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ES2000739A6 - Un procedimiento para preparar derivados de acido quinoleino-carboxilico - Google Patents

Un procedimiento para preparar derivados de acido quinoleino-carboxilico

Info

Publication number
ES2000739A6
ES2000739A6 ES8600554A ES8600554A ES2000739A6 ES 2000739 A6 ES2000739 A6 ES 2000739A6 ES 8600554 A ES8600554 A ES 8600554A ES 8600554 A ES8600554 A ES 8600554A ES 2000739 A6 ES2000739 A6 ES 2000739A6
Authority
ES
Spain
Prior art keywords
substituted
esterified
medicaments
dihydroxy
quinoline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8600554A
Other languages
English (en)
Inventor
Francois Clemence
Martret Odile Le
Francoise Delevallee
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Publication of ES2000739A6 publication Critical patent/ES2000739A6/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/20—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 4
    • C07D265/22—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Saccharide Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

SE DESCRIBE UN PROCEDIMIENTO DE PREPARACION DE NUEVOS DERIVADOS DEL ACIDO QUINOLEINO-CARBOXILICO DE FORMULA (I) Y SUS SALES: EN LA CUAL X EN LA POSICION 5, 6, 7 U 8 ES H, HALOGENO, ALQUILO O ALCOXI, -CF3, SCF3 O -OCF3, R1 ES UN HETEROCICLO SUSTITUIDO EVENTUALMENTE POR UN ALQUILO O UN FENILO EVENTUALMENTE SUSTITUIDO, R2 Y R3, IDENTICOS O DIFERENTES, SON H, ALQUILO, ARILO -C-R5, DONDE R5 ES ALQUILO O ARILO, O R2 Y R3 FORMAN UN ACETONICO, Y R4 ES H, ALQUILO O ARILO. LOS COMPUESTOS DE FORMULA (I) SON UTILES COMO MEDICAMENTOS, PRINCIPALMENTE ANALGESICOS Y ANTI-INFLAMATORIOS.
ES8600554A 1985-07-25 1986-07-24 Un procedimiento para preparar derivados de acido quinoleino-carboxilico Expired ES2000739A6 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8511389A FR2585356B1 (fr) 1985-07-25 1985-07-25 Nouveaux derives de l'acide 4-oh quinoleine carboxylique substitues en 2 par deux fonctions hydroxyle eventuellement etherifiees ou esterifiees, leurs procedes de preparation, les nouveaux intermediaires obtenus, leur application comme medicaments et les compositions les renfermant

Publications (1)

Publication Number Publication Date
ES2000739A6 true ES2000739A6 (es) 1988-03-16

Family

ID=9321642

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8600554A Expired ES2000739A6 (es) 1985-07-25 1986-07-24 Un procedimiento para preparar derivados de acido quinoleino-carboxilico

Country Status (16)

Country Link
EP (1) EP0214004B1 (es)
JP (1) JPH0710863B2 (es)
KR (1) KR940003759B1 (es)
AT (1) ATE87625T1 (es)
AU (1) AU609377B2 (es)
CA (1) CA1262903A (es)
DE (1) DE3688161T2 (es)
DK (1) DK172034B1 (es)
ES (1) ES2000739A6 (es)
FI (1) FI86426C (es)
FR (1) FR2585356B1 (es)
GR (1) GR861924B (es)
HU (1) HU202526B (es)
PT (1) PT83064B (es)
SU (1) SU1584749A3 (es)
ZA (1) ZA865260B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4845105A (en) * 1984-10-30 1989-07-04 Roussel Uclaf 4-OH-quinoline carboxylic acid amides having analgesic and anti-inflammatory activity
US5438344A (en) * 1990-11-05 1995-08-01 Oliva; Anthony Portable video book
GB9108547D0 (en) * 1991-04-22 1991-06-05 Fujisawa Pharmaceutical Co Quinoline derivatives
AU3339797A (en) * 1996-06-20 1998-01-07 Smithkline Beecham Plc 4h-3,1-benzoxazin-4-one derivatives and analogs as antiviral agents
JP3337992B2 (ja) * 1997-11-04 2002-10-28 ファイザー製薬株式会社 ５−置換ピコリン酸化合物及びその製造方法
JP4804590B1 (ja) 2010-04-14 2011-11-02 帝人テクノプロダクツ株式会社 メタ型全芳香族ポリアミド繊維

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS593996B2 (ja) * 1975-11-25 1984-01-27 キツセイ薬品工業株式会社 ２−スチリル−３，１−ベンゾオキサジン−４−オン誘導体及びその製造方法
JPS593995B2 (ja) * 1975-12-31 1984-01-27 キツセイヤクヒンコウギヨウ カブシキガイシヤ ２− スチリル −３，１− ベンゾオキサジン −４− オンユウドウタイノセイゾウホウホウ
FR2509728A1 (fr) * 1981-07-17 1983-01-21 Roussel Uclaf Nouveaux derives de la quinoleine, leurs sels, procede de preparation, application a titre de medicaments et compositions les renfermant
FR2530633A1 (fr) * 1982-06-03 1984-01-27 Roussel Uclaf Nouveaux derives de l'acide 4-hydroxy 3-quinoleine carboxylique substitues en 2, leur preparation, leur application comme medicament, et les compositions les renfermant
FR2566405B1 (fr) * 1984-06-25 1986-09-26 Roussel Uclaf Nouveaux derives de l'acide 4-hydroxy 3-quinoleine carboxylique substitues en 2 par une fonction aminee, leur preparation, leur application comme medicaments, les compositions les renfermant et les intermediaires nouveaux obtenus
ZA871658B (en) * 1986-03-27 1987-08-28 Warner-Lambert Company Chewing gum and confectionery compositions containing a soy flavor enhancer

Also Published As

Publication number Publication date
FR2585356A1 (fr) 1987-01-30
DK172034B1 (da) 1997-09-22
KR940003759B1 (ko) 1994-04-30
PT83064A (en) 1986-08-01
JPS6229585A (ja) 1987-02-07
PT83064B (pt) 1989-02-28
DK351886D0 (da) 1986-07-24
JPH0710863B2 (ja) 1995-02-08
EP0214004A2 (fr) 1987-03-11
DE3688161D1 (de) 1993-05-06
ATE87625T1 (de) 1993-04-15
HU202526B (en) 1991-03-28
SU1584749A3 (ru) 1990-08-07
DK351886A (da) 1987-01-26
FR2585356B1 (fr) 1987-10-23
GR861924B (en) 1986-11-25
CA1262903A (fr) 1989-11-14
KR870001206A (ko) 1987-03-12
FI86426B (fi) 1992-05-15
HUT43598A (en) 1987-11-30
FI863040A0 (fi) 1986-07-24
FI863040A (fi) 1987-01-26
EP0214004A3 (en) 1989-04-05
ZA865260B (en) 1987-09-30
AU6050986A (en) 1987-01-29
FI86426C (fi) 1992-08-25
EP0214004B1 (fr) 1993-03-31
DE3688161T2 (de) 1993-10-14
AU609377B2 (en) 1991-05-02

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