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ES2170402T3 - Derivados de benzo(g)quinolina. - Google Patents

Derivados de benzo(g)quinolina.

Info

Publication number
ES2170402T3
ES2170402T3 ES97931793T ES97931793T ES2170402T3 ES 2170402 T3 ES2170402 T3 ES 2170402T3 ES 97931793 T ES97931793 T ES 97931793T ES 97931793 T ES97931793 T ES 97931793T ES 2170402 T3 ES2170402 T3 ES 2170402T3
Authority
ES
Spain
Prior art keywords
quinolina
benzo
derivatives
formula
myopia
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97931793T
Other languages
English (en)
Inventor
Peter Gull
Rudolf Markstein
Max Peter Seiler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9614282.3A external-priority patent/GB9614282D0/en
Priority claimed from GBGB9626093.0A external-priority patent/GB9626093D0/en
Application filed by Novartis AG filed Critical Novartis AG
Application granted granted Critical
Publication of ES2170402T3 publication Critical patent/ES2170402T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/10—Ophthalmic agents for accommodation disorders, e.g. myopia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Ophthalmology & Optometry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

EN LA INVENCION SE PRESENTA UN COMPUESTO DE FORMULA (I) EN LA QUE A, B, X, Y Y R REPRESENTAN LO DEFINIDO EN LA DESCRIPCION Y UN PROCEDIMIENTO PARA LA PREPARACION DEL MISMO. LOS COMPUESTOS DE FORMULA (I) SON UTILES COMO PRODUCTOS FARMACEUTICOS PARA EL TRATAMIENTO DEL GLAUCOMA Y DE LA MIOPIA.
ES97931793T 1996-07-08 1997-07-07 Derivados de benzo(g)quinolina. Expired - Lifetime ES2170402T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9614282.3A GB9614282D0 (en) 1996-07-08 1996-07-08 Organic compounds
GBGB9626093.0A GB9626093D0 (en) 1996-12-16 1996-12-16 Organic compounds

Publications (1)

Publication Number Publication Date
ES2170402T3 true ES2170402T3 (es) 2002-08-01

Family

ID=26309658

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97931793T Expired - Lifetime ES2170402T3 (es) 1996-07-08 1997-07-07 Derivados de benzo(g)quinolina.

Country Status (28)

Country Link
US (1) US6057334A (es)
EP (1) EP0912553B1 (es)
JP (1) JP4216337B2 (es)
KR (1) KR100491478B1 (es)
CN (1) CN1125065C (es)
AR (1) AR007814A1 (es)
AT (1) ATE211470T1 (es)
AU (1) AU719119B2 (es)
BR (1) BR9710218A (es)
CA (1) CA2257646C (es)
CO (1) CO4870760A1 (es)
CY (1) CY2322B1 (es)
CZ (1) CZ2799A3 (es)
DE (1) DE69709869T2 (es)
DK (1) DK0912553T3 (es)
ES (1) ES2170402T3 (es)
HK (1) HK1020569A1 (es)
ID (1) ID18896A (es)
IL (1) IL127376A (es)
NO (1) NO319401B1 (es)
NZ (1) NZ333311A (es)
PE (1) PE87998A1 (es)
PL (1) PL330723A1 (es)
PT (1) PT912553E (es)
SK (1) SK399A3 (es)
TR (1) TR199900016T2 (es)
TW (1) TW378209B (es)
WO (1) WO1998001444A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20030240A1 (es) * 2001-07-09 2003-04-16 Novartis Ag DERIVADOS DE BENZO [g] QUINOLINA
EG24415A (en) 2002-03-07 2009-05-25 Novartis Ag Quinoline derivatives
ATE438640T1 (de) * 2002-03-07 2009-08-15 Novartis Pharma Gmbh Chinolinderivate und ihre anwendung bei glaukom und kurzsichtigkeit
BRPI0414149A (pt) * 2003-09-05 2006-10-31 Novartis Ag composições compreendendo derivados de benzo(g)-quinolina e derivados de prostaglandina
CN105434439B (zh) * 2015-11-11 2018-07-24 温州医科大学 一种多巴胺d2受体的部分激动剂在制备抑制近视药物上的应用及其使用方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE56958T1 (de) * 1981-10-16 1990-10-15 Sandoz Ag 1,2,3,4,4a,5,10,10a-octahydrobenzo(g)chinolinderivate mit pharmazeutischer wirkung.
AU3879789A (en) * 1988-07-22 1990-02-19 Sandoz Ag Use of benzo(g)quinolines in treatment of nicotine addiction
GB8829330D0 (en) * 1988-12-16 1989-02-01 Sandoz Ltd Improvements in or relating to organic compounds
DE4114325A1 (de) * 1991-05-02 1992-11-05 Sandoz Ag Octahydrobenzo(g)chinolin, seine herstellung und verwendung
US5262422A (en) * 1991-05-02 1993-11-16 Sandoz Ltd. Octahydrobenzo[g]quinoline
GB9326010D0 (en) * 1993-12-21 1994-02-23 Sandoz Ltd Improvements in or relating to organic compounds
FR2729145A1 (fr) * 1995-01-06 1996-07-12 Smithkline Beecham Lab Nouveaux derives d'amine, leur procede de preparation et leur utilisation en tant que medicaments et notamment en tant qu'agents anti-arythmiques

Also Published As

Publication number Publication date
US6057334A (en) 2000-05-02
JP4216337B2 (ja) 2009-01-28
ID18896A (id) 1998-05-20
CZ2799A3 (cs) 1999-03-17
NO319401B1 (no) 2005-08-08
BR9710218A (pt) 1999-08-10
AU3542297A (en) 1998-02-02
AU719119B2 (en) 2000-05-04
IL127376A0 (en) 1999-10-28
KR100491478B1 (ko) 2005-05-27
EP0912553B1 (en) 2002-01-02
DE69709869T2 (de) 2002-08-14
SK399A3 (en) 1999-06-11
CO4870760A1 (es) 1999-12-27
WO1998001444A1 (en) 1998-01-15
CA2257646A1 (en) 1998-01-15
TW378209B (en) 2000-01-01
AR007814A1 (es) 1999-11-24
NZ333311A (en) 2000-06-23
NO990035D0 (no) 1999-01-05
PE87998A1 (es) 1998-12-30
DK0912553T3 (da) 2002-04-22
CY2322B1 (en) 2003-11-14
ATE211470T1 (de) 2002-01-15
CA2257646C (en) 2006-05-09
DE69709869D1 (de) 2002-02-28
PL330723A1 (en) 1999-05-24
EP0912553A1 (en) 1999-05-06
CN1225093A (zh) 1999-08-04
PT912553E (pt) 2002-06-28
TR199900016T2 (xx) 1999-04-21
JP2000514075A (ja) 2000-10-24
IL127376A (en) 2003-12-10
NO990035L (no) 1999-01-05
KR20000023572A (ko) 2000-04-25
HK1020569A1 (en) 2000-05-12
CN1125065C (zh) 2003-10-22

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