ES2011210A4 - Derivados de gem-difosfonato subtituido por fenol, proceso para su preparacion y composiciones farmaceuticas conteniendolos - Google Patents

Derivados de gem-difosfonato subtituido por fenol, proceso para su preparacion y composiciones farmaceuticas conteniendolos

Info

Publication number: ES2011210A4
Authority: ES; Spain
Prior art keywords: diphosphonate; gem; phenol; derivatives; substituted
Prior art date: 1988-03-31
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

ES89104656T

Other languages

English (en)

Other versions

ES2011210T3 (es

Inventor

Lan Nguyen

Eric Niesor

Hieu Phan

Pierre Maechler

Craig Bentzen

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Symphar SA

Original Assignee

Symphar SA

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-03-31

Filing date

1989-03-16

Publication date

1990-01-01

1989-03-16 Application filed by Symphar SA filed Critical Symphar SA

1990-01-01 Publication of ES2011210A4 publication Critical patent/ES2011210A4/es

1994-01-01 Application granted granted Critical

1994-01-01 Publication of ES2011210T3 publication Critical patent/ES2011210T3/es

2009-03-16 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3839—Polyphosphonic acids
- C07F9/386—Polyphosphonic acids containing hydroxy substituents in the hydrocarbon radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3839—Polyphosphonic acids
- C07F9/3865—Polyphosphonic acids containing sulfur substituents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4025—Esters of poly(thio)phosphonic acids
- C07F9/404—Esters of poly(thio)phosphonic acids containing hydroxy substituents in the hydrocarbon radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4025—Esters of poly(thio)phosphonic acids
- C07F9/4043—Esters of poly(thio)phosphonic acids containing sulfur substituents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/44—Amides thereof
- C07F9/4403—Amides thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4423—Amides of poly (thio)phosphonic acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C07F9/65515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring
- C07F9/65517—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring condensed with carbocyclic rings or carbocyclic ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
- C07F9/657163—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom
- C07F9/657181—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom the ring phosphorus atom and, at least, one ring oxygen atom being part of a (thio)phosphonic acid derivative

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Obesity (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Hematology (AREA)
General Chemical & Material Sciences (AREA)
Diabetes (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

ES89104656T 1988-03-31 1989-03-16 Derivados de gem-difosfonato substituido, procedimiento para su preparacion y composiciones farmaceuticas que los contienen. Expired - Lifetime ES2011210T3 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CH1239/88A CH675422A5 (es)	1988-03-31	1988-03-31

Publications (2)

Publication Number	Publication Date
ES2011210A4 true ES2011210A4 (es)	1990-01-01
ES2011210T3 ES2011210T3 (es)	1994-01-01

Family

ID=4205733

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ES89104656T Expired - Lifetime ES2011210T3 (es)	1988-03-31	1989-03-16	Derivados de gem-difosfonato substituido, procedimiento para su preparacion y composiciones farmaceuticas que los contienen.

Country Status (25)

Country	Link
US (2)	US5043330A (es)
EP (1)	EP0339237B1 (es)
JP (1)	JPH0822865B2 (es)
KR (1)	KR0147830B1 (es)
CN (2)	CN1024555C (es)
AR (1)	AR247569A1 (es)
AT (1)	ATE84040T1 (es)
AU (1)	AU612475B2 (es)
CA (1)	CA1338495C (es)
CH (1)	CH675422A5 (es)
DE (2)	DE339237T1 (es)
DK (1)	DK173936B1 (es)
ES (1)	ES2011210T3 (es)
FI (1)	FI92933C (es)
GR (2)	GR900300002T1 (es)
HU (1)	HU203556B (es)
IE (1)	IE62692B1 (es)
IL (1)	IL89649A (es)
MY (1)	MY103850A (es)
NO (1)	NO891317L (es)
NZ (1)	NZ228516A (es)
PH (1)	PH27603A (es)
PT (1)	PT90175B (es)
ZA (1)	ZA892126B (es)
ZW (1)	ZW3789A1 (es)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH0377894A (ja) *	1989-08-18	1991-04-03	Toray Ind Inc	メチレンジホスホン酸化合物
JPH05163150A (ja) *	1991-05-13	1993-06-29	E R Squibb & Sons Inc	アテローム性動脈硬化症の抑制・治療剤
US5157027A (en) *	1991-05-13	1992-10-20	E. R. Squibb & Sons, Inc.	Bisphosphonate squalene synthetase inhibitors and method
CA2067974A1 (en) *	1991-05-13	1992-11-14	Scott A. Biller	Method for lowering cholesterol employing a phosphonomethylphosphinate squalene synthetase inhibitor
WO1993005052A1 (fr) *	1991-09-05	1993-03-18	Toray Industries, Inc.	Derive d'acide methanediphosphonique, sa production et son utilisation comme remede
EP0541037A3 (en) *	1991-11-06	1997-02-26	Takeda Chemical Industries Ltd	Squalene synthetase inhibitory composition and use thereof
JPH06172372A (ja) *	1991-11-06	1994-06-21	Takeda Chem Ind Ltd	スクアレン合成酵素阻害剤およびその用途
FR2683529B1 (fr) *	1991-11-12	1994-02-04	Bretagne Occidentale Universite	Composes pharmaceutiques gem-diphosphonates analogues du cis-platine.
CH683996A5 (fr) *	1992-03-05	1994-06-30	Symphar Sa	Dérivés aminophosphonates substitués, leur procédé de préparation et compositions pharmaceutiques les contenant.
CA2111670A1 (en) *	1992-07-10	1994-01-20	Norio Kawabe	A methanediphosphonic acid derivative, process for production thereof and use for pharmaceuticals
US5332728A (en) *	1992-11-23	1994-07-26	Bristol-Myers Squibb Company	Method for treating a fungal infection
US5434288A (en) *	1992-12-01	1995-07-18	Monsanto Company	PLA2 inhibitors
ZA941088B (en) *	1993-02-19	1995-09-27	Symphar Sa	Substituted ketophosphonates the processes for their preparation and pharmaceutical compositions containing them
CN1038033C (zh) *	1993-02-25	1998-04-15	东丽株式会社	甲基二膦酸化合物的制备方法
US5419845A (en) *	1994-03-15	1995-05-30	Basf Corporation	Perfluorinated gemdiphosphonates as corrosion inhibitors for antifreeze coolants and other functional fluids
AU699641B2 (en) *	1994-08-24	1998-12-10	Toray Industries, Inc.	Process for production of methanediphosphonic acid compound
CH690163A5 (fr) *	1995-07-28	2000-05-31	Symphar Sa	Dérivés gem-diphosphonates substitués utiles en tant qu'agents anti-cancers.
GB9603637D0 (en) *	1996-02-21	1996-04-17	Smithkline Beecham Plc	Process
AU2783397A (en) *	1996-05-15	1997-12-05	University Of Sheffield, The	Isopentenyl pyrophosphate isomerase (ipi) and/or prenyl transferase inhibitors
CN100453530C (zh)	1997-05-14	2009-01-21	阿特罗吉尼克斯公司	抑制vcam-1表达的化合物及其药物组合物
US6670398B2 (en) *	1997-05-14	2003-12-30	Atherogenics, Inc.	Compounds and methods for treating transplant rejection
IL125336A0 (en) *	1998-07-14	1999-03-12	Yissum Res Dev Co	Compositions for inhibition and treatment of restinosis
US6984400B2 (en)	1998-07-14	2006-01-10	Yissum Research Development Company Of The Hebrew University Of Jerusalem	Method of treating restenosis using bisphosphonate nanoparticles
US7008645B2 (en)	1998-07-14	2006-03-07	Yissum Research Development Company Of The Hebrew University Of Jerusalem	Method of inhibiting restenosis using bisphosphonates
AUPQ872800A0 (en) *	2000-07-12	2000-08-03	Heart Research Institute, The	Compositions and methods for treating cardiovascular disorders
GB0019272D0 (en) *	2000-08-04	2000-09-27	Symphar Sa	Pharmaceutical compounds
CA2444429A1 (en) *	2001-04-11	2002-11-07	Atherogenics, Inc.	Probucol monoesters and their use to increase plasma hdl cholesterol levels and improve hdl functionality
WO2003032909A2 (en) *	2001-10-18	2003-04-24	Ilex Products, Inc.	Methods of treating skin with diphosphonate derivatives
WO2003070179A2 (en) *	2002-02-19	2003-08-28	Ilex Products, Inc.	Phosphonate-phosphate and diphosphonate apolipoprotein e modulators
AU2003232108A1 (en) *	2002-05-11	2003-11-11	Ilex Products, Inc.	1,1- and 1,2-bisphosphonates as apoliprotein e modulators
WO2004064781A2 (en) *	2003-01-14	2004-08-05	Adam Heller	Anti-inflammatory substituted phenols and elastomeric compositions for oral delivery of drugs
US10517883B2 (en)	2003-06-27	2019-12-31	Zuli Holdings Ltd.	Method of treating acute myocardial infarction
WO2007109585A2 (en) *	2006-03-17	2007-09-27	The Board Of Trustees Of The University Of Illinois	Bisphosphonate compounds and methods
BRPI0809423A2 (pt) *	2007-03-26	2014-09-09	Salutria Pharmaceuticals Llc	Usos e composições de derivados de probucol para o tratamento de diabetes
WO2008118946A1 (en) *	2007-03-27	2008-10-02	Atherogenics, Inc.	Methods and compositions using certain phenolic derivatives for the treatment of diabetes
US9993427B2 (en)	2013-03-14	2018-06-12	Biorest Ltd.	Liposome formulation and manufacture
US10377781B2 (en) *	2014-10-21	2019-08-13	Council Of Scientific & Industrial Research	Alkylidene phosphonate esters as p-glycoprotein inducers
WO2018236221A2 (en) *	2017-06-03	2018-12-27	Can Holding B.V.	DISSOLUTION OF NEURODEGENERATIVE PEPTIDE DEPOSITION

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA777769A (en) *	1963-03-18	1968-02-06	H. Roy Clarence	Substituted methylene diphosphonic acid compounds and detergent compositions
DE1302557B (es) *	1963-04-09	1971-08-26
GB2043072B (en) *	1979-02-13	1983-11-23	Symphar Sa	Diphosphonate compounds
US4416877A (en) *	1979-02-13	1983-11-22	Symphar S.A.	Anti-atherosclerotic pharmaceutical compositions containing diphosphonate compounds
FR2531088B1 (fr) *	1982-07-29	1987-08-28	Sanofi Sa	Produits anti-inflammatoires derives de l'acide methylenediphosphonique et leur procede de preparation
CH664158A5 (fr) *	1984-07-18	1988-02-15	Symphar Sa	Derives propylidenediphosphonates-1,3 substitues en position 2, leur procede de preparation et compositions pharmaceutiques les contenant.
US6259935B1 (en) *	1997-06-24	2001-07-10	Matsushita Electrical Industrial Co., Ltd.	Electro-mechanical-acoustic transducing device

1988
- 1988-03-31 CH CH1239/88A patent/CH675422A5/fr not_active IP Right Cessation
1989
- 1989-03-13 IE IE80289A patent/IE62692B1/en not_active IP Right Cessation
- 1989-03-14 US US07/323,334 patent/US5043330A/en not_active Expired - Lifetime
- 1989-03-15 ZW ZW37/89A patent/ZW3789A1/xx unknown
- 1989-03-16 DE DE198989104656T patent/DE339237T1/de active Pending
- 1989-03-16 MY MYPI89000332A patent/MY103850A/en unknown
- 1989-03-16 EP EP89104656A patent/EP0339237B1/en not_active Expired - Lifetime
- 1989-03-16 DE DE8989104656T patent/DE68904104T2/de not_active Expired - Fee Related
- 1989-03-16 ES ES89104656T patent/ES2011210T3/es not_active Expired - Lifetime
- 1989-03-16 AT AT89104656T patent/ATE84040T1/de not_active IP Right Cessation
- 1989-03-17 IL IL8964989A patent/IL89649A/en not_active IP Right Cessation
- 1989-03-21 ZA ZA892126A patent/ZA892126B/xx unknown
- 1989-03-22 CA CA000594468A patent/CA1338495C/en not_active Expired - Fee Related
- 1989-03-28 DK DK198901481A patent/DK173936B1/da not_active IP Right Cessation
- 1989-03-29 NO NO89891317A patent/NO891317L/no unknown
- 1989-03-29 NZ NZ228516A patent/NZ228516A/en unknown
- 1989-03-29 AR AR89313527A patent/AR247569A1/es active
- 1989-03-30 AU AU32243/89A patent/AU612475B2/en not_active Ceased
- 1989-03-30 CN CN89101830A patent/CN1024555C/zh not_active Expired - Fee Related
- 1989-03-30 HU HU891595A patent/HU203556B/hu not_active IP Right Cessation
- 1989-03-30 FI FI891538A patent/FI92933C/fi not_active IP Right Cessation
- 1989-03-30 PT PT90175A patent/PT90175B/pt not_active IP Right Cessation
- 1989-03-30 KR KR1019890004076A patent/KR0147830B1/ko not_active IP Right Cessation
- 1989-03-30 CN CN93116289A patent/CN1086820A/zh active Pending
- 1989-03-31 PH PH38417A patent/PH27603A/en unknown
- 1989-03-31 JP JP1083855A patent/JPH0822865B2/ja not_active Expired - Fee Related
1991
- 1991-06-07 GR GR90300002T patent/GR900300002T1/el unknown
- 1991-07-31 US US07/738,430 patent/US5128331A/en not_active Expired - Lifetime
1993
- 1993-03-23 GR GR930400629T patent/GR3007442T3/el unknown

Also Published As

Publication number	Publication date
IE62692B1 (en)	1995-02-22
JPH0222285A (ja)	1990-01-25
GR3007442T3 (es)	1993-07-30
AU3224389A (en)	1989-10-05
NO891317L (no)	1989-10-02
DE68904104T2 (de)	1993-06-17
PT90175A (pt)	1989-11-10
IE890802L (en)	1989-09-30
US5128331A (en)	1992-07-07
FI891538A0 (fi)	1989-03-30
CN1036772A (zh)	1989-11-01
ES2011210T3 (es)	1994-01-01
IL89649A0 (en)	1989-09-28
ATE84040T1 (de)	1993-01-15
DK148189A (da)	1989-10-17
IL89649A (en)	1995-07-31
AR247569A1 (es)	1995-01-31
EP0339237A3 (en)	1991-01-09
EP0339237A2 (en)	1989-11-02
MY103850A (en)	1993-09-30
CN1024555C (zh)	1994-05-18
KR0147830B1 (ko)	1998-08-17
PT90175B (pt)	1994-06-30
PH27603A (en)	1993-08-31
US5043330A (en)	1991-08-27
FI891538A (fi)	1989-10-01
DK173936B1 (da)	2002-02-25
DE68904104D1 (de)	1993-02-11
ZA892126B (en)	1989-11-29
HUT50482A (en)	1990-02-28
HU203556B (en)	1991-08-28
CA1338495C (en)	1996-07-30
CN1086820A (zh)	1994-05-18
CH675422A5 (es)	1990-09-28
EP0339237B1 (en)	1992-12-30
AU612475B2 (en)	1991-07-11
KR890014569A (ko)	1989-10-24
JPH0822865B2 (ja)	1996-03-06
DK148189D0 (da)	1989-03-28
ZW3789A1 (en)	1989-08-23
NO891317D0 (no)	1989-03-29
FI92933C (fi)	1995-01-25
DE339237T1 (de)	1990-02-08
GR900300002T1 (en)	1991-06-07
NZ228516A (en)	1990-12-21
FI92933B (fi)	1994-10-14

Publication	Publication Date	Title
ES2011210A4 (es)	1990-01-01	Derivados de gem-difosfonato subtituido por fenol, proceso para su preparacion y composiciones farmaceuticas conteniendolos
PT91731A (pt)	1990-03-30	Processo para a preparacao de composicoes farmaceuticas contendo ciclosporinas
PT87958A (pt)	1989-06-30	Processo para a preparacao de composicoes farmaceuticas, contendo antagonistas 5ht-3
BR9100435A (pt)	1991-10-22	Composto,composicao farmaceutica,uso,metodo de tratamento de um animal,processos para a preparacao da um composto e de uma composicao farmaceutica
MX10621A (es)	1993-09-01	Compuestos de piperazinil heterociclicos y procedimiento para su preparacion.
MX9206236A (es)	1993-04-01	Composiciones farmaceuticas de liberacion controlada y proceso para su preparacion.
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