ES2172173T3 - 2-aminopiridinas con sustituyentes alcoxi ramificados como inhibidores de la nos. - Google Patents
2-aminopiridinas con sustituyentes alcoxi ramificados como inhibidores de la nos.Info
- Publication number
- ES2172173T3 ES2172173T3 ES98935247T ES98935247T ES2172173T3 ES 2172173 T3 ES2172173 T3 ES 2172173T3 ES 98935247 T ES98935247 T ES 98935247T ES 98935247 T ES98935247 T ES 98935247T ES 2172173 T3 ES2172173 T3 ES 2172173T3
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- substituents
- amino
- independently selected
- nitrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/73—Unsubstituted amino or imino radicals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Ophthalmology & Optometry (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Addiction (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Dermatology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
Un compuesto de fórmula 6 en el que X es CHOH, CH2 o CHR10, en la que R10, junto con X, el grupo CH2 adyacente a X y el nitrógeno de NR1R2, forman un anillo saturado de cinco o seis eslabones; R1, R2, R3 y R4 se seleccionan independientemente entre alquilo C1- C6, tetrahidronaftaleno, arilo y aralquilo, siendo dicho arilo y el radical arilo de dicho aralquilo fenilo o naftilo y el radical alquilo es lineal o ramificado y contiene de 1 a 6 átomos de carbono, y pudiendo dicho alquilo C1-C6, dicho tetrahidronaftaleno y el radical arilo de dicho aralquilo estar sustituidos opcionalmente por uno a tres sustituyentes, preferiblemente de cero a dos sustituyentes, seleccionados independientemente entre halo (por ejemplo, cloro, fluoro, bromo, yodo), nitro, hidroxi, ciano, amino, alcoxi C1-C4 y (alquil C1-C4)-amino; o R1 y R2 junto con el nitrógeno al que están unidos, forman un anillo de piperazina, piperidina o pirrolidina o un anillo azabicíclico que contiene de 6 a 14 elementos, 1 a 3 de los cuales son nitrógeno y el resto de los cuales son carbono; y en el que dichos anillos de piperazina, piperidina y pirrolidina pueden estar sustituidos opcionalmente por uno o más sustituyentes, preferiblemente por cero a dos sustituyentes, seleccionados independientemente entre alquilo C1-C6, amino, (alquil C1-C6)amino, di(alquil C1- C6)amino, anillos heterocíclicos de 5 a 6 eslabones fenilsustituidos que contienen de 1 a 4 átomos de nitrógeno en los anillos, benzoílo, benzoilmetilo, bencilcarbonilo, fenilaminocarbonilo, feniletilo y fenoxicarbonilo, y pudiendo los radicales fenilo de cualquiera de los sustituyentes antes mencionados estar sustituidos opcionalmente por uno o más sustituyentes, preferiblemente por cero a dos sustituyentes, seleccionados independientemente entre halo, alquilo C1-C3, alcoxi C1-C3, nitro, amino, ciano, CF3 y OCF3; y las sales farmacéuticamente aceptables de dicho compuesto.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5773997P | 1997-08-28 | 1997-08-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2172173T3 true ES2172173T3 (es) | 2002-09-16 |
Family
ID=22012464
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES98935247T Expired - Lifetime ES2172173T3 (es) | 1997-08-28 | 1998-08-11 | 2-aminopiridinas con sustituyentes alcoxi ramificados como inhibidores de la nos. |
Country Status (32)
| Country | Link |
|---|---|
| US (2) | US6362195B1 (es) |
| EP (1) | EP1007512B1 (es) |
| JP (1) | JP3441714B2 (es) |
| CN (1) | CN1268122A (es) |
| AP (1) | AP9801331A0 (es) |
| AR (1) | AR016644A1 (es) |
| AT (1) | ATE215532T1 (es) |
| AU (1) | AU8458698A (es) |
| BR (1) | BR9811921A (es) |
| CA (1) | CA2302436C (es) |
| DE (1) | DE69804635T2 (es) |
| DK (1) | DK1007512T3 (es) |
| EA (1) | EA200000165A1 (es) |
| ES (1) | ES2172173T3 (es) |
| GT (1) | GT199800135A (es) |
| HN (1) | HN1998000125A (es) |
| HR (1) | HRP980476A2 (es) |
| HU (1) | HUP0002803A2 (es) |
| ID (1) | ID24318A (es) |
| IL (1) | IL134302A0 (es) |
| IS (1) | IS5342A (es) |
| MA (1) | MA26538A1 (es) |
| NO (1) | NO20000957L (es) |
| OA (1) | OA11294A (es) |
| PA (1) | PA8458301A1 (es) |
| PE (1) | PE106699A1 (es) |
| PL (1) | PL339008A1 (es) |
| PT (1) | PT1007512E (es) |
| SI (1) | SI1007512T1 (es) |
| TN (1) | TNSN98157A1 (es) |
| WO (1) | WO1999011620A1 (es) |
| ZA (1) | ZA987788B (es) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20010049379A1 (en) | 1997-08-27 | 2001-12-06 | Lowe John Adams | 2-aminopyridines containing fused ring substituents |
| KR20010085364A (ko) * | 1998-08-11 | 2001-09-07 | 데이비드 존 우드 | Ｎｏｓ 억제제에 대한 신규 제약 용도 |
| OA11841A (en) | 1999-02-25 | 2005-08-22 | Pfizer Prod Inc | 2-Aminopyridines containing fused ring substituents. |
| EP1203095A2 (en) * | 1999-07-30 | 2002-05-08 | University College London | Screen for nitric oxide synthase modulators |
| GB2371547A (en) * | 1999-07-30 | 2002-07-31 | Univ London | Inducible screen for drug discovery |
| GB0004151D0 (en) | 2000-02-23 | 2000-04-12 | Astrazeneca Uk Ltd | Novel use |
| GB0004149D0 (en) * | 2000-02-23 | 2000-04-12 | Astrazeneca Uk Ltd | Novel compounds |
| GB0004152D0 (en) * | 2000-02-23 | 2000-04-12 | Astrazeneca Uk Ltd | Novel compounds |
| GB0004153D0 (en) * | 2000-02-23 | 2000-04-12 | Astrazeneca Uk Ltd | Novel use |
| US6469172B2 (en) * | 2000-03-08 | 2002-10-22 | Merck & Co., Inc. | Process for the preparation of chemical compounds |
| SE0102640D0 (sv) | 2001-07-31 | 2001-07-31 | Astrazeneca Ab | Novel compounds |
| US20040077853A1 (en) * | 2001-10-10 | 2004-04-22 | Pfizer Inc. | 2-amino-6-(2,4,5-substituted-phenyl)-pyridines |
| EP1501511A4 (en) * | 2002-05-06 | 2006-06-07 | Univ Washington | METHODS OF TREATING GLAUCOMA AND OTHER CONDITIONS INDUCED BY EXPRESSION OF NOS-2 BY INHIBITING THE EGFR PATHWAY |
| WO2005007627A1 (ja) * | 2003-07-18 | 2005-01-27 | Nihon Nohyaku Co., Ltd. | フェニルピリジン誘導体、その中間体及びこれを有効成分とする除草剤 |
| WO2006053109A1 (en) * | 2004-11-10 | 2006-05-18 | Synta Pharmaceuticals Corp. | Heteroaryl compounds |
| CA2651732C (en) * | 2006-05-18 | 2014-10-14 | Mannkind Corporation | Intracellular kinase inhibitors |
| UA105182C2 (ru) | 2008-07-03 | 2014-04-25 | Ньюрексон, Інк. | Бензоксазины, бензотиазины и родственные соединения, которые имеют ингибирующую nos активность |
| EP3002279A1 (de) | 2014-10-02 | 2016-04-06 | Bayer CropScience AG | Verfahren zur Herstellung von 3-(5-Aminotriazolyl)-Sulfid-Derivaten |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5892112A (en) * | 1990-11-21 | 1999-04-06 | Glycomed Incorporated | Process for preparing synthetic matrix metalloprotease inhibitors |
| AU4515696A (en) | 1994-12-12 | 1996-07-03 | Merck & Co., Inc. | Substituted 2-aminopyridines as inhibitors of nitric oxide synthase |
| US5972975A (en) * | 1995-12-08 | 1999-10-26 | Merck & Co., Inc. | Substituted 2-aminopyridines as inhibitors of nitric oxide synthase |
| US6066642A (en) * | 1996-01-29 | 2000-05-23 | The United States Of America As Represented By The Department Of Health And Human Services | Dihydropyridine-, pyridine-, benzopyran-4-one- and triazoloquinazoline derivative, their preparation and their use as adenosine receptor antagonists |
| WO1997036871A1 (en) * | 1996-03-29 | 1997-10-09 | Pfizer Inc. | 6-phenylpyridyl-2-amine derivatives |
| HN1997000027A (es) | 1996-12-06 | 1997-06-05 | Pfizer Prod Inc | Derivados de 6-fenil piridil - 2 amina |
-
1998
- 1998-08-10 HN HN1998000125A patent/HN1998000125A/es unknown
- 1998-08-11 PT PT98935247T patent/PT1007512E/pt unknown
- 1998-08-11 JP JP2000508660A patent/JP3441714B2/ja not_active Expired - Fee Related
- 1998-08-11 EA EA200000165A patent/EA200000165A1/ru unknown
- 1998-08-11 CN CN98808459A patent/CN1268122A/zh active Pending
- 1998-08-11 EP EP98935247A patent/EP1007512B1/en not_active Expired - Lifetime
- 1998-08-11 SI SI9830136T patent/SI1007512T1/xx unknown
- 1998-08-11 AT AT98935247T patent/ATE215532T1/de not_active IP Right Cessation
- 1998-08-11 ID IDW20000359A patent/ID24318A/id unknown
- 1998-08-11 BR BR9811921-4A patent/BR9811921A/pt not_active Application Discontinuation
- 1998-08-11 CA CA002302436A patent/CA2302436C/en not_active Expired - Fee Related
- 1998-08-11 IL IL13430298A patent/IL134302A0/xx unknown
- 1998-08-11 ES ES98935247T patent/ES2172173T3/es not_active Expired - Lifetime
- 1998-08-11 US US09/381,887 patent/US6362195B1/en not_active Expired - Fee Related
- 1998-08-11 HU HU0002803A patent/HUP0002803A2/hu unknown
- 1998-08-11 AU AU84586/98A patent/AU8458698A/en not_active Abandoned
- 1998-08-11 DE DE69804635T patent/DE69804635T2/de not_active Expired - Fee Related
- 1998-08-11 DK DK98935247T patent/DK1007512T3/da active
- 1998-08-11 PL PL98339008A patent/PL339008A1/xx unknown
- 1998-08-11 WO PCT/IB1998/001223 patent/WO1999011620A1/en active IP Right Grant
- 1998-08-17 GT GT199800135A patent/GT199800135A/es unknown
- 1998-08-24 PE PE1998000770A patent/PE106699A1/es not_active Application Discontinuation
- 1998-08-26 TN TNTNSN98157A patent/TNSN98157A1/fr unknown
- 1998-08-26 PA PA19988458301A patent/PA8458301A1/es unknown
- 1998-08-26 AR ARP980104258A patent/AR016644A1/es unknown
- 1998-08-26 MA MA25230A patent/MA26538A1/fr unknown
- 1998-08-27 ZA ZA9807788A patent/ZA987788B/xx unknown
- 1998-08-27 AP APAP/P/1998/001331A patent/AP9801331A0/en unknown
- 1998-08-28 HR HR60/057,739A patent/HRP980476A2/hr not_active Application Discontinuation
-
2000
- 2000-01-14 IS IS5342A patent/IS5342A/is unknown
- 2000-02-25 OA OA1200000053A patent/OA11294A/en unknown
- 2000-02-25 NO NO20000957A patent/NO20000957L/no not_active Application Discontinuation
-
2001
- 2001-09-20 US US09/957,398 patent/US20020022642A1/en not_active Abandoned
Also Published As
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