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ES2002207A6 - Un metodo para producir derivados de glucosilmoranolina - Google Patents

Un metodo para producir derivados de glucosilmoranolina

Info

Publication number
ES2002207A6
ES2002207A6 ES8602549A ES8602549A ES2002207A6 ES 2002207 A6 ES2002207 A6 ES 2002207A6 ES 8602549 A ES8602549 A ES 8602549A ES 8602549 A ES8602549 A ES 8602549A ES 2002207 A6 ES2002207 A6 ES 2002207A6
Authority
ES
Spain
Prior art keywords
blood sugar
sugar levels
inhibiting increase
glucosylmoranoline
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8602549A
Other languages
English (en)
Inventor
Makoto Sugiyama
Yoji Ezure
Yoshiaki Yoshikuni
Takayuki Ozaki
Nobutoshi Ojima
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Shinyaku Co Ltd
Original Assignee
Nippon Shinyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP11161886A external-priority patent/JPS62267291A/ja
Application filed by Nippon Shinyaku Co Ltd filed Critical Nippon Shinyaku Co Ltd
Publication of ES2002207A6 publication Critical patent/ES2002207A6/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

UN METODO PARA PRODUCIR DERIVADOS DE GLUCOSILMORANOLINA, EN EL QUE SE HIDROXIALQUILA 4-0-AL-FA-D-GLUCOPIRANOSILMORANOLINA O SE CONVIERTE N-(HIDROXIALQUIL)-MORANOLINA (O UN DERIVADO DE ESTA) EN UN COMPUESTO OLIGOGLUCOSILICO, EL CUAL SE TRATA SEGUIDAMENTE CON GLUCOAMILASA. LOS COMPUESTOS OBTENIDOS PRESENTAN ACTIVIDAD REDUCTORA DEL NIVEL DE AZUCAR EN LA SANGRE. LA PRESENTE INVENCION SE REFIERE A LA OBTENCION DE UN COMPUESTO REPRESENTADO POR LA SIGUIENTE FORMULA GENERAL I QUE MUESTRA ACCION INHIBIDORA CONTRA EL AUMENTO DEL AZUCAR EN SANGRE: EN LA QUE R ES UN GRUPO ALQUILO QUE TIENE UNO OMAS GRUPOS HIDROXILO. TECNICA ANTERIOR LA MORALINA ESTA REPRESENTADA POR LA SIGUIENTE ESTRUCTURA QUIMICA Y ES MUY UTIL COMO COMPUESTO FARMACEUTICO QUE TIENE UN EFECTO TERAPEUTICO PARA LA DIABETES MELLITUS:
ES8602549A 1985-10-12 1986-10-10 Un metodo para producir derivados de glucosilmoranolina Expired ES2002207A6 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP22760185 1985-10-12
JP11161886A JPS62267291A (ja) 1986-05-14 1986-05-14 モラノリン誘導体の製法

Publications (1)

Publication Number Publication Date
ES2002207A6 true ES2002207A6 (es) 1988-07-16

Family

ID=26450971

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8602549A Expired ES2002207A6 (es) 1985-10-12 1986-10-10 Un metodo para producir derivados de glucosilmoranolina

Country Status (6)

Country Link
US (1) US4859767A (es)
DE (1) DE3634496C2 (es)
ES (1) ES2002207A6 (es)
FR (1) FR2591600B1 (es)
GB (1) GB2181729B (es)
IT (1) IT1214726B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2504000B2 (ja) * 1986-09-02 1996-06-05 日本新薬株式会社 グルコシルモラノリン誘導体
EP0345104B1 (en) * 1988-06-02 1995-11-02 Merrell Dow Pharmaceuticals Inc. Novel Alpha-glucosidase inhibitors
EP0344383A1 (en) * 1988-06-02 1989-12-06 Merrell Dow Pharmaceuticals Inc. Novel alpha-Glucosidase inhibitors
US5504078A (en) * 1990-06-08 1996-04-02 Merrell Dow Pharmaceuticals Inc. α-glucosidase inhibitors
ATE130304T1 (de) * 1990-06-08 1995-12-15 Merrell Dow Pharma Neue alpha-glukosidaseinhibitoren.
EP0627442A4 (en) * 1992-01-31 1995-01-11 Nippon Shinyaku Co Ltd DERIVATIVE OF A LEWIS TYPE SUGAR CHAIN.
KR101897765B1 (ko) 2017-06-20 2018-09-12 한림대학교 산학협력단 신규의 1-데옥시노지리마이신 유도체 및 이의 혈당강하제로서의 용도

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5283951A (en) * 1976-01-01 1977-07-13 Nippon Shinyaku Co Ltd Remedy for hyperglycemia and depressant for lipid-biosythesis
JPS5484094A (en) * 1977-11-21 1979-07-04 Nippon Shinyaku Co Ltd Preparation of piperidine derivative
JPS54106477A (en) * 1978-02-03 1979-08-21 Nippon Shinyaku Co Ltd Moranoline derivative
GB2064527B (en) * 1979-12-08 1984-05-02 Nippon Shinyaku Co Ltd Moranoline derivatives and process for preparation thereof
JPS56108768A (en) * 1980-01-28 1981-08-28 Nippon Shinyaku Co Ltd Cinnamylmoranoline derivative
JPS56108767A (en) * 1980-01-28 1981-08-28 Nippon Shinyaku Co Ltd Bismoranoline derivative
DE3024901A1 (de) * 1980-07-01 1982-01-28 Bayer Ag, 5090 Leverkusen Herbizide mittel auf basis von piperidin-derivaten
JPS6055078B2 (ja) * 1980-12-01 1985-12-03 日本新薬株式会社 モラノリンの誘導体
JPS6024798A (ja) * 1983-07-20 1985-02-07 Matsushita Electric Ind Co Ltd リモ−トコントロ−ル装置
US4634765A (en) * 1984-12-18 1987-01-06 Merrell Dow Pharmaceuticals Inc. Homodisaccharide hypoglycemic agents

Also Published As

Publication number Publication date
GB2181729A (en) 1987-04-29
IT1214726B (it) 1990-01-18
GB2181729B (en) 1990-04-04
US4859767A (en) 1989-08-22
FR2591600B1 (fr) 1990-05-11
DE3634496A1 (de) 1987-04-16
FR2591600A1 (fr) 1987-06-19
GB8623513D0 (en) 1986-11-05
IT8648535A0 (it) 1986-10-10
DE3634496C2 (de) 1996-11-14

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20010301