDIOS QUE SON UTILES PARA LA PREPARACION DE COMPUESTOS APROPIADOS PARA EL TRATAMIENTO DE ENFERMEDADES CARDIOVASCULARES MARCADAS POR HIPERTENSION O ISQUEMIA MIOCARDICA, MEJORAR LAS LESIONES ISQUEMICAS O EL TAMAÑO DEL INFARTO DE MIOCARDIO, O TRATAR LA HIPERLIPIDEMIA O LA HIPERCOLESTEROLEMIA.THE PRESENT INVENTION IS DIRECTED TO A PROCESS TO PREPARE 2,4 DIHYDROXIPIRIDINE, WHICH INCLUDES HEATING A FORMULA COMPOUND A, IN WHICH R IS H, ALKILO OR ARALKILO AND PHOSPHORIC ACID, IN WHICH THE RELATIONSHIP BETWEEN PHOSPHORIC ACID AND WATER IS LESS THAN 27 - 1% BY WEIGHT. THE INVENTION IS ALWAYS DIRECTED TO A PROCESS TO PREPARE 2,4-DIHIDROXI-3-NITROPIRIDINE, WHICH INCLUDES TO REACT 2,4-DIHYDROXIPIRIDINE WITH NITRIC ACID. THE PROCESS OF THE PRESENT INVENTION PREPARES INTERMEDIATES THAT ARE USEFUL FOR THE PREPARATION OF SUITABLE COMPOUNDS FOR THE TREATMENT OF CARDIOVASCULAR DISEASES MARKED BY HYPERTENSION OR MIOCARDIC ISCHEMIA, IMPROVE ISCHEMICAL INJURIES OR THE THREE-DAY THREE-DAY THREE-DAY ORDER.

ES96945096T 1996-01-02 1996-12-23 PROCEDURE TO PREPARE 2,4-DIHYDROXIPIRIDINE AND 2,4-DIHIDROXI-3-NITROPIRIDINE. Expired - Lifetime ES2178725T3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US949296P 1996-01-02 1996-01-02

Publications (1)

Publication Number Publication Date
ES2178725T3 true ES2178725T3 (en) 2003-01-01

Family

ID=21737998

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96945096T Expired - Lifetime ES2178725T3 (en) 1996-01-02 1996-12-23 PROCEDURE TO PREPARE 2,4-DIHYDROXIPIRIDINE AND 2,4-DIHIDROXI-3-NITROPIRIDINE.

Country Status (22)

Country Link
US (2) US6307054B1 (en)
EP (1) EP0909270B1 (en)
JP (1) JP2000502709A (en)
KR (1) KR19990076966A (en)
AP (1) AP772A (en)
AT (1) ATE219767T1 (en)
AU (1) AU722894B2 (en)
BR (1) BR9612341A (en)
CA (1) CA2241887C (en)
CZ (1) CZ203998A3 (en)
DE (1) DE69622051T2 (en)
DK (1) DK0909270T3 (en)
EA (1) EA000884B1 (en)
ES (1) ES2178725T3 (en)
HK (1) HK1019590A1 (en)
HU (1) HUP9900969A3 (en)
IL (1) IL125164A (en)
OA (1) OA10803A (en)
PT (1) PT909270E (en)
SI (1) SI9620137B (en)
SK (1) SK283625B6 (en)
WO (1) WO1997024327A1 (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9917000A (en) 1998-12-31 2001-12-11 Aventis Pharm Prod Inc Process for preparing n6-substituted deesaza-adenosine derivatives
US7018365B2 (en) 1999-05-21 2006-03-28 Micro Therapeutics, Inc. Threaded syringe with quick stop
US6784165B1 (en) * 1999-11-23 2004-08-31 Aderis Pharmaceuticals, Inc. Treatment of heart rhythm disturbances with N6-substituted-5′-(N-substituted) carboxamidoadenosines
US7291603B2 (en) 2002-07-24 2007-11-06 Ptc Therapeutics, Inc. Nucleoside compounds and their use for treating cancer and diseases associated with somatic mutations
US20050009776A1 (en) * 2003-04-24 2005-01-13 Aderis Pharmaceuticals, Inc. Method of treating atrial fibrillation or atrial flutter
WO2005025545A2 (en) * 2003-09-17 2005-03-24 Aderis Pharmaceuticals, Inc. Pharmaceutical formulation for controlled release of selodenoson
GT200500281A (en) * 2004-10-22 2006-04-24 Novartis Ag ORGANIC COMPOUNDS.
GB0500785D0 (en) * 2005-01-14 2005-02-23 Novartis Ag Organic compounds
GB0607948D0 (en) * 2006-04-21 2006-05-31 Novartis Ag Organic compounds
PT2322525E (en) 2006-04-21 2013-12-26 Novartis Ag Purine derivatives for use as adenosin a2a receptor agonists
GB0607944D0 (en) * 2006-04-21 2006-05-31 Novartis Ag Organic compounds
GB0607953D0 (en) * 2006-04-21 2006-05-31 Novartis Ag Organic compounds
GB0607950D0 (en) * 2006-04-21 2006-05-31 Novartis Ag Organic compounds
EP1889846A1 (en) 2006-07-13 2008-02-20 Novartis AG Purine derivatives as A2a agonists
EP1903044A1 (en) * 2006-09-14 2008-03-26 Novartis AG Adenosine Derivatives as A2A Receptor Agonists
JP2010508835A (en) * 2006-11-10 2010-03-25 ノバルティス アーゲー Cyclopentenediol monoacetate derivative
JP2012516843A (en) 2009-02-02 2012-07-26 インドコ レメディーズ リミテッド Method for preparing nitropyridine derivatives
CN114349873B (en) * 2021-04-12 2023-03-17 杭州安誉科技有限公司 High-strength fan bracket for porous module auxiliary control device

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3547935A (en) * 1967-08-07 1970-12-15 American Cyanamid Co Certain nitro-4-pyridinols,n-oxides thereof and derivatives thereof
GB1199699A (en) * 1968-01-08 1970-07-22 Glanzstoff Ag Process for the Production of Condensed Aromatic Bis-(2,4-Dihydroxypyridine) Derivatives
DE3308449A1 (en) * 1982-08-19 1984-03-15 Rütgerswerke AG, 6000 Frankfurt METHOD FOR REPRESENTING 2-CHLORINE-6-ALKOXY-3-NITROPYRIDINE
JP3261190B2 (en) * 1993-01-27 2002-02-25 広栄化学工業株式会社 Method for producing 2-hydroxy-3,5-dinitropyridines

Also Published As

Publication number Publication date
EA000884B1 (en) 2000-06-26
EP0909270A4 (en) 1999-04-21
SI9620137B (en) 2006-02-28
JP2000502709A (en) 2000-03-07
US6392049B1 (en) 2002-05-21
IL125164A0 (en) 1999-01-26
IL125164A (en) 2003-03-12
DE69622051T2 (en) 2003-01-23
BR9612341A (en) 1999-12-28
ATE219767T1 (en) 2002-07-15
AP772A (en) 1999-10-15
EA199800621A1 (en) 1999-02-25
EP0909270A1 (en) 1999-04-21
US6307054B1 (en) 2001-10-23
HUP9900969A3 (en) 2001-11-28
KR19990076966A (en) 1999-10-25
CA2241887A1 (en) 1997-07-10
OA10803A (en) 2003-01-28
DK0909270T3 (en) 2002-10-07
AU722894B2 (en) 2000-08-10
DE69622051D1 (en) 2002-08-01
SK283625B6 (en) 2003-10-07
SK90698A3 (en) 2000-12-11
AU1354697A (en) 1997-07-28
PT909270E (en) 2002-11-29
HUP9900969A2 (en) 1999-07-28
AP9801289A0 (en) 1998-09-30
CZ203998A3 (en) 1999-11-17
CA2241887C (en) 2004-02-24
SI9620137A (en) 1999-02-28
HK1019590A1 (en) 2000-02-18
WO1997024327A1 (en) 1997-07-10
EP0909270B1 (en) 2002-06-26

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