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ES2155898T3 - Derivados de azepina tetraciclica sustituidos, que presentan una afinidad por los receptores 5-ht2. - Google Patents

Derivados de azepina tetraciclica sustituidos, que presentan una afinidad por los receptores 5-ht2.

Info

Publication number
ES2155898T3
ES2155898T3 ES95937006T ES95937006T ES2155898T3 ES 2155898 T3 ES2155898 T3 ES 2155898T3 ES 95937006 T ES95937006 T ES 95937006T ES 95937006 T ES95937006 T ES 95937006T ES 2155898 T3 ES2155898 T3 ES 2155898T3
Authority
ES
Spain
Prior art keywords
sup
sub
rent
hydrogen
trifluometilo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95937006T
Other languages
English (en)
Inventor
Victor Karel Sipido
Francisco Javi Fernandez-Gadea
Jose Ignacio Andres-Gil
Theo Frans Meert
Pilar Gil-Lopetegui
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Original Assignee
Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Application granted granted Critical
Publication of ES2155898T3 publication Critical patent/ES2155898T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
    • C07D223/20—Dibenz [b, e] azepines; Hydrogenated dibenz [b, e] azepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Addiction (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

ESTA INVENCION SE REFIERE A LOS COMPUESTOS DE FORMULA (I), A LAS SALES FARMACEUTICAMENTE ACEPTABLES Y A LAS FORMAS ESTEREOISOMERICAS DE LOS MISMOS, Y ADEMAS A LAS FORMAS N-OXIDAS DE LOS MISMO. EN LA FORMULA (I) R{SUP,1} Y R{SUP,2} SON CADA UNO INDEPENDIENTEMENTE HIDROGENO; C{SUB,1-6}ALQUILO; C{SUB,16}ALQUILCARBONILO; TRIHALOMETILCARBONILO; C{SUB,1-6}ALQUILO SUSTITUIDO CON HIDROXIDO, C{SUB,1-6}ALQUILOXI, CARBOXILO, C{SUB,1-6}ALQUILCARBONILOXI, C{SUB,1-6}ALQUILOXICARBONILO O ARILO; O R{SUP,1} Y R{SUP,2} TOMADOS JUNTO CON EL ATOMO DE NITROGENO AL QUE ESTAN INCORPORADOS PUEDEN FORMAR UN ANILLO DE MORFOLINILO O UN HETEROCICLILO OPCIONALMENTE SUSTITUIDO; R{SUP,3}, R{SUP,4}, R{SUP,5}, R{SUP,6}, R{SUP,9}, R{SUP,10}, R{SUP,11} O R{SUP,12} CADA UNO INDEPENDIENTEMENTE SON HIDROGENO, HALO, CIANO, HIDROXIDO, TRIFLUOMETILO, TRIFLUOMETOXI, CARBOXILO, NITRO, AMINO, MONO- O DI(()C{SUB,1-6}ALQUILO())-AMINO, C{SUB,16}ALQUILCARBONILAMINO, AMINOSULFONILO, MONO- O DI(()C{SUB,16}ALQUILO())-AMINOSULFONILO, C{SUB,1-6}ALQUILO, C{SUB,16}ALQUILOXI, C{SUB,1-6}ALQUILCARBONILO, C{SUB,1-6}ALQUILOXICARBONILO; R{SUP,7} Y R{SUP,8} SON CADA UNO INDEPENDIENTEMENTE HIDROGENO, HIDROXIDO, C{SUB,1-6}ALQUILO, C{SUB,1-6}ALQUILOXI O R{SUP,7} Y R{SUP,8} TOMADOS JUNTOS PUEDEN FORMAR MONO- O DI(CIANO)METILENO, O JUNTO CON EL ATOMO DE CARBONO AL QUE ESTAN INCORPORADOS FORMAN UN SUSTITUYENTE DE CARBONILO O ESPIRO; O R{SUP,7} Y R{SUP,8} TOMADOS JUNTOS PUEDEN FORMAR METILENO; R{SUP,13} ES HIDROGENO, C{SUB,1-6}ALQUILO, O TRIFLUOMETILO; R{SUP,14} ES HIDROGENO, C{SUB,1-6}ALQUILO, CIANO, O TRIFLUOMETILO; N ES CERO A 6. ESTOS COMPUESTOS FUERON COMPROBADOS COMO ANTAGONISTAS MCPP EN RATAS. LOS COMPUESTOS DE FORMULA (I) PUEDEN SER UTILIZADOS COMO AGENTES TERAPEUTICOS EN EL TRATAMIENTO O LA PREVENCION DE TRASTORNOS DEL SNC, TRASTORNOS CARDIOVASCULARES O TRASTORNOS GASTROINTESTINALES.
ES95937006T 1994-11-02 1995-10-25 Derivados de azepina tetraciclica sustituidos, que presentan una afinidad por los receptores 5-ht2. Expired - Lifetime ES2155898T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP94203178 1994-11-02
US08/457,968 US5552399A (en) 1994-11-02 1995-05-31 Substituted tetracyclic azepine derivatives

Publications (1)

Publication Number Publication Date
ES2155898T3 true ES2155898T3 (es) 2001-06-01

Family

ID=8217337

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95937006T Expired - Lifetime ES2155898T3 (es) 1994-11-02 1995-10-25 Derivados de azepina tetraciclica sustituidos, que presentan una afinidad por los receptores 5-ht2.

Country Status (30)

Country Link
US (1) US5552399A (es)
EP (1) EP0789701B1 (es)
JP (1) JP3818541B2 (es)
KR (1) KR100392060B1 (es)
CN (1) CN1085667C (es)
AR (1) AR002238A1 (es)
AT (1) ATE199087T1 (es)
AU (1) AU704285B2 (es)
BR (1) BR9509552A (es)
CA (1) CA2203661A1 (es)
CZ (1) CZ286945B6 (es)
DE (1) DE69520070T2 (es)
DK (1) DK0789701T3 (es)
ES (1) ES2155898T3 (es)
FI (1) FI113050B (es)
GR (1) GR3035680T3 (es)
HR (1) HRP950537A2 (es)
HU (1) HUT77408A (es)
IL (1) IL115819A (es)
MY (1) MY113325A (es)
NO (1) NO308035B1 (es)
NZ (1) NZ295656A (es)
PL (1) PL183686B1 (es)
PT (1) PT789701E (es)
RU (1) RU2163240C2 (es)
SI (1) SI0789701T1 (es)
TR (1) TR199501356A2 (es)
TW (1) TW349950B (es)
WO (1) WO1996014320A1 (es)
ZA (1) ZA959215B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997039001A1 (en) * 1996-04-12 1997-10-23 Janssen Pharmaceutica N.V. Isoxazolidine derivatives
UA52778C2 (uk) * 1997-10-10 2003-01-15 Янссен Фармацевтика Н.В. Галогенозаміщені тетрациклічні похідні тетрагідрофурану, спосіб їх отримання та композиція на їх основі
HRP20020305A8 (en) 2002-04-10 2009-03-31 GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. 2-thia-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof
HRP20030885A2 (en) * 2003-11-03 2005-08-31 Pliva-Istra�iva�ki institut d.o.o. USE OF 2-THIA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYYTEM DISEASES AND DISORDERS
HRP20030953A2 (en) * 2003-11-21 2005-10-31 Pliva-Istra�iva�ki institut d.o.o. PREPARATION OF 1-AZA-2-OXA-DIBENZO[e,h]AZULENES AND THEIR USE FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS
CN110996932A (zh) * 2017-07-13 2020-04-10 托尼克斯医药控股公司 环苯扎林和阿米替林的类似物

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT338799B (de) * 1974-03-02 1977-09-12 Boehringer Sohn Ingelheim Verfahren zur herstellung neuer substituierter 6-aryl-4h-s-triazolo-(3,4c)-thieno-(2,3e)-1,4-diazepine und ihrer salze
NL7414038A (nl) * 1974-10-28 1976-05-03 Akzo Nv Nieuwe tetracyclische pyrrolidino derivaten.
DE2647114A1 (de) * 1975-10-21 1977-05-05 Hans Fickler Vorrichtung zur erzeugung einer laengsbewegung
JPS5572177A (en) * 1978-11-27 1980-05-30 Shionogi & Co Ltd 4,1-benzoxazepine or 4,1-benzothiazepine
TW206227B (es) * 1989-10-05 1993-05-21 Sankyo Co
US5512563A (en) * 1993-07-29 1996-04-30 American Cyanamid Company Tricyclic benzazepine vasopressin antagonists

Also Published As

Publication number Publication date
FI113050B (fi) 2004-02-27
US5552399A (en) 1996-09-03
IL115819A (en) 1998-10-30
HUT77408A (hu) 1998-04-28
MX9703255A (es) 1997-07-31
KR100392060B1 (ko) 2003-11-28
EP0789701B1 (en) 2001-02-07
NO308035B1 (no) 2000-07-10
ZA959215B (en) 1997-04-30
CZ132397A3 (cs) 1998-01-14
ATE199087T1 (de) 2001-02-15
NO972017D0 (no) 1997-04-30
DE69520070T2 (de) 2001-09-13
TW349950B (en) 1999-01-11
NZ295656A (en) 1998-10-28
FI971854A (fi) 1997-04-30
AU3924995A (en) 1996-05-31
NO972017L (no) 1997-04-30
RU2163240C2 (ru) 2001-02-20
MY113325A (en) 2002-01-31
HRP950537A2 (en) 1997-08-31
PL183686B1 (pl) 2002-06-28
PL319939A1 (en) 1997-09-01
SI0789701T1 (en) 2001-08-31
FI971854A0 (fi) 1997-04-30
WO1996014320A1 (en) 1996-05-17
BR9509552A (pt) 1997-09-16
CN1085667C (zh) 2002-05-29
CN1162313A (zh) 1997-10-15
AR002238A1 (es) 1998-03-11
IL115819A0 (en) 1996-01-19
PT789701E (pt) 2001-07-31
TR199501356A2 (tr) 1996-06-21
AU704285B2 (en) 1999-04-15
DK0789701T3 (da) 2001-06-18
EP0789701A1 (en) 1997-08-20
CA2203661A1 (en) 1996-05-17
DE69520070D1 (de) 2001-03-15
CZ286945B6 (en) 2000-08-16
GR3035680T3 (en) 2001-06-29
JPH10508308A (ja) 1998-08-18
JP3818541B2 (ja) 2006-09-06

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