[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

ES2038074B1 - Procedimiento para la preparacion de nuevos derivados de benzimidazol. - Google Patents

Procedimiento para la preparacion de nuevos derivados de benzimidazol.

Info

Publication number
ES2038074B1
ES2038074B1 ES9101740A ES9101740A ES2038074B1 ES 2038074 B1 ES2038074 B1 ES 2038074B1 ES 9101740 A ES9101740 A ES 9101740A ES 9101740 A ES9101740 A ES 9101740A ES 2038074 B1 ES2038074 B1 ES 2038074B1
Authority
ES
Spain
Prior art keywords
radical
aryl
halogen
represent
values
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES9101740A
Other languages
English (en)
Other versions
ES2038074A1 (es
Inventor
Altisent M Rosa Cuberes
Constansa Jordi Frigola
Corominas Juan Pares
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Esteve Pharmaceuticals SA
Original Assignee
Laboratorios del Dr Esteve SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorios del Dr Esteve SA filed Critical Laboratorios del Dr Esteve SA
Publication of ES2038074A1 publication Critical patent/ES2038074A1/es
Application granted granted Critical
Publication of ES2038074B1 publication Critical patent/ES2038074B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTOS PARA LA PREPARACION DE NUEVOS DERIVADOS DE BENZIMIDAZOL. UN PROCEDIMIENTO PARA LA PREPARACION DE NUEVOS DERIVADOS DE BENZIMIDAZOL DE FORMULA GENERAL I, Y SUS SALES TERAPEUTICAMENTE ACEPTABLES CONSISTE EN LA REACCION DE UN COMPUESTO DE FORMULA GENERAL IIA CON UN COMPUESTO DE FORMULA GENERAL III. OTRO PROCEDIMIENTO CONSISTE EN LA REACCION DE UN COMPUESTO DE FORMULA GENERAL IIA, EN LA CUAL A REPRESENTA UN RADICAL NHSI2, CON EL 2,5-DIMETOXITETRAHIDROFURANO. LOS DERIVADOS OBTENIDOS SE UTILIZAN PARA LA FABRICACION DE MEDICAMENTOS DESTINADOS A LA PROFILAXIS Y AL TRATAMIENTO DE DIVERSAS ENFERMEDADES ALERGICAS PROVOCADAS POR LA HISTAMINA.
ES9101740A 1990-07-26 1991-07-25 Procedimiento para la preparacion de nuevos derivados de benzimidazol. Expired - Fee Related ES2038074B1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9009563A FR2665161B1 (fr) 1990-07-26 1990-07-26 Nouveaux derives de benzimidazole, leur preparation et leur application en tant que medicaments.

Publications (2)

Publication Number Publication Date
ES2038074A1 ES2038074A1 (es) 1993-07-01
ES2038074B1 true ES2038074B1 (es) 1994-02-01

Family

ID=9399131

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9101740A Expired - Fee Related ES2038074B1 (es) 1990-07-26 1991-07-25 Procedimiento para la preparacion de nuevos derivados de benzimidazol.

Country Status (25)

Country Link
US (1) US5182280A (es)
EP (1) EP0468884B1 (es)
JP (1) JPH0832703B2 (es)
KR (1) KR0183028B1 (es)
CN (1) CN1030915C (es)
AT (1) ATE131822T1 (es)
AU (1) AU638857B2 (es)
CA (1) CA2047880A1 (es)
CZ (1) CZ280185B6 (es)
DE (1) DE69115588T2 (es)
DK (1) DK0468884T5 (es)
ES (1) ES2038074B1 (es)
FR (1) FR2665161B1 (es)
GR (1) GR3019352T3 (es)
HU (2) HU215109B (es)
MX (1) MX9100377A (es)
NO (1) NO178576C (es)
NZ (1) NZ239104A (es)
PL (1) PL167222B1 (es)
PT (1) PT98409B (es)
RO (1) RO109736B1 (es)
RU (1) RU2024519C1 (es)
TW (1) TW314518B (es)
YU (1) YU48077B (es)
ZA (1) ZA915839B (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2674856B1 (fr) * 1991-04-05 1993-07-30 Esteve Labor Dr Nouveaux antihistaminiques non sedatifs, derives de benzimidazole, leur procede de preparation et leur utilisation en tant que medicaments.
FR2701260B1 (fr) * 1993-02-05 1995-05-05 Esteve Labor Dr Dérivés de 2-[4-(4-azolylbutyl)-1-pipérazinyl]-5-hydroxypyrimidine, leur préparation et leur application en tant que médicaments.
US5681954A (en) * 1993-05-14 1997-10-28 Daiichi Pharmaceutical Co., Ltd. Piperazine derivatives
JP3338913B2 (ja) * 1993-06-29 2002-10-28 大鵬薬品工業株式会社 テトラゾール誘導体
IL113472A0 (en) 1994-04-29 1995-07-31 Lilly Co Eli Non-peptidyl tachykinin receptor antogonists
FR2727865B1 (fr) * 1994-12-08 1997-07-18 Esteve Labor Dr Utilisation des derives de 2-(4-(azolybutyl)-piperazinyl- (methyl))-benzimidazole et analogues ainsi que de leurs sels, pour la preparation de medicaments destines au traitement ou a la prophylaxie de l'asthme
FR2731618B1 (fr) * 1995-03-14 1997-08-01 Esteve Labor Dr Composition ophtalmique topique comprenant un derive de 2-(4-(azolylbutyl)-piperazinyl-methyl)-benzimidazole, notamment pour le traitement de la conjonctivite allergique
AU4005300A (en) * 1999-03-03 2000-09-21 Merck & Co., Inc. Inhibitors of prenyl-protein transferase
US7022728B2 (en) 2001-03-09 2006-04-04 Abbott Laboratories Benzimidazoles that are useful in treating male sexual dysfunction
US20020169166A1 (en) * 2001-03-09 2002-11-14 Cowart Marlon D. Benzimidazoles that are useful in treating sexual dysfunction
US6960589B2 (en) 2001-03-09 2005-11-01 Abbott Laboratories Benzimidazoles that are useful in treating sexual dysfunction
WO2003101994A1 (en) * 2002-05-29 2003-12-11 Abbott Laboratories Fused bicyclic aromatic compounds that are useful in treating sexual dysfunction
US7057042B2 (en) 2002-05-29 2006-06-06 Abbott Laboratories Fused bicyclic aromatic compounds that are useful in treating sexual dysfunction
US6974815B2 (en) * 2002-10-11 2005-12-13 Bristol-Myers Squibb Company Hexahydro-benzimidazolone compounds useful as anti-inflammatory agents
AU2005226729B2 (en) * 2004-03-25 2010-01-28 Janssen Pharmaceutica N.V. Imidazole compounds
CN101089000B (zh) * 2006-06-16 2011-01-05 北京大学 螺环哌嗪季铵盐类化合物及其制备方法和应用
JP5820822B2 (ja) * 2010-04-26 2015-11-24 大日本住友製薬株式会社 リン酸塩を用いる第四級アンモニウム塩の製造法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL272996A (es) * 1960-12-28
US4200641A (en) * 1976-12-21 1980-04-29 Janssen Pharmaceutica, N.V. 1-[(Heterocyclyl)-alkyl]-4-diarylmethoxy piperidine derivatives
US4179505A (en) * 1977-03-30 1979-12-18 Janssen Pharmaceutica N.V. 5-[4-(Diarylmethyl)-1-piperazinylalkyl]benzimidazole derivatives
JPS5879983A (ja) * 1981-11-06 1983-05-13 Kanebo Ltd 新規なベンズイミダゾ−ル誘導体、その製造法およびその医薬組成物
JPS59199679A (ja) * 1983-04-27 1984-11-12 Kanebo Ltd 新規なベンズイミダゾ−ル誘導体、その製造法およびその医薬組成物
DE3336409A1 (de) * 1983-10-06 1985-04-18 Ludwig Heumann & Co GmbH, 8500 Nürnberg Chinazolinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
US4684654A (en) * 1985-08-14 1987-08-04 American Cyanamid Company 3-heteroalkyl-2,4-quinzaolinediones
CA1317939C (en) * 1987-07-01 1993-05-18 Janssen Pharmaceutica Naamloze Vennootschap ¬(bicyclic heterocyclyl)methyl and -hetero| substituted hexahydro-1h-azepines and pyrrolidines
IT1226100B (it) * 1988-07-07 1990-12-10 Dompe Farmaceutici Spa Derivati benzimidazolici farmacologicamente attivi.
US4902687A (en) * 1989-03-27 1990-02-20 Eli Lilly And Company Excitatory amino acid receptor antagonists
FR2672052B1 (fr) * 1991-01-28 1995-05-24 Esteve Labor Dr Derives d'aryl (ou heteroaryl)-piperazinyl-alkyl-azoles, leur preparation et leur application en tant que medicaments.
FR2673628B1 (fr) * 1991-03-07 1993-07-09 Esteve Labor Dr Procede de preparation de derives d'aryl (ou heteroaryl)-piperazinyl-butyl-azoles.

Also Published As

Publication number Publication date
FR2665161A1 (fr) 1992-01-31
JPH04234387A (ja) 1992-08-24
AU638857B2 (en) 1993-07-08
ES2038074A1 (es) 1993-07-01
HU215109B (hu) 2000-04-28
FR2665161B1 (fr) 1992-11-27
NO178576B (no) 1996-01-15
GR3019352T3 (en) 1996-06-30
CA2047880A1 (fr) 1992-01-27
EP0468884A1 (fr) 1992-01-29
NZ239104A (en) 1993-12-23
NO912669D0 (no) 1991-07-08
ATE131822T1 (de) 1996-01-15
YU48077B (sh) 1997-01-08
CS235191A3 (en) 1992-04-15
TW314518B (es) 1997-09-01
JPH0832703B2 (ja) 1996-03-29
DK0468884T5 (da) 1996-09-30
HU912518D0 (en) 1992-01-28
NO912669L (no) 1992-01-27
RO109736B1 (ro) 1995-05-30
YU123691A (sh) 1994-05-10
CN1058404A (zh) 1992-02-05
RU2024519C1 (ru) 1994-12-15
EP0468884B1 (fr) 1995-12-20
CN1030915C (zh) 1996-02-07
PT98409A (pt) 1992-06-30
ZA915839B (en) 1992-04-29
US5182280A (en) 1993-01-26
KR0183028B1 (ko) 1999-05-01
NO178576C (no) 1996-04-24
PL291247A1 (en) 1992-03-09
MX9100377A (es) 1992-02-28
PL167222B1 (pl) 1995-08-31
HUT58320A (en) 1992-02-28
KR920002587A (ko) 1992-02-28
HU211599A9 (en) 1995-12-28
PT98409B (pt) 1999-01-29
AU8128091A (en) 1992-01-30
DE69115588D1 (de) 1996-02-01
CZ280185B6 (cs) 1995-11-15
DE69115588T2 (de) 1996-06-20

Similar Documents

Publication Publication Date Title
ES2038074B1 (es) Procedimiento para la preparacion de nuevos derivados de benzimidazol.
DE69132497D1 (de) Benzimidazolderivate, verfahren zu deren herstellung und deren anwendung
GR3017643T3 (en) Antihistaminic and non-sedative derivatives of benzimidazol, process for their preparation and their medicinal use.
NO163568C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive kinolonkarboksylsyrederivater.
ATE193705T1 (de) 4-p-fluorbenzoyl-1-piperidinyl-propoxy-chromen- - on derivate, deren herstellung und deren verwendung zur behandlung von psychosen und schizophrenie

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20040601