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ES2160696T3 - Sales de amonio polimeras reticuladas. - Google Patents

Sales de amonio polimeras reticuladas.

Info

Publication number
ES2160696T3
ES2160696T3 ES95908568T ES95908568T ES2160696T3 ES 2160696 T3 ES2160696 T3 ES 2160696T3 ES 95908568 T ES95908568 T ES 95908568T ES 95908568 T ES95908568 T ES 95908568T ES 2160696 T3 ES2160696 T3 ES 2160696T3
Authority
ES
Spain
Prior art keywords
atoms
ammonium
ammonium salts
alkylene group
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95908568T
Other languages
English (en)
Inventor
Susan Durkee Royce
Garret Daniel Figuly
Nitya Prakash Khasat
Jose Ricardo Matos
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Pharma Co
EIDP Inc
Original Assignee
EI Du Pont de Nemours and Co
DuPont Merck Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by EI Du Pont de Nemours and Co, DuPont Merck Pharmaceutical Co filed Critical EI Du Pont de Nemours and Co
Application granted granted Critical
Publication of ES2160696T3 publication Critical patent/ES2160696T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A61K31/787—Polymers containing nitrogen containing heterocyclic rings having nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/02—Polyamines
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/02—Polyamines
    • C08G73/0206—Polyalkylene(poly)amines
    • C08G73/0213—Preparatory process
    • C08G73/0226—Quaternisation of polyalkylene(poly)amines
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/02—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques
    • C08J3/03—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in aqueous media
    • C08J3/075—Macromolecular gels

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Dispersion Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polyethers (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Medicinal Preparation (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Polyamides (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

SE REVELAN NUEVAS SALES AMONICAS POLIMERICAS ENTRECRUZADAS EN DONDE EN DICHA SAL POLIMERICA: APROXIMADAMENTE EL 25% O MAS DE LOS SEGMENTOS LOS CUALES ENLAZAN ATOMOS DE NITROGENO AMONICO SON DEL GRUPO Y EN DONDE Y ES UN GRUPO N-ALQUILENO O UN GRUPO NALQUILENO SUSTITUIDO DE ALQUILO, EN DONDE DICHO GRUPO N-ALQUILENO TIENE DE 7 HASTA APROXIMADAMENTE 20 ATOMOS DE CARBONO; DEL 0 HASTA APROXIMADAMENTE EL 75% DE LOS SEGMENTOS LOS CUALES ENLAZAN ATOMOS DE NITROGENO AMONICO SON DEL GRUPO Z EN DONDE Z ES UN RADICAL HIDROCARBILENO QUE CONTIENE 2 O MAS ATOMOS DE CARBONO, DICHO RADICAL HIDROCARBILENO OPCIONALMENTE CONTIENE UNO O MAS GRUPOS HIDROXILO, ETER, AMINO, TIOETER, CETO O SILILO O ANILLOS HETEROCICLICOS; Y APROXIMADAMENTE EL 25% O MAS DE LOS ATOMOS AMONICOS SON ATOMOS AMONICOS SECUNDARIOS.
ES95908568T 1994-01-18 1995-01-18 Sales de amonio polimeras reticuladas. Expired - Lifetime ES2160696T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18295494A 1994-01-18 1994-01-18
US08/202,395 US5556619A (en) 1992-08-20 1994-02-24 Crosslinked polymeric ammonium salts

Publications (1)

Publication Number Publication Date
ES2160696T3 true ES2160696T3 (es) 2001-11-16

Family

ID=26878587

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95908568T Expired - Lifetime ES2160696T3 (es) 1994-01-18 1995-01-18 Sales de amonio polimeras reticuladas.

Country Status (24)

Country Link
US (2) US5556619A (es)
EP (1) EP0740679B1 (es)
JP (1) JPH09507687A (es)
KR (1) KR970700714A (es)
CN (1) CN1143379A (es)
AT (1) ATE204005T1 (es)
AU (1) AU682930B2 (es)
BR (1) BR9506636A (es)
CA (1) CA2179712C (es)
CZ (1) CZ194396A3 (es)
DE (1) DE69522095T2 (es)
DK (1) DK0740679T3 (es)
ES (1) ES2160696T3 (es)
FI (1) FI962881A0 (es)
GR (1) GR3036589T3 (es)
HR (1) HRP950024A2 (es)
HU (1) HUT75944A (es)
IL (1) IL112343A0 (es)
NO (1) NO962985L (es)
NZ (1) NZ279647A (es)
PL (1) PL315580A1 (es)
PT (1) PT740679E (es)
SK (1) SK93696A3 (es)
WO (1) WO1995019384A1 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA95390B (en) * 1994-01-18 1996-07-18 Du Pont Crosslinked polymeric ammonium salts
US5925379A (en) * 1997-03-27 1999-07-20 Geltex Pharmaceuticals, Inc. Interpenetrating polymer networks for sequestration of bile acids
US6083497A (en) * 1997-11-05 2000-07-04 Geltex Pharmaceuticals, Inc. Method for treating hypercholesterolemia with unsubstituted polydiallylamine polymers
US6271264B1 (en) * 1998-12-01 2001-08-07 Geltex Pharmaceuticals, Inc. Polymers containing spirobicyclic ammonium moieties as bile acid sequestrants
WO2000038664A2 (en) * 1998-12-23 2000-07-06 Geltex Pharmaceuticals, Inc. Amine condensation polymer bile acid sequestrants
WO2002066015A1 (en) 2001-02-16 2002-08-29 Bristol-Myers Squibb Pharma Company Use of polyalkylamine polymers in controlled release devices
DE60317579T2 (de) * 2003-09-23 2008-09-18 Akciju Sabiedriba "Olainfarm" Polymere 3,5-dimethyl-1-adamantylammoniumsalze und deren verwendung in form von virustatika
US7767768B2 (en) 2003-11-03 2010-08-03 Ilypsa, Inc. Crosslinked amine polymers
US7335795B2 (en) 2004-03-22 2008-02-26 Ilypsa, Inc. Crosslinked amine polymers
US7608674B2 (en) 2003-11-03 2009-10-27 Ilypsa, Inc. Pharmaceutical compositions comprising cross-linked small molecule amine polymers
WO2011106542A2 (en) * 2010-02-24 2011-09-01 Relypsa, Inc. Crosslinked polyvrnylamine, poly all ylamine, and polyethyleneimine for use as bile acid sequestrants
CN104168988A (zh) * 2011-08-01 2014-11-26 株式会社新生能源研究 Co2促进传送膜及其制造方法
EP2782948B1 (de) * 2011-11-25 2016-06-08 Basf Se Lipophile polyalkylenpolyamine durch homogen-katalysierte alkohol-aminierung
KR101631151B1 (ko) * 2014-05-22 2016-06-27 한국과학기술연구원 탄화수소계열 전해질 고분자 합성 방법 및 이에 사용되는 중합 용매
PT3593808T (pt) * 2014-12-10 2021-02-11 Tricida Inc Polímeros de ligação a protões para administração oral
CN113583256B (zh) * 2021-07-05 2022-10-25 南京理工大学 一种阳离子水凝胶材料的制备方法

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3383281A (en) * 1961-09-22 1968-05-14 Merck & Co Inc Method for binding bile acids in vivo
US3332841A (en) * 1961-10-04 1967-07-25 Lilly Co Eli Method of treating hyperacidity
US3499960A (en) * 1965-01-25 1970-03-10 Merck & Co Inc Palatable coated particles of an anion exchange resin
US3803237A (en) * 1969-11-03 1974-04-09 Upjohn Co Reaction products of polyethylenepolyamines and chlorohydrins or epoxy containing compounds
NL7017227A (es) * 1969-12-27 1971-06-29
US3778476A (en) * 1970-05-11 1973-12-11 California Inst Of Techn Polymeric organic halogen salts
US3692895A (en) * 1970-09-08 1972-09-19 Norman A Nelson Method of reducing hypercholesteremia in humans employing a copolymer of polyethylenepolyamine and a bifunctional substance, such as epichlorohydria
US3980770A (en) * 1971-06-04 1976-09-14 Pharmacia Aktiebolag Polymerization products containing amino groups useful in serum cholesterol level control
US3974272A (en) * 1972-09-01 1976-08-10 Merck & Co., Inc. Palatable cholestyramine coacervate compositions
US4205064A (en) * 1973-06-11 1980-05-27 Merck & Co., Inc. Bile acid sequestering composition containing poly[{alkyl-(3-ammoniopropyl)imino}-trimethylenedihalides]
US4027009A (en) * 1973-06-11 1977-05-31 Merck & Co., Inc. Compositions and methods for depressing blood serum cholesterol
US4147586A (en) * 1974-09-14 1979-04-03 Monsanto Company Cellulosic paper containing the reaction product of a dihaloalkane alkylene diamine adduct and epihalohydrin
US4071478A (en) * 1976-06-07 1978-01-31 Merck & Co., Inc. Controlled partially cross-linked 3,3-ionenes
JPS5566513A (en) * 1978-11-14 1980-05-20 Ono Pharmaceut Co Ltd Drug for arteriosclerosis comprising high polymer compound as active constituent
US4374244A (en) * 1979-04-13 1983-02-15 Kewanee Industries, Inc. Linear quaternary ammonium polymers
US4439419A (en) * 1980-02-20 1984-03-27 The Upjohn Company Method of treating gastric hyperacidity in humans employing a copolymer of polyethylenepolyamine and a bifunctional substance as epichlorhydrin
JPS5879022A (ja) * 1981-11-04 1983-05-12 Bitamin Kenkyusho:Kk 第四級窒素原子を含有する新規な金属架橋高分子化合物、その製法及び該高分子化合物を有効成分とする高脂血症治療剤
US4604430A (en) * 1984-05-11 1986-08-05 Bristol-Myers Company Novel bile sequestrant resin
SU1249031A1 (ru) * 1984-10-15 1986-08-07 Иркутский институт органической химии СО АН СССР Способ получени полиионенов
US4593073A (en) * 1985-04-23 1986-06-03 The Royal Institution For The Advancement Of Learing (Mcgill Univ.) Polymer resins with amino acid containing pendants for sorption of bile pigments and bile acids
IT1188184B (it) * 1985-08-14 1988-01-07 Texcontor Ets Sali ammonici quaternari di polisaccaridi ad attivita' ipocolesterolemizzante
DE3609984A1 (de) * 1986-03-25 1987-10-01 Bayer Ag Verfahren zur behandlung von fasermaterialien
US4877775A (en) * 1986-06-16 1989-10-31 E. I. Du Pont De Nemours And Company Polymeric aminosaccharides as antihypercholesterolemic agents
IT1223362B (it) * 1987-11-20 1990-09-19 Texcontor Ets Derivati cationizzati polisaccaridi ad attivita' ipocolesterolemizzante
GB8913823D0 (en) * 1989-06-15 1989-08-02 Smith Kline French Lab Compounds
GB8829088D0 (en) * 1988-12-13 1989-01-25 Smith Kline French Lab Compounds
GB8829835D0 (en) * 1988-12-21 1989-02-15 Smith Kline French Lab Compounds
GB8904489D0 (en) * 1989-02-28 1989-04-12 Smith Kline French Lab Compounds
IT1229133B (it) * 1989-03-09 1991-07-22 Farmhispania Sali ammonici di policiclodestrine per l'impiego come agenti ipocolesterolemizzanti
IT1229754B (it) * 1989-05-17 1991-09-10 Farmhispania Procedimento per la preparazione del chitosano e di suoi derivati contenenti gruppi di ammonio quaternario
GB8911719D0 (en) * 1989-05-22 1989-07-05 Smith Kline French Lab Compounds
GB8912903D0 (en) * 1989-06-05 1989-07-26 Smith Kline French Lab Compounds
GB8913700D0 (en) * 1989-06-14 1989-08-02 Smith Kline French Lab Compounds
GB8913699D0 (en) * 1989-06-14 1989-08-02 Smith Kline French Lab Compounds
US5236701A (en) * 1989-07-19 1993-08-17 Lowchol Scientific Inc. Ingestible hydrophilic polymeric amines useful for lowering blood cholesterol
GB8928278D0 (en) * 1989-12-14 1990-02-21 Smith Kline French Lab Compounds
CA2040996A1 (en) * 1990-05-02 1991-11-03 Robert L. Albright Composition and method for controlling cholesterol
US5091175A (en) * 1990-05-14 1992-02-25 Erbamont Inc. Pharmaceutical composition containing bile acid sequestrant enclosed in a size-exclusion membrane
GB9011332D0 (en) * 1990-05-21 1990-07-11 Smith Kline French Lab Compounds
CA2042870C (en) * 1991-05-17 1996-11-26 Leon Edward St. Pierre Metal ion coordinated polyamine resins for the lowering of blood cholesterol
CA2142826A1 (en) * 1992-08-20 1994-03-03 Garret D. Figuly Crosslinked polymeric ammonium salts

Also Published As

Publication number Publication date
KR970700714A (ko) 1997-02-12
BR9506636A (pt) 1997-09-16
NO962985L (no) 1996-09-17
PT740679E (pt) 2001-11-30
IL112343A0 (en) 1995-03-30
CN1143379A (zh) 1997-02-19
FI962881A (fi) 1996-07-17
JPH09507687A (ja) 1997-08-05
CA2179712A1 (en) 1995-07-20
HRP950024A2 (en) 1997-06-30
DE69522095D1 (de) 2001-09-13
AU1683495A (en) 1995-08-01
FI962881A0 (fi) 1996-07-17
EP0740679B1 (en) 2001-08-08
PL315580A1 (en) 1996-11-12
CZ194396A3 (en) 1997-07-16
NO962985D0 (no) 1996-07-17
EP0740679A1 (en) 1996-11-06
DK0740679T3 (da) 2001-10-22
NZ279647A (en) 1998-06-26
DE69522095T2 (de) 2002-03-28
US5726284A (en) 1998-03-10
AU682930B2 (en) 1997-10-23
US5556619A (en) 1996-09-17
GR3036589T3 (en) 2001-12-31
HU9601950D0 (en) 1996-09-30
HUT75944A (en) 1997-05-28
SK93696A3 (en) 1997-04-09
WO1995019384A1 (en) 1995-07-20
ATE204005T1 (de) 2001-08-15
CA2179712C (en) 2001-11-27

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