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ES2147616T3 - Derivados de piperidina con actividad antagonista del paf. - Google Patents

Derivados de piperidina con actividad antagonista del paf.

Info

Publication number
ES2147616T3
ES2147616T3 ES95932668T ES95932668T ES2147616T3 ES 2147616 T3 ES2147616 T3 ES 2147616T3 ES 95932668 T ES95932668 T ES 95932668T ES 95932668 T ES95932668 T ES 95932668T ES 2147616 T3 ES2147616 T3 ES 2147616T3
Authority
ES
Spain
Prior art keywords
paf
pct
piperidine
derivatives
antagonist activity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95932668T
Other languages
English (en)
Inventor
Elena Carceller
Pere J Jimenez
Nuria Recasens
Jordi Salas
Carmen Almansa
Javier Bartroli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Noucor Health SA
Original Assignee
J Uriach y Cia SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by J Uriach y Cia SA filed Critical J Uriach y Cia SA
Application granted granted Critical
Publication of ES2147616T3 publication Critical patent/ES2147616T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

COMPUESTOS DE FORMULA GENERAL (I) Y SUS SALES Y SOLVATOS SON ANTAGONISTAS PAF Y COMO TALES SON UTILES EN EL TRATAMIENTO DE VARIAS ENFERMEDADES O TRASTORNOS TRANSMITIDOS POR PAF. TAMBIEN SE PROPORCIONAN COMPOSICIONES FARMACEUTICAS QUE INCLUYEN ESTOS COMPUESTOS Y PROCEDIMIENTOS PARA SU PREPARACION.
ES95932668T 1994-11-07 1995-09-05 Derivados de piperidina con actividad antagonista del paf. Expired - Lifetime ES2147616T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES09402291A ES2087038B1 (es) 1994-11-07 1994-11-07 Nuevas piperidinas con actividad antagonista del paf.

Publications (1)

Publication Number Publication Date
ES2147616T3 true ES2147616T3 (es) 2000-09-16

Family

ID=8287905

Family Applications (2)

Application Number Title Priority Date Filing Date
ES09402291A Expired - Fee Related ES2087038B1 (es) 1994-11-07 1994-11-07 Nuevas piperidinas con actividad antagonista del paf.
ES95932668T Expired - Lifetime ES2147616T3 (es) 1994-11-07 1995-09-05 Derivados de piperidina con actividad antagonista del paf.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES09402291A Expired - Fee Related ES2087038B1 (es) 1994-11-07 1994-11-07 Nuevas piperidinas con actividad antagonista del paf.

Country Status (13)

Country Link
US (1) US5705504A (es)
EP (1) EP0738269B1 (es)
JP (1) JP4018137B2 (es)
KR (1) KR100514201B1 (es)
AT (1) ATE192152T1 (es)
AU (1) AU3563695A (es)
DE (1) DE69516503T2 (es)
DK (1) DK0738269T5 (es)
ES (2) ES2087038B1 (es)
GR (1) GR3033528T3 (es)
NO (1) NO306345B1 (es)
PT (1) PT738269E (es)
WO (1) WO1996014317A1 (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2204747C (en) * 1995-09-08 2009-05-05 Elena Carceller New azo derivatives of 5-aminosalicylic acid
ES2165803B1 (es) * 2000-04-10 2003-09-16 Uriach & Cia Sa J Nueva sal de un derivado azo del acido 5-aminosalicilico
GB0013060D0 (en) 2000-05-31 2000-07-19 Astrazeneca Ab Chemical compounds
JP2004516237A (ja) 2000-06-21 2004-06-03 ブリストル−マイヤーズ・スクイブ・ファーマ・カンパニー ケモカイン受容体活性調節剤としてのピペリジンアミド類
AU7931301A (en) * 2000-08-04 2002-02-18 Dmi Biosciences Inc Method of using diketopiperazines and composition containing them
GB0021670D0 (en) 2000-09-04 2000-10-18 Astrazeneca Ab Chemical compounds
GB0117899D0 (en) 2001-07-23 2001-09-12 Astrazeneca Ab Chemical compounds
NZ576931A (en) 2003-05-15 2010-12-24 Dmi Biosciences Inc Treatment of T-cell mediated diseases
FR2860514A1 (fr) * 2003-10-03 2005-04-08 Sanofi Synthelabo Derives d'arylalkylcarbamates, leur preparation et leur application en therapeutique
US20070213311A1 (en) * 2006-03-02 2007-09-13 Yun-Long Li Modulators of 11-beta hydroxyl steroid dehydrogenase type 1, pharmaceutical compositions thereof, and methods of using the same
US7678785B2 (en) 2006-07-24 2010-03-16 Ucb Pharma S.A. Substituted aniline derivatives
KR100737397B1 (ko) 2007-01-31 2007-07-09 한국교세라정공(주) 밀링 커터
EP2300011A4 (en) 2008-05-27 2012-06-20 Dmi Life Sciences Inc METHODS AND THERAPEUTIC COMPOUNDS
FR2962649A1 (fr) 2010-07-19 2012-01-20 Conservatoire Nat Arts Et Metiers Traitement d'une pathologie liee a un effet excessif du tnf par un compose de benzene sulfonamide
GB201101517D0 (en) * 2011-01-28 2011-03-16 Proximagen Ltd Receptor antagonists
CA2846464A1 (en) 2011-10-10 2013-04-18 Ampio Pharmaceuticals, Inc. Implantable medical devices with increased immune tolerance, and methods for making and implanting
MX362164B (es) 2011-10-10 2019-01-07 Ampio Pharmaceuticals Inc Tratamiento de enfermedad de articulacion degenerativa.
KR20140095479A (ko) 2011-10-28 2014-08-01 앰피오 파마슈티컬스 인코퍼레이티드 비염의 치료
US9808454B2 (en) 2013-03-15 2017-11-07 Ampio Pharmaceuticals, Inc. Compositions for the mobilization, homing, expansion and differentiation of stem cells and methods of using the same
KR20170045274A (ko) 2014-08-18 2017-04-26 앰피오 파마슈티컬스 인코퍼레이티드 관절 징후의 치료
US11389512B2 (en) 2015-06-22 2022-07-19 Ampio Pharmaceuticals, Inc. Use of low molecular weight fractions of human serum albumin in treating diseases

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3066434D1 (en) * 1979-11-21 1984-03-08 Kyowa Hakko Kogyo Kk Novel piperidine derivatives, method for the preparation thereof and pharmaceutical compositions containing them
IL85700A0 (en) * 1987-03-24 1988-08-31 Takeda Chemical Industries Ltd 1,4-disubstituted piperazine compounds,their production and use
EP0441226A1 (en) * 1990-01-29 1991-08-14 J. URIACH & CIA. S.A. (cyanomethyl)pyridines useful as PAF antagonists
GB9102997D0 (en) * 1991-02-13 1991-03-27 Pfizer Ltd Therapeutic agents
ES2036926B1 (es) * 1991-08-08 1994-01-16 Uriach & Cia Sa J "procedimiento para la obtencion de derivados de la (2-alquil-3-piridil)metilpiperazina".
US5268376A (en) * 1991-09-04 1993-12-07 Minnesota Mining And Manufacturing Company 1-substituted 1H-imidazo[4,5-c]quinolin-4-amines
US5283242A (en) * 1991-10-24 1994-02-01 American Home Products Corporation Substituted benzimidazoles and quinazolines as antihypertensives

Also Published As

Publication number Publication date
US5705504A (en) 1998-01-06
WO1996014317A1 (en) 1996-05-17
NO962855D0 (no) 1996-07-05
GR3033528T3 (en) 2000-09-29
ES2087038A1 (es) 1996-07-01
JPH09507862A (ja) 1997-08-12
ATE192152T1 (de) 2000-05-15
MX9602559A (es) 1997-07-31
EP0738269A1 (en) 1996-10-23
DK0738269T3 (da) 2000-08-28
DE69516503T2 (de) 2001-03-15
DK0738269T5 (da) 2000-12-18
EP0738269B1 (en) 2000-04-26
PT738269E (pt) 2000-08-31
DE69516503D1 (de) 2000-05-31
ES2087038B1 (es) 1997-03-16
NO962855L (no) 1996-07-05
KR100514201B1 (ko) 2005-12-29
NO306345B1 (no) 1999-10-25
AU3563695A (en) 1996-05-31
JP4018137B2 (ja) 2007-12-05

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