[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

ES2099879T3 - 5-oxo-dibenzo(a,d)ciclohepta-1,4-dienos y su uso como agentes retrovirales. - Google Patents

5-oxo-dibenzo(a,d)ciclohepta-1,4-dienos y su uso como agentes retrovirales.

Info

Publication number
ES2099879T3
ES2099879T3 ES93114676T ES93114676T ES2099879T3 ES 2099879 T3 ES2099879 T3 ES 2099879T3 ES 93114676 T ES93114676 T ES 93114676T ES 93114676 T ES93114676 T ES 93114676T ES 2099879 T3 ES2099879 T3 ES 2099879T3
Authority
ES
Spain
Prior art keywords
dienos
ciclohepta
dibenzo
oxo
retroviral agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93114676T
Other languages
English (en)
Inventor
Hanno Dr Wild
Jutta Dr Hansen
Jorg Dr Lautz
Arnold Dr Paessens
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Application granted granted Critical
Publication of ES2099879T3 publication Critical patent/ES2099879T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/20—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by nitrogen atoms not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4056—Esters of arylalkanephosphonic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/30—Ortho- or ortho- and peri-condensed systems containing three rings containing seven-membered rings
    • C07C2603/32—Dibenzocycloheptenes; Hydrogenated dibenzocycloheptenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Polarising Elements (AREA)
  • Peptides Or Proteins (AREA)
  • Quinoline Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

LA INVENCION SE REFIERE A 5-OXO-DIBENZO [A, D]-CICLOHEPTA-1, 4DIENO DE FORMULA (I) CON LOS SUBSTITUYENTES INDICADOS EN LA DESCRIPCION. PROCEDIMIENTO PARA SU PRODUCCION Y SU APLICACION COMO MEDIOS RETROVIRALES.
ES93114676T 1992-09-25 1993-09-13 5-oxo-dibenzo(a,d)ciclohepta-1,4-dienos y su uso como agentes retrovirales. Expired - Lifetime ES2099879T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4232173A DE4232173A1 (de) 1992-09-25 1992-09-25 5-Oxo-dibenzo(a,d)cyclohepta-1,4-diene

Publications (1)

Publication Number Publication Date
ES2099879T3 true ES2099879T3 (es) 1997-06-01

Family

ID=6468847

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93114676T Expired - Lifetime ES2099879T3 (es) 1992-09-25 1993-09-13 5-oxo-dibenzo(a,d)ciclohepta-1,4-dienos y su uso como agentes retrovirales.

Country Status (18)

Country Link
US (1) US5457108A (es)
EP (1) EP0589322B1 (es)
JP (1) JPH06239827A (es)
KR (1) KR940006996A (es)
CN (1) CN1086809A (es)
AT (1) ATE150450T1 (es)
AU (1) AU659337B2 (es)
CA (1) CA2106892A1 (es)
DE (2) DE4232173A1 (es)
DK (1) DK0589322T3 (es)
ES (1) ES2099879T3 (es)
GR (1) GR3023196T3 (es)
HU (2) HUT65291A (es)
IL (1) IL107068A (es)
MX (1) MX9305773A (es)
NZ (1) NZ248737A (es)
TW (1) TW278071B (es)
ZA (1) ZA937077B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE37781E1 (en) 1991-10-11 2002-07-02 Dupont Pharmaceuticals Company Substituted cyclic carbonyls and derivatives thereof useful as retroviral protease inhibitors
US6071895A (en) 1992-03-11 2000-06-06 Narhex Limited Polar-substituted hydrocarbons
JPH07504654A (ja) 1992-03-11 1995-05-25 ナルヘックス　リミテッド オキソ及びヒドロキシ置換炭化水素のアミン誘導体
US5888992A (en) 1992-03-11 1999-03-30 Narhex Limited Polar substituted hydrocarbons
DE69333270T2 (de) 1992-03-11 2004-08-05 Narhex Ltd. Aminderivate von oxo- und hydroxy- substituierten kohlenwasserstoffen
IL110898A0 (en) * 1993-09-10 1994-11-28 Narhex Australia Pty Ltd Polar-substituted hydrocarbons
US5705524A (en) * 1994-11-04 1998-01-06 Gilead Sciences, Inc. Thiepane compounds
US6034118A (en) * 1994-11-04 2000-03-07 Gilead Sciences, Inc. Thiepane compounds
US6169911B1 (en) 1997-09-26 2001-01-02 Sun Microsystems, Inc. Graphical user interface for a portable telephone
US6313110B1 (en) 1999-06-02 2001-11-06 Dupont Pharmaceuticals Company Substituted 2H-1,3-diazapin-2-one useful as an HIV protease inhibitor
DE10238818A1 (de) 2002-08-23 2004-03-04 Wacker-Chemie Gmbh Cyclodextrinreste aufweisende Organosiliciumverbindungen
WO2015188309A1 (zh) * 2014-06-10 2015-12-17 华东理工大学 6,7,8,9-四氢-5h-苯并[7]轮烯-2-烷基胺类化合物及其用途

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3401192A (en) * 1962-07-17 1968-09-10 Merck & Co Inc Esters of 5h-dibenzo [a, d] cycloheptene
US3264342A (en) * 1963-05-24 1966-08-02 Geigy Chem Corp Derivatives of 5h-dibenzo[a, d] cycloheptene
US3390179A (en) * 1963-07-22 1968-06-25 Merck & Co Inc Novel 10, 11-dihydro-10, 11-dihydroxy-(3-substituted aminopropylidene)-5h-dibenzo [a, d] cycloheptenes
US3403157A (en) * 1965-09-01 1968-09-24 American Home Prod Benzo[6, 7]cyclohepta[1, 2, 3-d, e]isoquinoline derivatives
US3436402A (en) * 1966-03-11 1969-04-01 Lilly Co Eli 1,1 diaryl-2-propynyl carbamates
US3513201A (en) * 1966-10-25 1970-05-19 Merck & Co Inc Process for preparing 5-(3-alkylaminopropyl)-5h-dibenzo(a,d)cycloheptenes
US3911017A (en) * 1969-04-04 1975-10-07 Sandoz Ag 5-Aminomethyl-5H-dibenzo{8 a,d{9 cycloheptenes
US3992445A (en) * 1972-08-25 1976-11-16 Merck & Co., Inc. 5-Formamidomethyl-5H-dibenzo[a,d]cycloheptene derivatives
US4062840A (en) * 1973-05-02 1977-12-13 Akzona Incorporated Amino-substituted 1,2,3,4-tetrahydro-9H-tribenzo[b,d,f]azepines
US3994961A (en) * 1973-07-30 1976-11-30 Sandoz, Inc. 10-(2-Substituted-amino-ethyl)-10,11-dihydro-5-methylene-5H-debenzo[a,d]cycloheptenes
US4317910A (en) * 1978-03-20 1982-03-02 E. R. Squibb & Sons, Inc. Benzo-cyclitolamines
US4596892A (en) * 1982-08-19 1986-06-24 Fmc Corporation Methanamine intermediates to insecticidal 2,2'-bridged [1,1'-biphenyl]-3-ylmethyl carboxamides

Also Published As

Publication number Publication date
TW278071B (es) 1996-06-11
KR940006996A (ko) 1994-04-26
HUT65291A (en) 1994-05-02
CN1086809A (zh) 1994-05-18
HU211175A9 (en) 1995-11-28
DK0589322T3 (da) 1997-09-22
AU4493093A (en) 1994-03-31
AU659337B2 (en) 1995-05-11
HU9302706D0 (en) 1993-12-28
CA2106892A1 (en) 1994-03-26
ZA937077B (en) 1994-04-18
EP0589322A1 (de) 1994-03-30
MX9305773A (es) 1994-05-31
US5457108A (en) 1995-10-10
GR3023196T3 (en) 1997-07-30
IL107068A (en) 1997-07-13
DE4232173A1 (de) 1994-03-31
DE59305855D1 (de) 1997-04-24
IL107068A0 (en) 1993-12-28
ATE150450T1 (de) 1997-04-15
EP0589322B1 (de) 1997-03-19
NZ248737A (en) 1995-07-26
JPH06239827A (ja) 1994-08-30

Similar Documents

Publication Publication Date Title
ES2056071T3 (es) Triazolinonas substituidas.
ES2097174T3 (es) Derivados de la 2-ciclohexan-1-il amina.
DE69021501D1 (de) Anti-entzündende 4-aminophenol-derivate.
MX9201760A (es) Quinoxalinas, procedimiento para su preparacion y su empleo.
ES2093860T3 (es) Nuevos derivados de arilcicloalquilo, su produccion y su uso.
ES2099879T3 (es) 5-oxo-dibenzo(a,d)ciclohepta-1,4-dienos y su uso como agentes retrovirales.
DE59100670D1 (de) Bausatz zur herstellung von büro-arbeitstischen.
ES2179864T3 (es) 4-benzoil-isoxazoles y su uso como herbicidas.
ATE46518T1 (de) Sialosylcerebroside und verfahren zu ihrer herstellung.
ES2003063A4 (es) Derivados de pirrolidin-2-ona, que tengan actividad nootropica.
ES2061550T3 (es) Vinilcefalosporinas substituidas, procedimiento para su preparacion y su uso como medicamento.
ES8605247A1 (es) Procedimiento para la obtencion de arisulfonilguanidinas sustituidas
ES8708132A1 (es) Procedimiento para preparar n-fenil-4-fenil-1-piperazincarboxamidinas y compuestos afines como agentes anti-arritmicos
AR021616A1 (es) Cicloheptenos sustituidos, procedimiento para su preparacion y uso de los mismos.
ES8703847A1 (es) Procedimiento para la obtencion de derivados de sulfonilgua-nidinopirimidina
ES2063562T3 (es) Uso de 5,6-dihidro-dibenz(b,e)acepina-6,11-dion-11-oximas en la elaboracion de sustancias antirretrovirales.
ES2004215A6 (es) Procedimiento para preparar quinazolinas tetraciclicas
ES8703855A1 (es) Procedimiento para la obtencion de derivados de sulfonilgua-nidinotriazina
FI960588A0 (fi) Mikrobisideina käytettäviä tiokarbamoyyliyhdisteitä
ES2063561T3 (es) 6-tiono-5,6-dihidro-dibenz(b,e)azepin-11-on-11-oximas y su uso como agentes retrovirales.
ATE60326T1 (de) Neue pharmakologisch wirksame phenoxazinone, verfahren zu ihrer herstellung und ihre verwendung.
ES2036577T3 (es) Procedimiento de preparacion de bencensulfonamidas utiles como agentes anti-arritmicos.
SU1037648A1 (ru) 3-Фенилвинил-5,6,7,8-тетрагидро-6,8-диметилпиримидо-[5,4-е] [1,2,4]-триазин-5, 7-дион, проявляющий противовоспалительную активность
SU1162191A1 (ru) 1,1-Этилиденди-(5-бром-2-фуроиламин), проявляющий противовоспалительную активность
AR241135A2 (es) "derivados de n-triazinil-n-sulfamoilurea herbicidamente activos y formulacion herbicida que los contiene".

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 589322

Country of ref document: ES