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ES2161354T3 - Compuestos mimeticos de la hoja beta y su uso como inhibidores de proteasas. - Google Patents

Compuestos mimeticos de la hoja beta y su uso como inhibidores de proteasas.

Info

Publication number
ES2161354T3
ES2161354T3 ES96910566T ES96910566T ES2161354T3 ES 2161354 T3 ES2161354 T3 ES 2161354T3 ES 96910566 T ES96910566 T ES 96910566T ES 96910566 T ES96910566 T ES 96910566T ES 2161354 T3 ES2161354 T3 ES 2161354T3
Authority
ES
Spain
Prior art keywords
beta
protease inhibitors
beta sheet
mimetic compounds
sheet
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96910566T
Other languages
English (en)
Inventor
Michael Kahn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Molecumetics Ltd
Original Assignee
Molecumetics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Molecumetics Ltd filed Critical Molecumetics Ltd
Application granted granted Critical
Publication of ES2161354T3 publication Critical patent/ES2161354T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/005—Enzyme inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Transplantation (AREA)
  • Cardiology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Vascular Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
  • Materials For Medical Uses (AREA)
  • Paper (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE DESCRIBEN MIMETICOS DE LAMINA RELACIONADOS CON LOS MISMOS PARA IMPARTIR O ESTABILIZAR LA ESTRUCTURA DE LAMINA UN ASPECTO, LOS MIMETICOS DE LAMINA OVALENTE AL EXTREMO O AL INTERIOR DE LA LONGITUD DEL PEPTIDO O LA PROTEINA. LOS MIMETICOS DE LAMINA {BE} POSEEN UTILIDAD COMO INHIBIDORES DE PROTEASAS EN GENERAL, INCLUYENDO ACTIVIDAD COMO INHIBIDORES DE PROTEASAS SERICAS TALES COMO TROMBINA, ELASTASA Y FACTOR X.
ES96910566T 1995-03-24 1996-03-25 Compuestos mimeticos de la hoja beta y su uso como inhibidores de proteasas. Expired - Lifetime ES2161354T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41051895A 1995-03-24 1995-03-24
US54900695A 1995-10-27 1995-10-27

Publications (1)

Publication Number Publication Date
ES2161354T3 true ES2161354T3 (es) 2001-12-01

Family

ID=27021026

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96910566T Expired - Lifetime ES2161354T3 (es) 1995-03-24 1996-03-25 Compuestos mimeticos de la hoja beta y su uso como inhibidores de proteasas.

Country Status (8)

Country Link
EP (2) EP0817642A1 (es)
JP (4) JPH10508034A (es)
AT (1) ATE206433T1 (es)
AU (2) AU713530B2 (es)
CA (2) CA2215720A1 (es)
DE (1) DE69615671T2 (es)
ES (1) ES2161354T3 (es)
WO (1) WO1996030035A1 (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5817757A (en) * 1995-10-30 1998-10-06 Merck & Co., Inc. Inhibitors of peptide binding to MHO class II proteins
US5719296A (en) * 1995-10-30 1998-02-17 Merck & Co., Inc. Pseudopeptide lactam inhibitors of peptide binding to MHC class II proteins
US5840835A (en) * 1995-10-30 1998-11-24 Merck & Co., Inc. Inhibitors of peptide binding to MHC class II proteins
AU7604196A (en) * 1995-10-30 1997-05-22 Merck & Co., Inc. Novel inhibitors of peptide binding to mhc class ii proteins
GB9702377D0 (en) * 1996-02-23 1997-03-26 Zeneca Ltd Peptide derivatives
CA2252417A1 (en) 1996-06-07 1997-12-11 Zeneca Limited Peptide derivatives
AU733562B2 (en) * 1996-06-18 2001-05-17 Warner-Lambert Company Process for the preparation of chiral keto-heterocycles of basic amino acids
EP1661566A3 (en) * 1996-08-05 2008-04-16 Myriad Genetics, Inc. Use of beta-sheet mimetics as protease and kinase inhibitors and as inhibitors of transcription factors
ES2262184T3 (es) * 1996-08-05 2006-11-16 Myriad Genetics, Inc. Utilizacion de mimeticos de hojas beta como inhibidores de proteasa y de kinasa o como inhibidores de factores de transcripcion.
GB9621836D0 (en) 1996-10-19 1996-12-11 Zeneca Ltd Peptide compounds
GB9624562D0 (en) * 1996-11-27 1997-01-15 Zeneca Ltd Peptide derivatives
GB9625865D0 (en) * 1996-12-12 1997-01-29 Zeneca Ltd Peptides
JP2002503674A (ja) * 1998-02-12 2002-02-05 モレキュメティックス リミテッド βシート模倣物およびその使用に関する方法
US6323219B1 (en) 1998-04-02 2001-11-27 Ortho-Mcneil Pharmaceutical, Inc. Methods for treating immunomediated inflammatory disorders
US8093293B2 (en) 1998-07-06 2012-01-10 Johnson & Johnson Consumer Companies, Inc. Methods for treating skin conditions
US8106094B2 (en) 1998-07-06 2012-01-31 Johnson & Johnson Consumer Companies, Inc. Compositions and methods for treating skin conditions
CN1353701A (zh) 1999-01-27 2002-06-12 奥索-麦克尼尔药品公司 用作类胰蛋白酶抑制剂的肽基杂环酮类化合物
US7309688B2 (en) 2000-10-27 2007-12-18 Johnson & Johnson Consumer Companies Topical anti-cancer compositions and methods of use thereof
AU2001245356A1 (en) * 2000-02-29 2001-09-12 Bristol-Myers Squibb Pharma Company Inhibitors of hepatitis c virus ns3 protease
US8431550B2 (en) 2000-10-27 2013-04-30 Johnson & Johnson Consumer Companies, Inc. Topical anti-cancer compositions and methods of use thereof
US7192615B2 (en) 2001-02-28 2007-03-20 J&J Consumer Companies, Inc. Compositions containing legume products
JPWO2011096440A1 (ja) 2010-02-03 2013-06-10 株式会社 ＰＲＩＳＭ ＢｉｏＬａｂ 天然変性タンパク質に結合する化合物およびそのスクリーニング方法
WO2016057413A2 (en) 2014-10-06 2016-04-14 Cortexyme, Inc. Inhibitors of lysine gingipain
EP3374352A4 (en) 2015-11-09 2019-10-02 Cortexyme, Inc. GINGIPAINE ARGININE INHIBITORS
CA3036862A1 (en) 2016-09-16 2018-03-22 Cortexyme, Inc. Ketone inhibitors of lysine gingipain

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA896851B (en) * 1988-09-14 1990-06-27 Hoffmann La Roche Use of ace-inhibitors

Also Published As

Publication number Publication date
JP2004131511A (ja) 2004-04-30
EP0817642A1 (en) 1998-01-14
JP2000319295A (ja) 2000-11-21
AU5372996A (en) 1996-10-16
AU713530B2 (en) 1999-12-02
ATE206433T1 (de) 2001-10-15
WO1996030035A1 (en) 1996-10-03
JP4152900B2 (ja) 2008-09-17
DE69615671D1 (de) 2001-11-08
DE69615671T2 (de) 2002-08-08
EP0815123A1 (en) 1998-01-07
AU5371496A (en) 1996-10-16
CA2215720A1 (en) 1996-10-03
JPH10508035A (ja) 1998-08-04
CA2215695C (en) 2003-09-16
JPH10508034A (ja) 1998-08-04
EP0815123B1 (en) 2001-10-04
AU712581B2 (en) 1999-11-11
CA2215695A1 (en) 1996-10-03

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