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ES2002161A6 - Procedimiento para preparar 1,3-diazabiciclo (4.4.0)dec-2-en-4-onas antiarritmicas - Google Patents

Procedimiento para preparar 1,3-diazabiciclo (4.4.0)dec-2-en-4-onas antiarritmicas

Info

Publication number
ES2002161A6
ES2002161A6 ES8601961A ES8601961A ES2002161A6 ES 2002161 A6 ES2002161 A6 ES 2002161A6 ES 8601961 A ES8601961 A ES 8601961A ES 8601961 A ES8601961 A ES 8601961A ES 2002161 A6 ES2002161 A6 ES 2002161A6
Authority
ES
Spain
Prior art keywords
diazabicyclo
dec
ones
antiarrhytmic
intermediates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8601961A
Other languages
English (en)
Inventor
Laughlin Kathleen Theres Mc
Robert John Chorvat
Kathleen Ann Prodan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GD Searle LLC
Original Assignee
GD Searle LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GD Searle LLC filed Critical GD Searle LLC
Publication of ES2002161A6 publication Critical patent/ES2002161A6/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR 1,3-DIAZABICICLO 4.4.0 DEC-2-EN-4-ONAS ANTIRRITMICAS, DE FORMULA (II) EN DONDE, NOEXCLUSIVAMENTE, R ES HIDROGENO, ALQUILO 1-6 C O FENILO. SE OBTIENEN POR ACILACION DE UN COMPUESTO DE FORMULA (III) Y CICLACION DEL COMPUESTO RESULTANTE DE FORMULA (I).
ES8601961A 1985-09-19 1986-09-17 Procedimiento para preparar 1,3-diazabiciclo (4.4.0)dec-2-en-4-onas antiarritmicas Expired ES2002161A6 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/777,661 US4791199A (en) 1985-09-19 1985-09-19 Process for antiarrhythmic 1,3-diazabicyclo[4.4.0]dec-2-en-4-ones

Publications (1)

Publication Number Publication Date
ES2002161A6 true ES2002161A6 (es) 1988-07-16

Family

ID=25110892

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8601961A Expired ES2002161A6 (es) 1985-09-19 1986-09-17 Procedimiento para preparar 1,3-diazabiciclo (4.4.0)dec-2-en-4-onas antiarritmicas

Country Status (6)

Country Link
US (1) US4791199A (es)
EP (1) EP0215477A1 (es)
JP (1) JPS6270375A (es)
AU (1) AU589447B2 (es)
ES (1) ES2002161A6 (es)
ZA (1) ZA867114B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5061772A (en) * 1987-05-07 1991-10-29 The B. F. Goodrich Company Process for making comb-shaped copolymers of a macromolecular monomer of polylactone with terminal acryloyl unsaturation, and compatible blends thereof
JP7050899B2 (ja) * 2017-08-29 2022-04-08 ダウ グローバル テクノロジーズ エルエルシー トリーイング遅延剤を含むポリエチレン組成物

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4217306A (en) * 1978-05-01 1980-08-12 G. D. Searle & Co. α-Aryl-α,α-bis[ω-(disubstituted amino)alkyl]-acetamides
AU574652B2 (en) * 1982-09-27 1988-07-14 G.D. Searle & Co. Pyridopyrimidones
US4560754A (en) * 1983-09-14 1985-12-24 G. D. Searle & Co. Substituted 5-phenyl-5-(aminoalkyl)-1,3-diazabicyclo[4.4.0]decan-4-ones and 5-phenyl-5-(aminoalkyl)-1,3-diazabicyclo[4.4.0]dec-2-en-4-ones
DE3344429A1 (de) * 1983-12-08 1985-06-20 Wacker-Chemie GmbH, 8000 München Verfahren zur herstellung von 2-isopropyl-4-methyl-6-hydroxypyrimidin
IL76583A (en) * 1984-10-19 1988-08-31 Robins Co Inc A H 1-(aminoalkyl)-alpha'alpha-diaryl pyrrolidinyl,piperidino and homopiperidino acetamides and acetonitriles and pharmaceutical compositions containing them
US4680295A (en) * 1986-02-03 1987-07-14 G. D. Searle & Co. Octahydropyrido[1,2-c]pyrimidinones and hexahydropyrido[1,2-c]pyrimidinediones

Also Published As

Publication number Publication date
JPS6270375A (ja) 1987-03-31
AU6277086A (en) 1987-03-26
US4791199A (en) 1988-12-13
AU589447B2 (en) 1989-10-12
ZA867114B (en) 1987-11-25
EP0215477A1 (en) 1987-03-25

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20001102